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Control of thyroid functionby a negative-feedback loop:The hypothalamus releases TRHTRH acts on the pituitary gland to release TSHTSH acts on the thyroid gland to release the thyroid hormones (T3 and T4) that regulate metabolismTRH and TSH concentrations are inversely related to T3 and T4 concentrations. 99% circulating T3 and T4 is bound to TBG. 1% circulate in the free form, and only the free forms are biologically active..

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