Cholinergic Receptors Antagonists. 59-291 Section 2, lecture 3. Muscarinic Receptor Antagonists Belladonna alkaloids Derived from plants; Atropa belladonna (the deadly night shade) Atropine, scopolamine Well absorbed from the gut and distributed to CNS
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59-291 Section 2, lecture 3
Pharmacologic effects- muscarinic receptor antagonists inhibit parasympathetic nerve stimulation
These effects are dose dependent
Contract vascular smooth muscle, iris, bladder sphincter muscle
Inhibits NE release