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  1. Training Passende Bildauswahl! Essential nutrients for your health

  2. Whatis a Food Supplement?

  3. Content • Key Message • Introduction • Product Information • Key Benefits • Target Group • Ingredients • Posology & Administration • Osmoregulation • Dehydration • Diarrhea • Good to Know • Complementary Treatment • References

  4. 1. Key Message • Duringphysicalactivity, the body loses waterbysweating. • Also otherconditions, like increasedbodytemperatureorwaterystool, areassociatedwithincreasedwaterloss. • The rightamountofelectrolytesisable to support the regenerationof the body after physicaleffortand to restoreitswaterbalance. contains electrolytes with its composition according to WHO recommendations for • fast replenishment of electrolytes and water • balanced water balance in the body

  5. 2. Introduction • By body weight, the average human adult male is approximately 60 % and the average adult female is approximately50-55 % water. 1 • Most of the organs and tissues contain more than 70 % water, whereas adipose tissue contains only 10 % of water. 1 • Water is the most important element of the body. It is required for: 1 • Transportation and solution of nutrients • Removal and excretion of degradation products • Regulation of body temperature • Osmoregulation of body cells Total body water 60 % of body weight(70 kg -> 42 L)

  6. 3. Product Information Electrolyte-glucose mixture to support water balance

  7. 3. Product Information Electrolyte-glucose mixture to support water balance

  8. 4. Key Benefits • electrolyte Denk is an oral solution with its composition according to WHO recommendations. 2 • electrolyte Denk is hypotonic - for the most rapid rehydration. • Important elctrolytes, glucose and zinc for fast replenishment of physical reserves and to support water balance. • Practical hygienic formulation packs of 200 ml – ideal for on the way or during holidays. • Lemon grapefruit taste for the easy intake.

  9. 5. Target Group Excessive sweating 3→You lose water when you sweat. If you do vigorous activity and don't replace fluids as you go along, you can become dehydrated. Diarrhea, vomiting (adults & children) 3 → severe, acute diarrhea can cause a tremendous loss of water and electrolytes in a short amount of time. Fever 3→In general, the higher your fever, the more dehydrated you may become. If you have a fever in addition to diarrhea and vomiting, you lose even more fluids.

  10. 6. Ingredients INGREDIENTS ishypotonic(251 mOsm/L)in order to allowthe most rapid rehydration!

  11. 6. Ingredients Glucose Glucose facilitates the absorption of sodium (and hence water) in the small intestine.4 Sodium The body needs sodium chloride for the function of nerves and muscles. It also helps to keep the right balance of fluids in the body. 2 Potassium Potassium is important for muscle contraction, cardiovascular function and use in the nervous and digestive system. 2, 5 Chloride Chloride is needed to keep the proper balance of body fluids. Too little chloride in the body can occur when the body loses a lot of fluids. 6 Zinc Zinc is essential for protein synthesis, cell growth, immune function and intestinal transport of water and electrolytes. 7

  12. 7. Posology & Administration Recommended Intake • Dissolve and stir the content of one stick in 200 ml of drinking water. • Boiled water can be used after cooling if drinking water is not available. • Prepare the solution immediately before use. • Infants and toddlers should not receive more than 5 sticks electrolyte Denk per day. How to give electrolyte Denk for children? • The solution should be given to infants and youngchildren using a clean spoon or cup. • Feeding bottles should not be used. • A doctor should be consulted if vomiting, fever,or diarrhea continues beyond 24 hours orif consumption needs are greater than 1 liter per day.

  13. 8. Osmoregulation What is osmoregulation? 1 • Osmoregulation is a complex process that refers to the control of the water and mineral salt content of the body. • It is defined as the process by which cells maintain fluid and electrolyte balance with their surrounding. • The body fluids have – with few exceptions – an osmolarity of ca. 290 mOsm/kg H₂O, where intra- and extracellular space are usually at equilibrium.

  14. 8. Osmoregulation Solutions can be hypotonic, isotonic and hypertonic: 1 (diluted) Hypotonic solutions are necessary to reverse dehydration HYPOTONIC

  15. 8. Osmoregulation Electrolytes influence the flow direction of body fluids:1, 8, 9 • Electrolytes are salts and minerals that can conduct electrical impulses in the body. • Common electrolytes include: Potassium, phosphorus, calcium, sodium, magnesium and chloride. Electrolytes affect the body functions in many ways, including: • The amount of water in the body • The acidity in the blood (pH) • Muscle contraction • Energy generation • Biochemical reactions in the body Levels of electrolytes in the body can become too low → that can happen when the amount of water in your body changes causing dehydration

  16. 9. Dehydration • What is dehydration? 3 • Dehydration occurs when you use or lose more fluid than you take in, and your body doesn't have enough water and other fluids to carry out its normal functions. • Causes of Dehydration 10, 11 • Sweating too much, for example, from exercising in hot weather • Vomiting, diarrhea, fever • Increased urination • No access to safe drink water • Signs of mild to moderate dehydration10, 11 • Thirst, dry mouth and skin • Dry or sticky mouth • Not urinating much, darker yellow urine • Headache Signsofseveredehydration ! Oral rehydration therapy is recommended since 1970s to prevent and treat diarrhoeal dehydration. 3,12

  17. 10. Diarrhea • What is diarrhea? 13 • Diarrhea is defined as the passage of three or more loose or liquid stools per day (or more frequent passage than is normal for the individual). • If your body does not absorb the fluids, or if your digestive system produces extra fluids, stools will be loose and watery. • Acute diarrhea lasts a short time, usually only 1 or 2 days. • Diarrhea that lasts for at least 4 weeks is called chronic diarrhea. • Causes of Diarrhea 13 • Bacteria from contaminatedfoods or water • Viruses • Parasites • Medicines such as antibiotics • Diseases that affect the stomach, small intestine or colon • Problems digesting certain foods • The most severe threat posed by diarrhea is dehydration. • During a diarrheal episode, water and electrolytes are lost through liquid stools, vomit, sweat, urine and breathing. • The only effective treatment for dehydration is to replace lost fluids and lost electrolytes (e.g. with )

  18. 10. Diarrhea 14 • Diarrhea kills more children than malaria, measles and AIDS combined 14, 15 • Diarrhea kills 2195 children every day 15, 16 • Diarrhea is a leading cause of malnutrition in children under 5 years old 13, 15

  19. 11. Good to Know PREVENTION OF DIARRHEA 17 Breastfeeding • Exclusively breastfeeding during the first 6 months of life • Immunological properties: protection of diarrhea • Breastfeeding is clean (no use of bottles, water etc. which are easily contaminated) • Good feeding practices • Should be started when a child is 6 months old • Using hygienic practice when preparing food • Soft mashed foods (e.g. cereals), eggs, meat, fish and fruits, vegetables • Use of safe water • Collect and store water in clean containers • Boil water to kill bacteria • Keep animals away from protected water sources • Regular handwashing • After defecation, after cleaning a child who has defecated, before preparing food/eating • Use soap!

  20. 12. Complementary Treatment INDICATION: Fluid loss • Electrolyte-glucose mixture to support water balance + • Improvement of the immune function • Strengthens the bodydefense

  21. 13. References 1Hydration for Health Initiative (2017): Water and hydration: Physiological basis in adults. 2 WHO & UNICEF (2006): Oral rehydration salts. Production of the new ORS. 3 Mayo Clinic (2017): Dehydration. Symptoms and causes. 4U.S. National Library of Medicine Medline Plus (2017): Sodium. 5Natural Medicines TM (2017): Potassium. 6 U.S. National Library of Medicine Medline Plus (2017): Chloride. 7 Khan WU (2011): Zinc supplementation in the management of diarrhoea. WHO. 8 Gale Encyclopedia of Medicine (2008): Electrolytes. 9 Medline Plus (2017): Fluid and Electrolyte Balance. 10 Medline Plus (2017): Dehydration.

  22. 13. References 11 Mayo Clinic (2017): Dehydration. Diagnosis and treatment. 12 Munos MK (2010:) The effect of oral rehydration solution and recommended home fluids on diarrhoea mortality. Int J Epidemiol. 39. i75-i87. 13 WHO (2017): Diarrhoeal disease. Fact sheet. 14 UNICEF (2011): Workshop Diarrhea. 15 Liu L (2012): Global, regional and national causes of child mortality. Lancet. 379. 2151-2161. 16 U.S. Department of Health and Human Services. Diarrhea: Common Illness, Global Killer 17 WHO (2005): The treatment of diarrhoea. A manual for physicians and other senior health workers. Department of Child healthandAdolescenthealthand Development.

  23. Join DenkPharma Our contributions to keeping you healthy: • affordable pharmaceuticals for your therapy • German high premium quality for tablets, sachets, packaging, studies, consultation, availability, support, etc… • raise awareness by conducting Check Up Days (blood glucose, blood pressure, cholesterol and triglyceride) • constantly enhancing the product portfolio

  24. HEALTHCARE MADE IN GERMANY since 1948