The StarNet Case Control Study. Investigating the Effects of Genes and Environment on Smoking Behavior. Overview of Research Study. Phase 1: Designing the StarNet Case Control Study
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Investigating the Effects of Genes and Environment on Smoking Behavior
Controls are people who initiated smoking but never became smokers.Research Question: What genetic and environmental exposures are associated with people moving from smoking initiation to maintenance?
Stages of Smoking
Non-smokers never smoked, or tried smoking but did not continue
Former smokers successful quitters
Subjects will complete a questionnaire that asks about environmental factors
Subjects will be genotyped for a few candidate genes
Outcome: Moving from smoking initiation to maintenance
Exposures:Several environmental factors and a few genes involved in the reward pathway or nicotine metabolism
What do we want to know?