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Fig 3

Fig 3. A. Effect on AKT and ERK signalling pathways. MCF7-AROM1. BT474-AROM3. LTED. pAKT. pAKT. pAKT. AKT. AKT. AKT. pERK1/2. pERK1/2. pERK1/2. ERK1/2. ERK1/2. ERK1/2. ER. ER. ER. pS6 S240/S244. pS6 S240/S244. pS6 S240/S244. Actin. Actin. Actin.

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Fig 3

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  1. Fig 3 A Effect on AKT and ERK signalling pathways MCF7-AROM1 BT474-AROM3 LTED pAKT pAKT pAKT AKT AKT AKT pERK1/2 pERK1/2 pERK1/2 ERK1/2 ERK1/2 ERK1/2 ER ER ER pS6 S240/S244 pS6 S240/S244 pS6 S240/S244 Actin Actin Actin Effect on IGF1R signalling pathways B MCF7-AROM1 LTED IGF1R IGF1R 0.50 0.37 1.38 0.83 0.76 0.12 1.38 0.18 1.65 0.36 0.34 0.46 0.09 0.19 0.92 1.71 1.11 0.84 0.86 0.91 0.18 0.60 0.26 0.58 1.21 0.27 1.36 0.00 0.00 0.87 0.61 0.31 1.64 1.03 0.68 0.10 0.36 0.99 1.49 0.16 0.77 2.33 0.13 0.54 1.75 1.80 0.58 1.16 0.22 0.29 1.77 1.13 2.59 1.29 0.71 0.03 0.55 0.57 0.35 1.26 0.49 0.19 0.71 0.20 0.66 0.55 1.67 0.44 0.85 0.73 0.06 0.45 1.57 0.40 0.84 1.31 1.21 1.26 1.90 0.73 1.02 0.58 0.08 0.12 2.00 0.63 0.97 1.04 1.55 0.49 0.55 0.88 1.52 1.57 0.78 1.13 0.47 0.00 0.81 0.00 0.20 0.46 0.85 1.29 0.75 1.63 1.01 1.57 0.32 0.13 0.36 0.16 0.67 0.21 0.73 0.08 0.06 0.42 0.67 0.81 1.70 1.69 0.47 0.71 0.96 1.79 0.60 0.67 1.17 0.29 0.62 0.19 0.93 0.69 0.36 0.96 0.09 0.81 0.00 0.08 0.59 0.14 0.24 0.00 0.15 0.50 1.57 0.92 1.46 0.64 1.95 1.10 1.35 1.53 0.68 0.76 0.89 0.47 1.03 0.86 0.05 0.66 0.20 0.37 0.27 0.03 0.81 0.42 0.32 0.53 0.58 0.98 0.83 0.51 1.10 0.32 1.63 0.67 0.34 0.50 0.32 0.18 0.62 0.00 0.23 0.72 0.22 0.49 1.09 1.31 0.05 1.11 1.01 1.77 0.97 0.93 IRS1 IRS1 IRS2 IRS2 DCC-FBS RAD001 2nM E2 0.01nM 4OH-Tam 10nM DCC-FBS RAD001 2nM E2 0.01nM 4OH-Tam 10nM DCC-FBS RAD001 2nM E2 0.01nM 4OH-Tam 10nM + - - - + - - - + - - - + + - - + + - - + + - - + - + - + - + - + - + - + + + - + + + - + + + - + - + + + - + + + - + + + + + + + + + + + + + + Actin Actin Effect on HER signalling pathways C + - + - + + - + - + + - + - + + - + - + + - + - + + + + - + + + + - + + + + - + + + + - + + + + - + DCC-FBS RAD001 2nM And 10nM Let 100nM 4OH-Tam 10nM DCC-FBS RAD001 2nM And 10nM Let 100nM 4OH-Tam 10nM DCC-FBS RAD001 2nM And 10nM Let 100nM 4OH-Tam 10nM DCC-FBS RAD001 2nM And 10nM Let 100nM 4OH-Tam 10nM DCC-FBS RAD001 2nM And 10nM Let 100nM 4OH-Tam 10nM + - - - - + - - - - + - - - - + - - - - + - - - - + + - - - + + - - - + + - - - + + - - - + + - - - + - + - - + - + - - + - + - - + - + - - + - + - - + + + - - + + + - - + + + - - + + + - - + + + - - + - + + - + - + + - + - + + - + - + + - + - + + - + + + + - + + + + - + + + + - + + + + - + + + + - BT474-AROM3 MCF7-AROM1 LTED pHER2 pHER2 pHER2 HER2 HER2 HER2 pHER3 pHER3 pHER3 HER3 HER3 HER3 Actin Actin Actin

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