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Gene expression (fold-increase vs. untreated control)

a. Insulin/Glucose axis-unrelated genes. Insulin/Glucose axis-related genes. > 7-fold. Gene expression (fold-increase vs. untreated control). Supplemental Figure 1. FASN/mRNA PPIA mRNA in OM adipose tissue. Fasting glucose (mg/dl). b. Supplemental Figure 1. a. Adipocytes.

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Gene expression (fold-increase vs. untreated control)

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  1. a Insulin/Glucose axis-unrelated genes Insulin/Glucose axis-related genes > 7-fold Gene expression (fold-increase vs. untreated control) Supplemental Figure 1

  2. FASN/mRNA PPIA mRNA in OM adipose tissue Fasting glucose (mg/dl) b Supplemental Figure 1

  3. a Adipocytes Tumor cells Control Day 0 DNA FASN DNA FASN 3T3-L1 MCF-7 CELL GROWTH INHIBITION ADIPOCYTE MATURATION FASN down-regulation FASN up-regulation 3T3-L1 MCF-7 DNA FASN DNA FASN Day 9 Metformin Supplemental Figure 2

  4. b + + ? EXERCISE CALORIE DEPRIVATION AMP METFORMIN ATP THIAZOLIDINEDIONES Other AMPK activators AMPK LOW-ENERGY STATUS INACTIVE TSC1 TSC2 P P ACUTE EFFECT AMPK ACTIVE P P mTOR ACACA activity CHRONIC EFFECTS 4E-BP1 S6K1 Protein synthesis initiation FASN gene transcription FASN mRNA FASN mRNA translation FASN promoter Supplemental Figure 2

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