1 / 4

Nodular Lymphocyte-Predominant Hodgkin’s Disease

Nodular Lymphocyte-Predominant Hodgkin’s Disease. A distinct entity. Characteristics. Clonal proliferation of B cells Distinctive immunophenotype Tumor cells Express: J chain, CD45 and ema Do not express: CD30 and CD15 Normal markers in Sternberg-Reed cells Chronic, relapsing course

tyrell
Download Presentation

Nodular Lymphocyte-Predominant Hodgkin’s Disease

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Nodular Lymphocyte-Predominant Hodgkin’s Disease

  2. A distinct entity

  3. Characteristics • Clonal proliferation of B cells • Distinctive immunophenotype • Tumor cells • Express: J chain, CD45 and ema • Do not express: CD30 and CD15 • Normal markers in Sternberg-Reed cells • Chronic, relapsing course • Sometimes  diffuse large B cell lymphoma Source: p. 699

  4. Treatment • Controversial • >80% long term survival (regardless of therapy) • CURRENT strategies • No treatment + close follow-up • Radiotherapy – for localized disease • Regimen for Classical HD – for disseminated disease Source: p. 699-700

More Related