Surgery for inflammatory bowel disease
1 / 79

Surgery for Inflammatory Bowel disease - PowerPoint PPT Presentation

  • Updated On :

Surgery for Inflammatory Bowel disease. E .Condon Beaumont Hospital/ RCSI, Dublin. Colorectal Department. Overview. Types Diverticular disease Ulcerative colitis Crohns Disease Ischemic colitis Amoebiasis Pseudomembranous colitis Radiation enterocolitis. Diverticular disease.

I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
Download Presentation

PowerPoint Slideshow about ' Surgery for Inflammatory Bowel disease' - Olivia

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.

- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
Surgery for inflammatory bowel disease l.jpg

Surgery for Inflammatory Bowel disease

E .Condon

Beaumont Hospital/ RCSI, Dublin.

Colorectal Department

Colorectal Surgery Department

Overview l.jpg


  • Diverticular disease

  • Ulcerative colitis

  • Crohns Disease

  • Ischemic colitis

  • Amoebiasis

  • Pseudomembranous colitis

  • Radiation enterocolitis

Colorectal Surgery Department

Diverticular disease l.jpg
Diverticular disease

  • Definition ; Herniation of bowel mucosa through the bowel wall (Blood vessels)

  • Sites sigmoid and descending colon

  • Raised intraluminal pressure

  • Segmental contraction

  • 30% of all patients over 60 in the western world

Colorectal Surgery Department

Presentations l.jpg

  • Acute diverticulitis

  • Chronic diverticulitis

    Complications of diverticulitis

  • Obstruction

  • Abscess formation

  • Diffuse peritonitis

  • Fistula

  • Haemorrhage

Colorectal Surgery Department

Diagnosis l.jpg

  • Bloods

  • CT

  • Barium

  • Colonoscopy

Colorectal Surgery Department

Indications for surgery l.jpg
Indications for surgery

  • Acute diverticulitis- all complications except abscess

  • Chronic diverticulitis – Persistent Pain /anemia

  • 2 episodes of mild diveriticulitis

Colorectal Surgery Department

Surgical options l.jpg
Surgical options

  • Laparoscopy

  • Sigmoid colectomy

  • Hartmans

  • Anterior resection

  • Transverse colostomy and peritoneal toilet

Colorectal Surgery Department

Operating theatre l.jpg
Operating theatre

Colorectal Surgery Department

Best operation to do l.jpg
Best operation to Do??

  • Sigmoid colectomy

  • Anterior resection

  • Hartmans

Colorectal Surgery Department

Ulcerative colitis l.jpg
Ulcerative colitis

  • Definition; disease of unknown cause charecterised by non specific and diffuse inflammatory changes of the mucosa of the rectum and the large bowel

  • Causes

  • Infection

  • Allergy

  • Autoimmunity

Colorectal Surgery Department

Slide11 l.jpg

  • Disease is mucosal

  • Serosa – no serositis

  • Segment usually descending colon

  • Mucosa reddened friable

  • Pseudopolyps

  • Microscopic – inflammatory cellular infiltration of mucosa and the submucosa crypt abscesses dysplasia transmural inflammation

Colorectal Surgery Department

Symptoms l.jpg

  • Bloody diarrhoea

  • Abdominal discomfort

  • Diagnosis – colonoscopy barium enema

  • Treatment

  • Steroids local systemic


  • Bowel rest

Colorectal Surgery Department

Indications for surgery13 l.jpg
Indications for surgery

  • Relative indications

    • Chronic invalidisim- severe colitis few years chronic ill health anemia

    • Relapsing colitis 2 severe episodes in 3years

    • Persistent steroids – the complications of roids

  • Absolute indications

    • Failure of medical therapy in acute severe attack

    • Perforation

    • Toxic megacolon

Colorectal Surgery Department

Operating theatre14 l.jpg
Operating theatre

Colorectal Surgery Department

Surgical options15 l.jpg
Surgical Options

  • 1. ileostomy

  • 2.Proctocolectomy- permanent ileosotmy

  • 3.Total colectomy- later ileorectal anastomosis

  • 4.Pouch 2 stage / 3 stage

  • 5. Total colectomy with ileostomy

Colorectal Surgery Department

Best surgery l.jpg
Best Surgery

  • Pouch 3 stage

  • Proctocolectomy- permanent ileostomy

Colorectal Surgery Department

Pouchs l.jpg

  • J Pouchs

  • Advantages no stoma / continence

  • Complications

  • Infertility

  • Pouchitis

  • Pouch failure 10 years 18 %

  • crohns

Colorectal Surgery Department

Crohns l.jpg

  • Definition ; regional enteritis granulomatous entercolitis

  • Unknown cause ( toothpaste)

  • Characterised by discontinuous full thickness inflammation anywhere in the GI tract

  • Common sites ileocaecal skip lesions in the ileum and perianal suppuration

Colorectal Surgery Department

Crohns19 l.jpg

  • Key histological differences

  • Granulomas

  • Fibrosis

  • Full thickness

  • Fistulas

Colorectal Surgery Department

Presentation l.jpg

  • Usually regional ileitis

  • Like appendicitis

  • Mass RIF

  • Diarrhoea

  • Obstruction

  • Perforation

  • Fistula

  • Perianal Crohns

  • Anemia

Colorectal Surgery Department

Indication for surgery l.jpg
Indication for Surgery

  • Surgery nearly always treatment of choice 80-90% of cases ultimately require surgery

  • Perianal disease and fistulas

Colorectal Surgery Department

Operating theatre22 l.jpg
Operating theatre

Colorectal Surgery Department

Surgical options23 l.jpg
Surgical options

  • Regional ileitis

    • Ileal resection primary reanastomosis

    • Right Hemicolectomy

  • Colonic crohns

    • Panproctocolectomy and permanent ileostomy

    • Perianal crohns fistulotomy

Colorectal Surgery Department

Ischemic colitis l.jpg
Ischemic colitis

  • Inflammatory response in the colon following an ischemic episodeowing to occlusion or narrowing of the inferior mesenteric artery

  • Causes



    surgery/ trauma

    Severity depends on the duration and the patency of the marginal artery

Colorectal Surgery Department

Presentations28 l.jpg

  • 2 phases

    • Mucosal gangrene

    • Secondary invasion with organisims which accelerate the gangerenous process

  • Ischemic colitis with gangerene

  • Transient ischemic colitis

  • Stricture

Colorectal Surgery Department

Surgical options29 l.jpg
Surgical options

  • Transient ischemic colitis –mesenteric angiogram stenting of affected segment – primary vascular repair

    excision of the affected segment

    Ischemic colitis with gangarene excision total colectomy with permanent ileosotomy 80% mortality

Colorectal Surgery Department

Amoebiasis l.jpg

  • Entamoeba histolytica

  • Cyst water /faecal oral /sexual

  • Colitis

  • Transmural colitis with perforation

  • Infamatory mass

  • Hepatic abscess

  • Stool exam ct scan -flagyl

  • Perforation -resection

Colorectal Surgery Department

Pseudomembranous colitis l.jpg
Pseudomembranous colitis

  • C difficile – cephalosporins

  • Diarrhea

  • Bowel rest / flagyl/ vancomycin ORALLY

  • Toxic dilatation > 6 cm impending perforation

  • PFA CT

  • Proctocoletomy end ielostomy

Colorectal Surgery Department

Radiation enteritis l.jpg
Radiation enteritis

  • Usually SB following therapeutic radiation less common now

  • Diarrhoea /obstruction

  • Ileitis /proctitis

  • Treatment NSAIDS steroid rarely resect except for strictures

Colorectal Surgery Department

General advise l.jpg
General Advise

  • Categorise youre answers

    eg intestinal obstruction

    in the lumen

    outside the lumen

    in the wall

    in medical

    Be logical and organised

Colorectal Surgery Department

Answer questions l.jpg
Answer questions

  • Definition

  • Pathology

  • Classification

  • Causes

  • Differential diagnosis

  • Symptoms signs

  • Complications S&S of complications

  • Investigations bloods radiology surgical

  • Management medical/ surgical

  • prognosis

Colorectal Surgery Department

Questions l.jpg


Good Luck!!

Colorectal Surgery Department

Preoperative mri l.jpg
Preoperative MRI

  • Preop MRI scanning allows selection of patients who will benefit from a course of preoperative radiotherapy

  • T3 or T4 primary tumour or node positive patients

lymph node

Colorectal Surgery Department

Slide37 l.jpg

  • Main indication in rectal cancer T3 or not T3

  • Every patient with rectal CA should have pre-op MRI to decide whether or not neoadjuvant therapy is indicated

Colorectal Surgery Department

Pet scanning l.jpg
PET Scanning

Local recurrence at the splenic flexure

Colorectal Surgery Department

Current indications for pet scanning l.jpg
Current indications for PET Scanning

  • FDG PET is approved detection and localisation of recurrent colorectal cancer in patients with rising CEA levels and indeterminate findings on standard imaging studies

  • Indications may expand in the future but its final role is still to be determined

  • Radilogical imaging modalities in the diagnosis and management of colorectal cancer , Heamatology clinics of north america 202 16;90 875-95

Colorectal Surgery Department

Virtual colonoscopy l.jpg
Virtual Colonoscopy

Colorectal Surgery Department

Virtual colonoscopy how does it work l.jpg
Virtual colonoscopy – how does it work

  • Virtual Colonoscopy is a promising new method for detecting colorectal polyps and cancers. Air is insufflated into a cleansed colon, and high resolution, thinly-collimated spiral CT slices are acquired. The two dimensional slices, as well as the post-processed "fly-through" virtual colonoscopic images, are examined for polyps and tumors.

Colorectal Surgery Department

Virtual colonoscopy advantages l.jpg
Virtual Colonoscopy- advantages

  • Advantages of Virtual Colonoscopy Virtual Colonoscopy is minimally invasive, and does not carry the low but real (1 in 1500) risk of perforation associated with Conventional Colonoscopy. It is well tolerated by patients and does not require sedation. It is capable of evaluating the colon upstream from obstructing lesions that prevent passage of an endoscope. Virtual Colonoscopy is significantly less expensive than Conventional Colonoscopy.

Colorectal Surgery Department

Virtual colonoscopy disadvantages l.jpg
Virtual Colonoscopy-Disadvantages

  • The dose of ionizing radiation is less than that of a conventional abdominal CT, and is comparable to obtaining a supine and upright plain film exam of the abdomen.

  • Colonoscopy by CT does not provide the same information as Conventional Colonoscopy. Mucosal detail and color is not visible which limits the characterization of lesions. In addition, the detection of small polyps is inferior

Colorectal Surgery Department

Virtual colonoscopy disadvantages44 l.jpg
Virtual colonoscopy-disadvantages

  • As with any procedure, including Conventional Colonoscopy, there are no guarantees that all clinically significant growths will be detected. It should be remembered than between 10 and 20% of all polyps, and up to 5% of colon cancers are missed, even on Conventional Colonoscopy.

  • Virtual Colonoscopy (like the Barium Enema) is a diagnostic not therapeutic technique. All patients in whom polyps are identified would need to undergo Conventional Colonoscopy for removal.

Colorectal Surgery Department

Virtual colonoscopy current indications l.jpg
Virtual Colonoscopy Current indications

  • Frail elderly patients

  • Occlusive cancer for detection of other lesions

  • Previous incomplete colonoscopy

Colorectal Surgery Department

Surgical advances l.jpg
Surgical Advances





Colorectal Surgery Department

Local resection of low rectal tumours l.jpg
Local Resection of low rectal tumours

Transanal resection or TEMS (Trans anal endoscopic microsurgery) allows anal sphincter preservation while avoiding the risks of abdominal surgery

- but its oncologic acceptability remains controversial.

  • No randomised trials exist

  • Safe application of this technique requires accurate preoperative staging, careful transanal resection, and meticulous histological examination. Factors that increase the risk of recurrence following local resection include T stage, poor histological grade, lymphovascular invasion, and positive excision margins

Colorectal Surgery Department

Local resection for low rectal tumours l.jpg
Local resection for low rectal tumours

  • Recent meta-analysis indicates that local recurrence occurs in

  • 9.7% of patients (range 0%-24%) of patients with T1 tumors

  • 25% (range 0%-67%) of those with T2 tumors

  • 38% (range 0%-100%) of those with T3 tumors

  • Sengupta S,Tjandra JJ. Local excision of rectal cancer: what is the evidence? Dis Colon Rectum. 2001;44:1345-1361.

Colorectal Surgery Department

Transanal endoscopic microsurgery l.jpg
Transanal Endoscopic Microsurgery

Colorectal Surgery Department

Total mesorectal excision l.jpg
Total Mesorectal Excision

Colorectal Surgery Department

Total mesorectal excision51 l.jpg
Total Mesorectal Excision

  • Definition; en bloc resection of the rectum and its enveloping mesentery to the level of the pelvic floor with a negative distal and radial resection margin.

  • reduces the incidence of local recurrence to less than 10% without the use of adjuvant treatment. Martling AL, Holm T, Rutqvist LE, et al.Stockholm Colorectal Cancer Study Group, Basingstoke Bowel Cancer Research Project. Lancet. 2000;356:93-96

Colorectal Surgery Department

Total mesorectal excision52 l.jpg
Total Mesorectal Excision

Colorectal Surgery Department

Coloanal j pouch l.jpg

Coloanal J pouch

Colorectal Surgery Department

Slide54 l.jpg

Criteria necessary for successful sphincter preservation in rectal cancer

  • No pre-operative alteration of sphincter mechanism.

  • TME and nerve sparing surgery.

  • No damage to levator ani.

  • Preservation of at least half of the internal sphincter.

  • Low rate of anastomotic leakage.

  • Low rate of pelvic sepsis.

  • Low rate of anastomotic stricture.

  • Allow good bowel function.

Colorectal Surgery Department

Slide55 l.jpg

How can we improve function? rectal cancer

  • Rectal cancer surgery may result in poor post-operative quality of life in survivors as a result of frequency, urgency and faecal soiling. McDonald et al BJS 1983

  • Postoperative function and continence after low anterior resection are significantly improved by a colonic pouch. Parc et al BJS 1986 Lazorthes et al BJS 1986 Mantyh et al DCR 2001

Colorectal Surgery Department

Slide56 l.jpg

Coloanal J pouch vs. direct low anastomosis rectal cancer

  • Lower morbidity.

  • Better early function.

  • Improvement of function persists with time.

  • Lazorthes F. et al. Br J Surg 1997

  • Dehni N. et al. Dis Colon Rectum 1998

  • Harris G.J.C. et al. Br J Surg 2001

  • Age not a contra-indication.Dehni N. et al. Am J Surg 1998

Colorectal Surgery Department

Slide57 l.jpg

Coloanal J pouch: functional results rectal cancer

  • Bowel movements 2.1 per 24 h

  • Continence

    • Perfect or good 82%

    • Soiling 14%

    • Frequent fecal incontinence 4%

  • Protecting PAD

    • Never 71%

    • As a safety 11%

    • Needed 18%

Colorectal Surgery Department

Slide58 l.jpg

Coloanal J pouch: functional results rectal cancer

  • Normal discrimination between 95%

  • flatus and stool

  • Urgency 4%

  • Fragmentation of stools 21%

  • Suppository or enema 20%

  • to elicit evacuation

Colorectal Surgery Department

Slide59 l.jpg

Conclusion rectal cancer

  • Preoperative radiotherapy is followed by only minor deterioration in post-op anorectal function if colonic pouch anal anastomosis is performed.

  • Reconstructive technique of choice in preoperatively irradiated patients.




exclusion of

anal sphincter

from field of


Colorectal Surgery Department

Laparoscopic surgery l.jpg
Laparoscopic Surgery rectal cancer



*Nair RG et al. British Journal of Surgery 1997;84:1369-98

Colorectal Surgery Department

Laparoscopic colectomy essential questions l.jpg
Laparoscopic colectomy -Essential Questions rectal cancer

Is it safe?

  • Clinically

  • Technically

  • Economically

  • Oncologically

Colorectal Surgery Department

Laparoscopic colorectal surgery l.jpg
Laparoscopic Colorectal Surgery rectal cancer

  • Early mobilisation

  • Shorter ileus

  • Reduced opiate requirement

  • Lower cardiorespiratory morbidity

  • Reduced hospital stay

  • Cosmetically better

Potential advantages

Colorectal Surgery Department

Laparoscopic colorectal surgery63 l.jpg
Laparoscopic Colorectal Surgery rectal cancer

  • Technically demanding

  • Difficult orientation

  • Increased operative time

  • Increased tumour dissemination

  • Increased postoperative morbidity

Potential disadvantages

Colorectal Surgery Department

Slide64 l.jpg

Patterns of Recurrence and Survival after Laparoscopic and Conventional Resections for Colorectal CarcinomaJohn E Hartley, et al

Annals of Surgery 2001;132:181-186

Colorectal Surgery Department

Methods 3 lap assisted l.jpg
Methods 3 - Lap. Assisted Conventional Resections for Colorectal Carcinoma

Operative Technique

  • “Laparoscopic principles are Open principles”

  • Laparoscopic Mobilisation

  • Intracoporeal vessel division

  • Intra /Extracorporeal bowel division

  • Extracorporeal stapled anastomosis

Colorectal Surgery Department

Results 1 demographics l.jpg
Results 1 - Demographics Conventional Resections for Colorectal Carcinoma

Laparoscopic Open

n 58 53

Age 70 (51-87) 72 (36-90)

Sex M:F 38:20 42:11


Dukes A 12 10

Dukes B 19 15

Dukes C 22 21

Dukes D 5 7

Colorectal Surgery Department

Results 2 operative l.jpg
Results 2 - Operative Conventional Resections for Colorectal Carcinoma

Laparoscopic Open

Operative Time 185 (80-330) 122 (70-285)*

*p<0.05 Mann Whitney

CONVERSIONS n=20 (34%)

Crude survival kaplan meier l.jpg
Crude Survival - Kaplan-Meier Conventional Resections for Colorectal Carcinoma


p=0.6264. Log Rank Test


Probability of Survival



















Number at risk






Recurrence l.jpg
Recurrence Conventional Resections for Colorectal Carcinoma

Open Lap. Assisted

Rectal Cancer

n 27 28

Local + distant recurrence 2 1

Local recurrence in isolation 1 1

Total 3 (11.1%) 2 (7.1%)

Wound recurrence (all patients) 3 (5.6%) 1 (1.7%)

Colorectal Surgery Department

Recurrence70 l.jpg
Recurrence Conventional Resections for Colorectal Carcinoma

  • Rectal Cancer

    • Local recurrence 3 of 27 open 11.1%

    • 2 of 28 lap. assisted 7.1%

  • Wound recurrence

    • Open 3 of 53 5.6%

    • Lap. assisted 1 of 58 1.7%

Colorectal Surgery Department

Conclusions l.jpg
Conclusions Conventional Resections for Colorectal Carcinoma

  • Oncological outcome at two years is not compromised by an “all-comers” laparoscopic assisted approach

  • Wound recurrence is a feature of both open and laparoscopic surgery for advanced disease

Colorectal Surgery Department

Conclusions current status l.jpg
Conclusions - Current status Conventional Resections for Colorectal Carcinoma

  • Laparoscopic surgery for cancer is still in the development phase

  • Convincing data that it is safe and new suggestions that survival may be improved

  • Very operator dependant

  • Needs strict control - ongoing audit and supervision.

Colorectal Surgery Department

Slide73 l.jpg

“The Ongoing Randomized Trials” Conventional Resections for Colorectal Carcinoma






? 2003 AD

Colorectal Surgery Department

Single positive randomised trial l.jpg
Single Positive Randomised Trial Conventional Resections for Colorectal Carcinoma

  • Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial.

  • Lacy AM et al

  • Lancet 2002 Jun 29;359(9325):2224-9

  • Multicentre trials not yet reported CLASICC etc

Colorectal Surgery Department

Lacy trial continued l.jpg
Lacy trial continued Conventional Resections for Colorectal Carcinoma

  • 219 patients (111 laparoscopic)

  • Improved short term variables and

  • Improved survival in laparoscopic group particularly for Stage III (ie node +ve) cancers

  • Very significant data if can be replicated.

    • Single centre with enthusiast

    • Small numbers

Colorectal Surgery Department

Consensus statements l.jpg
Consensus Statements Conventional Resections for Colorectal Carcinoma

  • “The use of laparoscopic surgery in the curative treatment of colorectal cancer remains controversial. However, assuming appropriate adherence to the principles of surgical oncology there appears to be no difference in the adequacy of tumour resection and adjacent lymph nodes. In addition, the short term outcome appears comparable to open surgery in respect of morbidity, mortality and cancer recurrence including wound deposits.”


Colorectal Surgery Department

Slide77 l.jpg

Laparoscopic Assisted Colectomy Conventional Resections for Colorectal Carcinoma

  • Three port technique

  • Laparoscopic

    • identification of anatomy

    • division of vascular pedicle

    • mobilisation of colon, mesentery and relevant flexure

  • Extracorporeal

    • delivery of specimen

    • determination of margins

    • anastomosis

    • closure of mesenteric defect

  • Colorectal Surgery Department

    Slide78 l.jpg

    Colorectal Surgery Department Conventional Resections for Colorectal Carcinoma

    Operating theatre79 l.jpg
    Operating theatre Conventional Resections for Colorectal Carcinoma

    Colorectal Surgery Department