More Powerful Genome-wide Association Methods for Case-control Data. Robert C. Elston, PhD Case Western Reserve University Cleveland Ohio. Kim S, Morris NJ, Won S, Elston RC Genetic Epidemiology, in press.
Robert C. Elston, PhD
Case Western Reserve University
Genetic Epidemiology, in pressSingle-marker and two-marker association tests for unphased case-control genotype data, with a power comparison
HWD trend test
LD contrast test
d. genotype frequency test
haplotype-based test with HWE
g. phase-known genotype-based test
_ cases and controls tests the null hypothesis H
E.g. The HWD contrast test adjusted for allele frequency information which is used in the first stage can be performed by the test of
For each of the four disease models, parameters were set as follows:
pD = 0.2, pA = 0.3, K = 0.05, DXD = 0.048(D’ = 0.8), n = 2,000 (500 for recessive), α = 0.05/500,000
Empirical power is obtained by the ratio of the number of rejected replicates to the total 100,000 replicates.
http://darwin.case.edu/sage.html set up the true single-marker