Per2

1. A B Per2 Per2 Bmal1 Bmal1 Per3 Per1 CSNK1 Rev-erb Cry1 Per3 Cry2 Cry2 Clock Cry1 Rev-erb Clock Ror Ror Per1 CSNK1 C D 0 0 0 0 0.1 0.2 0.3 0.1 0.2 0.3 0.1 0.2 0.3 0.1 0.2 0.3 0.05 0.15 0.25 0.35 0.05 0.15 0.25 0.35 0.05 0.15 0.25 0.35 0.05 0.15 0.25 0.35 Per1 Per3 Per2 Clock Per3 Cry1 Cry2 Clock CSNK1 Cry1 Ror Cry2 Per1 CSNK1 Rev-erb Rev-erb Per2 Bmal1 Bmal1 Ror Supplemental Figure 3.Cross-correlation analyses of clock gene expression in human peripheral blood leukocytes challenged with endotoxin or saline at 09:00 h or 21:00 h. The gene expression data for each subject was cross-correlated across all studied genes within a subject. The cross-correlation data were normalized to one, where one represents a perfect correlation between gene responses. The correlation matrices for (A) placebo day and night subjects (09:00 h plus 21:00 h saline infusion time; n=3), (B) endotoxin day subjects (09:00 h infusion; n=4), (C) endotoxin night subjects (21:00 h infusion; n=3), (D) endotoxin day and night subjects (09:00 h plus 21:00 h endotoxin infusion time; n=7), were clustered into a tree form.