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Analysis of genetic interaction networks in S. cerevisiae

Analysis of genetic interaction networks in S. cerevisiae

Analysis of genetic interaction networks in S. cerevisiae. Fritz Roth Harvard Medical School Biological Chemistry & Molecular Pharmacology Network Science May 2007. A Simplified Organism. Vertices (or nodes ) are genes Edges (or links ) are gene pairs. Outline. Background:

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1.17k views • 101 slides
Cytoscape and networks

Cytoscape and networks

Cytoscape and networks. David Amar http://tau.ac.il /~davidama/bioinfo_tutorials. Network biology. Overview: systems biology Represent molecular entities Represent interactions Two main data types Pathways Interaction networks. Biological interaction networks.

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1.32k views • 86 slides
Phenotype and the Interaction of Genetic Perturbations

Phenotype and the Interaction of Genetic Perturbations

Phenotype and the Interaction of Genetic Perturbations. Informatics for System Genetics. Phenotype and the Interaction of Genetic Perturbations. Introduction Generalized derivation of genetic-interaction networks Generation of a yeast invasiveness network

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792 views • 55 slides
The FlyBase Consortium: Harvard University University of Bloomington-Indiana

The FlyBase Consortium: Harvard University University of Bloomington-Indiana

The FlyBase Consortium: Harvard University University of Bloomington-Indiana University of California-Berkeley Cambridge University. FlyBase includes 78,804 named alleles of 19,053 Drosophilid genes C LASSICAL A LLELES 61,286 e.g. sty S73 (EMS) G ENETICALLY E NGINEERED A LLELES

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229 views • 22 slides
Genetic interactions

Genetic interactions

Genetic interactions. Epistasis KO of gene A has phenotype a , KO of gene B has phenotype b , KO of A+B has phenotype b . Genetic interaction KO of gene A and B together has different phenotype from the sum of A and B individually. Special cases: buffering, synthetic interaction.

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432 views • 14 slides
CDC73 RRP6 SET2 RTF1 CDC73 RTF1 CDC73 RTT103 CDC73 RTT109 CDC73 RUD3 CDC73 RXT2 CDC73 SAP30

CDC73 RRP6 SET2 RTF1 CDC73 RTF1 CDC73 RTT103 CDC73 RTT109 CDC73 RUD3 CDC73 RXT2 CDC73 SAP30

Supplemental Table S1. Genetic Interactors of SET2 , DST1 , and CDC73. Query Gene. Genetic Interaction. Query Gene. Genetic Interaction. Query Gene. Genetic Interaction. Query Gene. Genetic Interaction. DST1 AOR1 CDC73 AOR1 CDC73 APQ12 DST1 ARD1 SET2 ARP6 DST1 ARP6 CDC73 ARP6

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94 views • 1 slides

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