CDC73 RRP6 SET2 RTF1 CDC73 RTF1 CDC73 RTT103 CDC73 RTT109 CDC73 RUD3 CDC73 RXT2 CDC73 SAP30

1. Supplemental Table S1. Genetic Interactors of SET2, DST1, and CDC73 Query Gene Genetic Interaction Query Gene Genetic Interaction Query Gene Genetic Interaction Query Gene Genetic Interaction DST1 AOR1 CDC73 AOR1 CDC73 APQ12 DST1 ARD1 SET2 ARP6 DST1 ARP6 CDC73 ARP6 DST1 ASF1 SET2 BEM4 SET2 BRE1 SET2 BRE2 SET2 BRE5 CDC73 BTS1 CDC73 BUD13 CDC73 BUL1 SET2 CBP2 SET2 CDC73 SET2 CHD1 CDC73 CIN8 SET2 COX11 SET2 CPR1 CDC73 CTI6 CDC73 CTK1 SET2 CYT1 SET2 DCC1 SET2 DEP1 CDC73 DEP1 CDC73 DFG16 CDC73 DIA2 SET2 DNM1 CDC73 DOA1 CDC73 DOT1 CDC73 DST1 CDC73 ECM8 CDC73 ELF1 CDC73 GCR2 DST1 GGA2 SET2 GIM3 SET2 GIM5 CDC73 GLO3 CDC73 GOS1 SET2 GRE3 SET2 HAP2 CDC73 HIR2 CDC73 HIR3 SET2 HOS2 CDC73 HPC2 SET2 HST1 CDC73 RRP6 SET2 RTF1 CDC73 RTF1 CDC73 RTT103 CDC73 RTT109 CDC73 RUD3 CDC73 RXT2 CDC73 SAP30 SET2 SDC1 SET2 SEC22 DST1 SEC22 CDC73 SEC22 CDC73 SEC28 CDC73 SEM1 CDC73 SET2 SET2 SET3 SET2 SHG1 SET2 SHY1 SET2 SIF2 CDC73 SIF2 CDC73 SIN3 SET2 SNT1 CDC73 SNU66 SET2 SOH1 DST1 SOH1 CDC73 SOY1 CDC73 SPF1 SET2 SPP1 CDC73 SPT2 CDC73 SRO9 CDC73 SSN3 CDC73 SSN8 SET2 SUR1 CDC73 SUR1 SET2 SWC1 DST1 SWC1 CDC73 SWC1 SET2 SWD3 CDC73 SWF3 CDC73 SWI4 CDC73 SWI6 SET2 SWR1 CDC73 SWR1 CDC73 THP1 CDC73 THP2 CDC73 TIM18 CDC73 UBP2 CDC73 UBP6 SET2 HTZ1 DST1 HTZ1 CDC73 HTZ1 CDC73 IES2 DST1 IKI3 CDC73 IKI3 CDC73 IST3 CDC73 KEM1 SET2 KRE25 SET2 LEO1 CDC73 LEO1 SET2 LGE1 CDC73 LIP2 CDC73 LSM1 CDC73 LSM6 CDC73 LST4 DST1 LYS7 CDC73 LYS7 SET2 MAC1 CDC73 MDM38 CDC73 MED1 CDC73 MET18 CDC73 MNN10 SET2 MON2 CDC73 MRPS8 SET2 MSC1 CDC73 MSN5 CDC73 MTM1 SET2 NFI1 CDC73 NHP10 CDC73 NKP2 CDC73 NUP60 CDC73 ORM2 CDC73 PAT1 CDC73 PDA1 CDC73 PDB1 CDC73 PDE2 CDC73 PET309 CDC73 PHO23 CDC73 QRI5 DST1 RAD52 CDC73 RAD52 CDC73 RCE1 CDC73 RGP1 CDC73 RIC1 CDC73 RIM13 SET2 RIM21 CDC73 RIM21 SET2 VAC14 CDC73 VAC8 SET2 VAM3 SET2 VID21 CDC73 VID22 CDC73 VID30 DST1 VIP1 CDC73 VPS21 SET2 VPS71 DST1 VPS71 CDC73 VPS71 DST1 VPS72 CDC73 VPS72 CDC73 VPS8 CDC73 XRS2 SET2 YDL033C CDC73 YDL033C SET2 YDR116C SET2 YDR360W CDC73 YEL033W SET2 YER083C CDC73 YER084W CDC73 YER139C SET2 YGL045W SET2 YGL046W DST1 YGL066W SET2 YGR126W SET2 YHR115C SET2 YHR116W SET2 YIL112W CDC73 YKL053C-A SET2 YKL151C SET2 YLL047W CDC73 YLR168C SET2 YLR218C CDC73 YLR269C CDC73 YML012C-A SET2 YML030W CDC73 YNL140C CDC73 YNL198C CDC73 YPL182C SET2 YPR014C CDC73 YPR084W CDC73 YPT6 CDC73 YTA7 Using synthetic genetic array (SGA) technology, deleted versions of SET2, CDC73 and DST1 were used to identify double deletions that resulted in synthetic growth phenotypes. Represented here are 111, 63 and 16 genetic interactions for CDC73SET2 and DST1, respectively, that were confirmed by either tetrad dissection or random sporulation. The SET2 and CDC73 screen data represented here are also being used, along with 118 other screens, in a more general analysis of genetic interaction networks in S. cerevisiae (A. Tong et al., manuscript submitted).