Single Fiber Polymorphism in Skeletal Muscles:
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Single Fiber Polymorphism in Skeletal Muscles: A Case Example from the Lobster. Scott Medler. Wolfe, 1985 Cell Ultrastructure. Guyton and Hall 1996 Textbook of Medical Physiology 9th Ed. Guyton and Hall 1996 Textbook of Medical Physiology 9th Ed. Guyton and Hall 1996

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Single Fiber Polymorphism in Skeletal Muscles: A Case Example from the Lobster

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Single fiber polymorphism in skeletal muscles a case example from the lobster

Single Fiber Polymorphism in Skeletal Muscles:

A Case Example from the Lobster

Scott Medler


Single fiber polymorphism in skeletal muscles a case example from the lobster

Wolfe, 1985

Cell Ultrastructure


Single fiber polymorphism in skeletal muscles a case example from the lobster

Guyton and Hall 1996

Textbook of Medical Physiology

9th Ed.


Single fiber polymorphism in skeletal muscles a case example from the lobster

Guyton and Hall 1996

Textbook of Medical Physiology

9th Ed.


Single fiber polymorphism in skeletal muscles a case example from the lobster

Guyton and Hall 1996

Textbook of Medical Physiology

9th Ed.


Single fiber polymorphism in skeletal muscles a case example from the lobster

S1/S2 MHC expression


Single fiber polymorphism in skeletal muscles a case example from the lobster

Tm expression vs. MHC expression (mRNA)


Single fiber polymorphism in skeletal muscles a case example from the lobster

TnT3 protein vs. S1/S2 MHC mRNA


Single fiber polymorphism in skeletal muscles a case example from the lobster

TnI3 protein vs. S1/S2 MHC mRNA


Single fiber polymorphism in skeletal muscles a case example from the lobster

TnI2 protein vs. S1/S2 MHC mRNA


Single fiber polymorphism in skeletal muscles a case example from the lobster

CONTINUUM OF ISOFORM EXPRESSION

S1 fibers

S2 fibers

= high expression

= low expression

S1 MHC

S2 MHC

TnT3

TnT1

TnI3

TnI2

S1 Tm

S2 Tm


Single fiber polymorphism in skeletal muscles a case example from the lobster

Immediate Research Focus:

Single fiber polymorphism in lobsters

• Developmental changes in fiber phenotype

• Mechanical measurements from single fibers

• Innervation pattern and fiber phenotype

• Effects of electrical stimulation on fiber phenotype


Single fiber polymorphism in skeletal muscles a case example from the lobster

Long Term Research Interests:

• Single Fiber Polymorphism in Mammals

• Scaling Effects on Cellular/Molecular Organization of Muscles

• Physiology of Avian Flight Muscles


Single fiber polymorphism in skeletal muscles a case example from the lobster

Acknowledgements:

National Institutes of Health: Postdoctoral fellowship AR 08597-01A1 to S. Medler

National Science Foundation: IBN-0077422 to D.L. Mykles

Dr. D.L. Mykles Colorado State University

Travis Lilley Colorado State University


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