Overlap of atherosclerotic disease
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Overlap of Atherosclerotic Disease. Coronary Disease. Cerebrovascular Disease. Peripheral Arterial Disease. Patients with one manifestation often have coexistent disease in other vascular beds. 1. The 3 Steps of Platelet Aggregation. Adhesion. Aggregation. von Willebrand

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Overlap of Atherosclerotic Disease

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Overlap of atherosclerotic disease

Overlap of Atherosclerotic Disease

CoronaryDisease

CerebrovascularDisease

Peripheral Arterial Disease

Patients with one manifestation

often have coexistent disease in other vascular beds

1


The 3 steps of platelet aggregation

The 3 Steps of Platelet Aggregation

Adhesion

Aggregation

von Willebrand

Factor/GPlb bind

Platelets

Fibrinogen

Collagen

GPla/lla bind

Lipid

core

Activated

GPllb/llla

Platelet

Activation

Thrombin

ADP

5 HT

TXA2

Adaptec from Schafer. Am J Med 1996;101:199-209.


Atherosclerotic plaque

Atherosclerotic Plaque

Stable

Unstable

Lumen

Endothelium

Thrombus

Platelets

Lipid Rich Core

ThickFibrous Cap

ThinFibrous Cap

Falk E et al. Circulation. 1995;92:657-671.

3


Pressures needed to calculate the ankle brachial index abi

Pressures Needed To Calculate The Ankle-Brachial Index (ABI)

Right Arm

Pressure:

Left Arm

Pressure:

ABI

Interpretation

Above 0.90— Normal

0.71-0.90 — Mild Obstruction

0.41-0.70 — Moderate Obstruction

0.00-0.40 — Severe Obstruction

Pressure:

Pressure:

PT

PT

DP

DP

ABI = Ankle pressure/Brachial pressure


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