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MR Spectroscopy

neurons. energy. membranes. neurotransmitters. glia. Lipids/lactate. MR Spectroscopy. 1.5T (in vivo). with water suppression. 51 M s/p surgery and XRT for anasplastic astrocytoma, now with new area of enhancement. MRS: reduced NAA, increased Cho c/w normal. Dx: tumor recurrence.

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MR Spectroscopy

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  1. neurons energy membranes neurotransmitters glia Lipids/lactate MR Spectroscopy 1.5T (in vivo) with water suppression

  2. 51 M s/p surgery and XRT for anasplastic astrocytoma, now with new area of enhancement MRS: reduced NAA, increased Cho c/w normal. Dx: tumor recurrence

  3. 1H Volumetric spiral MRSI Increased Coverage 1.5 T, 7 yo male, TE=144ms, 1 cc voxels, 15 min acq. NAA Cre Cho water

  4. High Resolution Spiral PRESS at 3T Increased Resolution Central slice Spiral PRESS CSI, TR/TE=2000/144ms, 5” surface coil, 32x32x8 matrix, 20x20x10 cm FOV, 0.5 cc voxels, 6 min 40 s acq time

  5. Spiral CT-PRESS at 3T Increased Information Content

  6. Some Current Projects • MRSI-guided biologically conformal radiation therapy • Pediatric brain development • Neurodegenerative disorders • Tumor imaging (brain, breast, prostate) • Hyperpolarized 13C MRSI of metabolic pathways

  7. MRSI of Hyperpolarized 13C Irradiate here to saturate e- spins Polarizing field Maximum effect: Polarizer T Potential gain vs 13C imaging at 1.5T, 310 K is about 400,000 (Gain versus natural abundance study is even higher)

  8. Metabolic Pathways Example Target: Pyruvate Alanine Pyruvate Lactate

  9. Spielman and Co. Smiling on the inside Uses Crest for whiter teeth

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