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TSS

1*. 1*. 1*. 3. 3. 3. 15. 15. 15. 1*. 1*. 1*. 3. 3. 3. 15. 15. 15. 4-2. 4-2. 5. 5. 4. 5. 4. 4. 12. 12. 12. 12. 12. 12. 12. 12. 12. 12. TSS. DNA of Ct-OATP1B3. 5’. 3’. Transcription. Alternative Splicing. Start Codon. Stop Codon. Start Codon. Stop Codon.

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TSS

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  1. 1* 1* 1* 3 3 3 15 15 15 1* 1* 1* 3 3 3 15 15 15 4-2 4-2 5 5 4 5 4 4 12 12 12 12 12 12 12 12 12 12 TSS DNA of Ct-OATP1B3 5’ 3’ Transcription Alternative Splicing Start Codon Stop Codon Start Codon Stop Codon mRNA of Ct-OATP1B3 Translation Translation Mature Protein of Ct-OATP1B3 (674 amino acid) Immature Protein (91 amino acid) Supplemental Figure 1. Alternative splicing of Ct-OATP1B3. Exons of Ct-OATP1B3 are indicated by open boxes. TSS, transcription start site. The mature Ct-OATP1B3 is a 674-amino acid polypeptide, while another variant possesses the terminal codon in the exon 4-2, producing immature 91-amino acid polypeptide.

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