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1*. 1*. 1*. 3. 3. 3. 15. 15. 15. 1*. 1*. 1*. 3. 3. 3. 15. 15. 15. 4-2. 4-2. 5. 5. 4. 5. 4. 4. 12. 12. 12. 12. 12. 12. 12. 12. 12. 12. TSS. DNA of Ct-OATP1B3. 5’. 3’. Transcription. Alternative Splicing. Start Codon. Stop Codon. Start Codon. Stop Codon.

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Tss

1*

1*

1*

3

3

3

15

15

15

1*

1*

1*

3

3

3

15

15

15

4-2

4-2

5

5

4

5

4

4

12

12

12

12

12

12

12

12

12

12

TSS

DNA of Ct-OATP1B3

5’

3’

Transcription

Alternative Splicing

Start Codon

Stop Codon

Start Codon

Stop Codon

mRNA of Ct-OATP1B3

Translation

Translation

Mature Protein of Ct-OATP1B3

(674 amino acid)

Immature Protein

(91 amino acid)

Supplemental Figure 1. Alternative splicing of Ct-OATP1B3.

Exons of Ct-OATP1B3 are indicated by open boxes. TSS, transcription start site. The mature Ct-OATP1B3 is a 674-amino acid polypeptide, while another variant possesses the terminal codon in the exon 4-2, producing immature 91-amino acid polypeptide.


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