Effects of microgravity and space flight on macrophages
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Effects of Microgravity and Space Flight on Macrophages PowerPoint PPT Presentation


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Effects of Microgravity and Space Flight on Macrophages. Stephen Keith Chapes Division of Biology, Kansas State University. Macrophages Respond to Microgravity in Seconds. Bone Marrow Macrophage Growth is Enhanced During Space Flight.

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Effects of Microgravity and Space Flight on Macrophages

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Effects of microgravity and space flight on macrophages

Effects of Microgravity and Space Flight on Macrophages

Stephen Keith Chapes

Division of Biology,

Kansas State University


Macrophages respond to microgravity in seconds

Macrophages Respond to Microgravity in Seconds


Bone marrow macrophage growth is enhanced during space flight

Bone Marrow Macrophage Growth is Enhanced During Space Flight


Bone marrow macrophage differentiation is inhibited during space flight

Bone Marrow Macrophage Differentiation is Inhibited During Space Flight


Space flight enhances macrophage cytokine secretion

Space Flight Enhances Macrophage Cytokine Secretion


B6mp102 macrophage cells growing on cytodex beads

B6MP102 Macrophage Cells Growing on Cytodex Beads


Cartoon of the bioprocessing units used to assess macrophage cytokine secretion

Cartoon of the Bioprocessing Units Used to Assess Macrophage Cytokine Secretion


Conclusions

Conclusions

  • Macrophages respond to microgravity within 8 seconds.

  • Space flight makes bone marrow cells proliferate faster but it slows the rate at which bone marrow cells differentiate into macrophages.

  • Space flight increases the concentration of cytokines the macrophage cell line, B6MP102, secretes.

  • THESE DATA SUGGEST THAT MACROPHAGES ARE AFFECTED BY MICROGRAVITY AND SPACE FLIGHT.


References

References

  • Chapes, S.K., E.S. Didier and W.A.F. Tompkins. 1988. Macrophage cell line B6MP102 resembles peritoneal macrophages in tumor cell recognition and killing.J. Leukoc. Biol. 43:28‑35.

  • Chapes, S.K., D.R. Morrison, J.A. Guikema, M.L. Lewis and B.S. Spooner. 1992. Cytokine secretion by immune cells in space. J. Leukoc. Biol. 52:104-110.

  • Armstrong, J.W., R.A. Gerren and S.K. Chapes. 1995. The effect of space and parabolic flight on macrophage haematopoiesis and function. Exp. Cell Res. 216:160-168.


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