effects of microgravity and space flight on macrophages
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Effects of Microgravity and Space Flight on Macrophages. Stephen Keith Chapes Division of Biology, Kansas State University. Macrophages Respond to Microgravity in Seconds. Bone Marrow Macrophage Growth is Enhanced During Space Flight.

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effects of microgravity and space flight on macrophages
Effects of Microgravity and Space Flight on Macrophages

Stephen Keith Chapes

Division of Biology,

Kansas State University

conclusions
Conclusions
  • Macrophages respond to microgravity within 8 seconds.
  • Space flight makes bone marrow cells proliferate faster but it slows the rate at which bone marrow cells differentiate into macrophages.
  • Space flight increases the concentration of cytokines the macrophage cell line, B6MP102, secretes.
  • THESE DATA SUGGEST THAT MACROPHAGES ARE AFFECTED BY MICROGRAVITY AND SPACE FLIGHT.
references
References
  • Chapes, S.K., E.S. Didier and W.A.F. Tompkins. 1988. Macrophage cell line B6MP102 resembles peritoneal macrophages in tumor cell recognition and killing.J. Leukoc. Biol. 43:28‑35.
  • Chapes, S.K., D.R. Morrison, J.A. Guikema, M.L. Lewis and B.S. Spooner. 1992. Cytokine secretion by immune cells in space. J. Leukoc. Biol. 52:104-110.
  • Armstrong, J.W., R.A. Gerren and S.K. Chapes. 1995. The effect of space and parabolic flight on macrophage haematopoiesis and function. Exp. Cell Res. 216:160-168.
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