Papulosquamous diseases. Psoriasis . Psoriasis is a noncontagious skin disorder that most commonly appears as inflamed, edematous skin lesions covered with a silvery white scale. The most common type of psoriasis is plaque psoriasis . Causes .
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Psoriasis is a noncontagious skin disorder that most commonly appears as inflamed, edematous skin lesions covered with a silvery white scale. The most common type of psoriasis is plaque psoriasis
Many drugs that affect the rate of production of skin cells are used in psoriasis therapy alone or in combination with light therapy, stress reduction, and climatotherapy.
Adjuncts to treatment include sunshine, moisturizers, and salicylic acid as a scale-removing agent.
Generally, these therapies are used for patients with less than 20% of body surface area involved, unless the lesions are physically, socially, or economically disabling.
Vitamin D3 analogue
Treatments for more general or advanced
psoriasis include UV-A light, psoralen plus UV-A
light (PUVA), retinoid eg acitretin, methotrexate
(particularly for arthritis), cyclosporine.
The recognition of the central role of T cells and tumour necrosis factor (TNF)-α in the pathogenesis of psoriasis led to the development of new biologic treatments.
Currently, three biologic TNF-α inhibitors:
and two T-cell agents
It is recommend that these biologic agents
are used as a second-line therapy for
patients with moderate-to-severe psoriasis
1- failed to respond to conventional nonbiologic agents,
2- Have become intolerant to conventional
systemic therapy, and/or cannot receive conventional systemic therapy because of an
increased risk of developing clinically
relevant drug-related toxicity.
3- cannot receive conventional systemic therapy because of an increased risk of developing clinically relevant drug-related toxicity.
Generally, the disease resolves within 12 weeks
Lichen planus (LP) is a pruritic, papular eruption characterized by its violaceous color; polygonal shape; and, sometimes, fine scale. It is most commonly found on the flexor surfaces of the upper extremities, on the genitalia, and on the mucous membranes
Graft Versus Host DiseaseLichen NitidusLichen Simplex ChronicusPityriasis RoseaPsoriasis, GuttatePsoriasis, PlaqueSyphilisTinea Corporis
LP is a self-limited disease that usually resolves within 8-12 months. Mild cases can be treated with fluorinated topical steroids. More severe cases, especially those with scalp, nail, and mucous membrane involvement, may need more intensive therapy
The first-line treatments of cutaneous LP are topical steroids, particularly class I or II ointments. A second choice would be systemic steroids for symptom control and possibly more rapid resolution
Oral acitretin has been shown to be effective in published studies
Patients with widespread LP may respond to narrow-band or broadband UV-B therapy. Psoralen with UV-A (PUVA) therapy for 8 weeks has been reported to be effective.