summary of metabolism
Download
Skip this Video
Download Presentation
Summary of Metabolism

Loading in 2 Seconds...

play fullscreen
1 / 20

Summary of Metabolism - PowerPoint PPT Presentation


  • 92 Views
  • Uploaded on

Summary of Metabolism. Basic Strategies of Catabolic Metabolism. Generate ATP Generate reducing power Generate building blocks for biosynthesis. ATP. Universal currency of energy High phosphoryl-transfer potential

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about ' Summary of Metabolism' - justin


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
basic strategies of catabolic metabolism
Basic Strategies of Catabolic Metabolism
  • Generate ATP
  • Generate reducing power
  • Generate building blocks for biosynthesis
slide3
ATP
  • Universal currency of energy
  • High phosphoryl-transfer potential
  • ATP hydrolysis drives reactions by changing the equilibrium of coupled reactions by a factor of 108
  • Generated from the oxidation of fuel molecules
slide4

Reducing Power

  • Oxidation of fuel molecules generates NADH for mitochondrial ETC
  • NADPH is generated for reducing power for biosynthetic processes
  • Pentose phosphate pathway is the major source of NADPH
slide5

Biomolecules

  • Large number of diverse macromolecules are synthesized from a small number of building blocks.
  • Carbon skeletons from generated from the oxidation of macromolecules provide the building blocks for biosynthetic pathways.
  • Central metabolic pathways have anabolic as well as catabolic roles.
slide7

Relationships between catabolic and anabolic processes

  • The pathway leading to the biosynthesis of a compound are distinct from the pathway leading to its breakdown
  • This separation ensure that the processes are thermodynamically favorable in both directions
  • Allows for reciprocal regulation
slide9

Themes in Metabolic Regulation

  • Allosteric regulation
  • Covalent modification
  • Control of enzyme levels
  • Compartmentalization
  • Metabolic specialization of organs
slide10

Allosteric regulation

  • Typically associated with enzymes that catalyze irreversible reactions
  • Allosteric regulators can cause feed back or feedforward regualtion
  • Allosteric regulators are often related to the energy state of the cell
  • This type of regulation allows for immediate response to changes in metabolic flux (milliseconds to seconds)
  • Functions at local level
slide11

Covalent Modification

  • Covalent modification of last step in signal transduction pathway
  • Allows pathway to be rapidly up or down regulated by small amounts of triggering signal (HORMONES)
  • Last longer than do allosteric regulation (seconds to minutes)
  • Functions at whole body level
slide12

Enzyme Levels

  • Amount of enzyme determines rates of activity
  • Regulation occurs at the level of gene expression
  • Transcription, translation
  • mRNA turnover, protein turnover
  • Can also occur in response to hormones
  • Longer term type of regulation
slide13

Compartmentalization

  • One way to allow reciprocal regulation of catabolic and anabolic processes
slide14

Specialization of Organs

  • Regulation in higher eukaryotes
  • Organs have different metabolic roles i.e. Liver = gluconeogenesis, Muscle = glycolysis
  • Metabolic specialization is the result of differential gene expression
slide15

Lots ATP

G-6-P

Low ATP

Need skeltons

starvation
Starvation
  • Fuels change from glucose to fatty acids to ketone bodies
ad