Towards measles elimination in the western pacific region progress priorities
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Towards Measles Elimination in the Western Pacific Region Progress & Priorities. Global Measles and Rubella Management Meeting Geneva, 15-17 March 2011. Dr. David Sniadack and Dr. Wang Xiaojun Western Pacific Regional Office, WHO. Presentation Outline. Progress towards measles elimination

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Towards Measles Elimination in the Western Pacific Region Progress & Priorities

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Towards measles elimination in the western pacific region progress priorities

Towards Measles Elimination in the Western Pacific RegionProgress & Priorities

Global Measles and Rubella Management Meeting

Geneva, 15-17 March 2011

Dr. David Sniadack and Dr. Wang Xiaojun

Western Pacific Regional Office, WHO


Presentation outline

Presentation Outline

  • Progress towards measles elimination

  • Updates on rubella control

  • Priority activities in 2011-2012

  • Unmet funding needs


Regional committee resolution 2010 wpr rc61 r7

Urged member states

to commit the human and financial resources

to develop and implement work plans

to regularly report surveillance data to WPRO

to establish independent national verification process following the establishment of standardized regional verification mechanisms by WPRO

to accelerate control of rubella and the prevention of congenital rubella syndrome

Requested the RD

to establish regional verification mechanism

to strengthen technical cooperation with Member States to achieve regional immunization goals

to seek additional resources to achieve regional goals utilizing frequent ICC meetings and other mechanisms

to report progress periodically to the Regional committee

Regional Committee Resolution, 2010 WPR/RC61.R7

Reaffirmed the 2012 measles elimination goal


Towards measles elimination in the western pacific region progress priorities

Reported Measles Cases and MCV1 Coverage

Western Pacific Region 1980 – 2010

Source: WPRO surveillance database

WHO/UNICEF JRFs ,1980-2010


Towards measles elimination in the western pacific region progress priorities

Measles Incidence*Western Pacific Region 2010

* per million population

LEGEND

< 1.0 (22)

1.0 – 9.9 (6)

10.0 – 49.9 (5)

50.0 – 99.9 (2)

Data pending (1)

Source: WPRO surveillance database, 2010


Initiatives to improve routine measles coverage western pacific region 2010 2011

Initiatives to Improve Routine Measles Coverage,Western Pacific Region, 2010-2011

  • District approach: tackling low performing districts

    • Region: Capacity building through an inter-country workshop

    • China: Yellow-card warning mechanism (Guangxi, Guizhou)

  • Service delivery: responding to under-served populations

    • LAO PDR: planned increase in frequency of outreach services (4 to 6 times)

    • Philippines: Reaching Every Barangay strategy (REB) and urban poor project

    • Cambodia: Reaching Every Community Strategy (REC)

A chain is only as strong as its weakest link


Towards measles elimination in the western pacific region progress priorities

Measles SIAs in 2010-2011

Western Pacific Region

SIA in China

5 provinces:8m-14y

3 provinces: 8m-6y

23 provinces: 8m-4y

CHN

102.3 million

LAO (9-59m)

3.0 million

PHL (9-95m)

18 million

LEGEND

CAM (9-59m)

1.5 million

2010 (CHN, VTN, PNG, TUV, FSM*)

VTN (9-71m)

7.0 million

FSM (12m-83m,Chuuk)

6762

2011 (CAM, PHL, LAO)

PNG (6-35m)

0.5 million

TUV (12-71m)

1095

2010

2009

Measles Incidence

10.0 – 49.9 (4)

50.0 – 99.9 (2)


Towards measles elimination in the western pacific region progress priorities

Completeness and Timeliness of Country Reporting to WPRO

Western Pacific Region 2007-2010

  • Source: WPR surveillance database


Towards measles elimination in the western pacific region progress priorities

Indicators of Progress Towards Measles Elimination

Western Pacific Region 2007-2010

Source: WPRO surveillance database


Towards measles elimination in the western pacific region progress priorities

Measles and Rubella Lab Network

+331 prefectural labs

382 laboratories

1 GSL

3 RRLs

16 National (13 fully functional)

31 provincial

+ 331 prefectural


Towards measles elimination in the western pacific region progress priorities

LEGEND

At/near (25)

Likely (6)

Hopefully (6)

Probability of Measles Elimination by country, Western Pacific Region

88.4% of

the regional

population

4.1% of the regional population

7.5% of the regional population


Towards measles elimination in the western pacific region progress priorities

Measles Cases by Month

Viet Nam 2008– 2010

Measles Cases by Age

Viet Nam Oct 2008 – 2010

Source: Surveillance data


Towards measles elimination in the western pacific region progress priorities

Laboratory Confirmed and Epi-Linked Measles Cases, by Month, Viet Nam 2010 – 2011*

Measles Cases, by Province

Viet Nam 2010-11*

December 2010

January 2011

Dec 2011– Jan 2011

Jan-Nov 2010

* Data from surveillance reports through March 2011


Towards measles elimination in the western pacific region progress priorities

Confirmed Measles Cases, by Week of Rash Onset,

2009-January 2011

Philippines 2010

1 dot = 1 case

Lab Confirmed and Epi-linked Measles Cases,

by Age, 2010


Towards measles elimination in the western pacific region progress priorities

< 1

1 – 1.9

≥ 2

Lab-Confirmed Measles Cases, by Age Group and Vaccination Status, Cambodia 2010

Laboratory Confirmed Measles Cases and Discarded Rates, Cambodia 2010

1 dot = 1 lab case

Discarded rate (per 100,000)


Rubella control in wpr

Rubella Control in WPR

Regional Plan for Control of Rubella and Prevention of Congenital

Rubella Syndrome in the Western Pacific Region, 2010-2015

Goal: To achieve and maintain control of rubella and prevention of CRS in the WPR

  • Rubella: ≤ 10 / 1 million population, excluding imported cases

  • CRS: ≤ 10 / 1 million Live births, excluding imported cases

July 2010

Nov 2010


Towards measles elimination in the western pacific region progress priorities

WPR: 41 per million population

Rubella Incidence

Western Pacific Region 2009

LEGEND (per million population

< 1.0 (21)

1.0 – 9.9 (8)

10.0 – 19.9 (3)

20.0-99.9 (4)

Data source: JRFs

History of RCV Use in WPR

Protecting F & M ≥ 20 yrs (16)

Protecting F ≥20 yrs (5)

CAM, LAO, VTN

Protecting F & M ≥ 15 yrs (4)

Recent introduction of RCV (5)

RCV to be introduced (6)

PNG, SOL, VAN


Rubella cases by sex and age group 2008 2010

Rubella Cases by Sex and Age Group2008-2010

Viet Nam

Females: 60% CBA

Philippines

89% <20y

Data source: WPRO surveillance and laboratory database


Priority activities of measles elimination western pacific region 2011 2012

Priority Activities of Measles Elimination Western Pacific Region, 2011-2012

Funding not secured

Closing immunity gaps, focusing on priority countries

  • Conducting quality SIAs, incorporating MR when feasible

    • 2011: CAM (Feb-Mar, MV, ? Oct), PHL (Apr, MR), LAO (Nov, MR)

    • 2012: PNG and several Pacific island countries

  • Improving routine MCV1 and MCV2 coverage

    • Introduction of MCV2 (CAM > 80% since 2008)

    • Exploring practical approaches to identifying under-served population groups/communities and improving their access to immunization services

      • Link to needed solution to address quality gaps in previous SIAs (vaccination of children 5-14 years old in CAM)

  • Identify and implement appropriate approach to and strategies for immunizing adults

    • Key constraints: funding, vaccine production capacity (MV or MR)

  • Epidemiologic analysis of adult measles cases in Beijing, China in collaboration with US CDC and WHO


  • Towards measles elimination in the western pacific region progress priorities

    Priority Activities of Measles Elimination Western Pacific Region, 2011-2012

    Continue to improve surveillance, maintain accredited lab network, and provide more support to priority counties

    • Regional Level

      • Publish Measles and Rubella Bulletin monthly (planned in April 2011)

      • Frequent data analysis of countries

      • Update/revise field measles guidelines, incorporating rubella

      • Accreditation of all RRLs and NMLs in2011

    • Country level

      • Capacity building at country level: surveillance workshops

        • CAM, LAO, PNG, VTN

      • Country visits, followed by extensive follow-up actions


    Towards measles elimination in the western pacific region progress priorities

    Priority Activities of Measles Elimination Western Pacific Region, 2011-2012

    Initiate preparation for verification of measles elimination

    • Establish regional verification committee for measles elimination

    • Develop guidelines on verification of measles elimination for the region

    • Organize 1st regional verification commission meeting (September 2011)

    • Assist countries in initiating preparation upon country requests


    Towards measles elimination in the western pacific region progress priorities

    Priority Activities of accelerating Rubella Control & CRS Prevention, Western Pacific Region, 2011-2012

    • Encourage introduction of RCV in Member States

      • With > 80% MCV coverage: CAM (GAVI support), VTN

      • With a need for frequent SIAs: LAO, PNG, SOL, VAN

    • Establish CRS sentinel surveillance (CHN, VTN)

    • Studies on disease burden of CRS (LAO, PHL, VTN)


    Unmet funding need in priority countries western pacific region 2011

    Unmet Funding Need in Priority Countries*Western Pacific Region, 2011

    * Priority countries/areas for funding support: CHN, CAM, LAO, MOG, PHL, PNG, VTN, PICs


    Thank you

    Thank You


    Additional slides

    Additional slides


    Towards measles elimination in the western pacific region progress priorities

    Korea

    B3 from Libya

    Mongolia

    H1, 1

    Japan

    D9 from Thailand, B3 from France

    Hong Kong

    D9 from Philippines, B3 from South Africa

    VietNam

    Macao

    H1, 2 D9, 2

    Lao PDR

    Philippines

    Singapore

    Cambodia

    H1 from Vietnam

    Malaysia

    Australia

    New Zealand

    Genotypic distribution of Measles virus in WPR 2009-2010


    Reported mcv1 and mcv2 coverage by country area western pacific region 2009

    Reported MCV1 and MCV2 Coverage by Country/Area, Western Pacific Region 2009

    16

    Non-Pacific Island Countries

    20

    Pacific Island Countries

    * For five countries with 2009 data not available, historic coverage data were used, including AMS (2008), WAF (2007), GUM (MCV1 in 2005, MCV2 in 2008)

    Source: WHO/UNICEF JRFs, 2009


    Towards measles elimination in the western pacific region progress priorities

    Reported Measles Cases, China 2009 – 2011*

    Measles SIA

    Decrease from previous year

    65%

    44%

    44%

    *Surveillance report through February 2011


    Towards measles elimination in the western pacific region progress priorities

    Trends in Age Distribution and Geographic Spread of Measles

    Viet Nam October 2008-2010

    Jan-Jun09

    Jul-Dec09

    Jan-Dec10

    Oct-Dec08


    Towards measles elimination in the western pacific region progress priorities

    Confirmed Measles Cases, by Month of Rash Onset,

    Philippines 2003 – January 2011

    D3

    D9

    D9. G3


    Towards measles elimination in the western pacific region progress priorities

    Laboratory Confirmed Measles Cases

    Philippines 2010 - January 2011

    Oct 2010

    Nov2010

    Dec 2010

    Jan2011


    Towards measles elimination in the western pacific region progress priorities

    Measles Cases, by Month of Rash Onset and Method of Confirmation, Cambodia 2003 – 2011*

    Clinically Confirmed

    Lab confirmed

    * Data reported as of March 2011


    Towards measles elimination in the western pacific region progress priorities

    Reported Rubella Cases and RCV CoverageWestern Pacific Region 1993-2009

    Incidence (2009): 41 per million population

    Reported coverage

    Coverage estimate with China data

    With disease data from China

    Data source: WHO/UNICEF Joint Reporting Forms, 1993-2009 and measles rubella surveillance data


    Challenges of measles elimination western pacific region

    Challenges of Measles Elimination Western Pacific Region

    • High measles incidence in several countries

    • Evolving epidemiology

      • Shifting to infants and adults

      • Increased risk of measles transmission in densely populated urban areas

    • Importation and exportation

      • Importation: to Australia and New Zealand from several countries and Regions

      • Exportation: from Philippines to Australia, Canada, Japan, New Zealand and U.S.


    Towards measles elimination in the western pacific region progress priorities

    Challenges of Measles Elimination - Immunity Gaps

    • Difficulty in ‘eliminating’ immunity gaps

      • Inadequate monitoring to identify low coverage areas/ populations

      • Inadequate systems and/or resources to increase responsiveness to under-served populations

      • Identifying and addressing quality gaps in previous SIAs

      • Identifying and implementing appropriate strategies to address measles in infants and adults


    Challenges of measles elimination surveillance

    Challenges of Measles Elimination - Surveillance

    • Low sensitivity of surveillance at sub-national levels

    • Difficulty in timely obtaining accurate epidemiologic data

      • Delayed and incomplete case investigation data

      • Discrepancies between lab reports and national reports

    • Large proportion of clinically confirmed cases in some countries

    • Inadequate attention to collecting specimens for virus detection


    Challenges of measles elimination

    Challenges of Measles Elimination

    • Funding gaps: Increasing needs and decreasing resources/sources

    • Competing priorities and stretched HRs

    • High level and broad political commitment

      • Interest and confidence in measles elimination


    Reasons for missed opportunities to rubella control

    Reasons for Missed Opportunities to Rubella Control

    • Lack of evidence

      • Although rubella case are identified in greater numbers, CRS is under-reported and under-recognized in most developing countries in the region, resulting in less priority

    • Lack of motivation

      • Perception that control of rubella and prevention of CRS is an additional task: health officials are not motivated especially under pressure of eliminating measles by 2012


    Towards measles elimination in the western pacific region progress priorities

    Confirmed Measles Cases, by Week of Rash Onset,

    2009-January 2011


    Rubella cases by sex and age group western pacific region 2008 2010

    Rubella Cases by Sex and Age GroupWestern Pacific Region 2008-2010

    Data source: WPRO surveillance and laboratory database


    Towards measles elimination in the western pacific region progress priorities

    Laboratory Confirmed Measles Cases, by Age, Cambodia 2010

    N = 457


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