1 / 16

OBAT SISTEM SARAF OTONOM

OBAT SISTEM SARAF OTONOM. Disampaikan Oleh : Ida Mukhlisa , S.Farm,Apt. Sistem Saraf Otonom. Secara anatomi SSO dibagi menjadi 2 bagian besar : Parasimpatis ( Kraniosakral )

jenette-bailey
Download Presentation

OBAT SISTEM SARAF OTONOM

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. OBAT SISTEM SARAF OTONOM DisampaikanOleh : Ida Mukhlisa, S.Farm,Apt

  2. SistemSarafOtonom Secaraanatomi SSO dibagimenjadi 2 bagianbesar : Parasimpatis (Kraniosakral) Secaraanatomi, serabutparasimpatisberadadikraniosakralpada spinal cord, mempunyaiserabutpreganglion yang panjangdanserabutpostganglion yang pendek. Ganglion dekatatauadapadajaringan target. 2. Simpatis (Thorakolumbar) Secaraanatomi, serabutsimpatisberadadibagianthorakolumbar spinal cord, memilikiserabutpreganglionpendekdengansinapsdalam ganglia yang membentukrantai – batangsimpatik. Sebagianbesarjarignandiinervasiolehsarafparasimpatikdansimpatik, tetapiadabeberapapengecualian.

  3. Flow Chart Sistem Saraf

  4. Reseptor Neurotransmitter SSO

  5. Jenis Reseptor Otonom

  6. Gambar 1 : Classification of cholinergic and adrenergic receptor types and subtypes.

  7. Alpha Receptor

  8. AktivitasSarafOtonomterhadapBeberapaSistem Organ

  9. 1. AgonisAdrenergikKerjaLangsung Selectivitasrelatifagonisadrenoreseptor

  10. AgonisAdrenergik

  11. 3. AgonisAdrenergikKerjaCampuran Ephedrine Alkaloid yang berasaldaritanaman, menstimulasisecaralangsungreseptor dan  sertamenstimulasipelepasannorepinephrine. Diabsorbsisecaraoral,diekskresikandalambentuk yang tidakdiubahmelaluiurin. Meningkatkanteanandarahmelaluistimulasi  dan . Merupakan bronchodilator. Ephedrine menghasilkanstimulasiringanterhadap SSP  siaga  rasa lelahdanngantuk. Digunakansebagaidekongestanjuga. Toleransidantakhfilaksisdiketahuidenganbaik. Pseudoephedrine Digunakanpadaalergi rhinitis dan flu biasa. Padadosistinggimenyebabkan TD  danmenstimulasijantung Diberikansecara oral. Jikadicampurdapatmenstimulasi SSP.

  12. AntagonisAdrenergik They are subclassified on the basis of  selectivity, partial agonist activity, local anesthetic action and lipid solubility. Classification : Non Selective  blockers: e.g. Propranolol, Satalol, PindololTimolol and Nadolol. Cardioselective  blockers: e.g. Atenolol, Acebutolol, Metoprolol, Esmolol. Drugs whick block both  and  adrenergic receptors e.g. Labetalol. Non selective  blockers with vasodilator action as carvedilol. N.B :Acebutolol, atenolol and nadolol are less lipid soluble and probably enter the CNS to a lesser extent.

  13. AntagonisAdrenergik

  14. SelektivitasRelatifAntagonisuntukAdrenoreseptor

  15. ReseptorKolinergik Reseptorkolinergikterbagi 2 type : ReseptorAChNikotinik Reseptor Ach Muskarinik Banyakdijumpaisistemsarafdiperifermaupundipusat. Keduanyaberbedadalamhaltransduksisinyalnya.

More Related