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GENESDEV/2009/125252_Wu_ Supplemental Fig1. 1.5. 1. Heme Level. *. *. 0.5. 0. SA (mM): 0 1 2.5 5 10. GENESDEV/2009/125252_Wu_ Supplemental Fig2. SiRev-erb  - +. Rev-erb . GSK3 . GENESDEV/2009/125252_Wu_ Supplemental Fig3. A. 3.

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  1. GENESDEV/2009/125252_Wu_ Supplemental Fig1 1.5 1 Heme Level * * 0.5 0 SA (mM): 0 1 2.5 5 10

  2. GENESDEV/2009/125252_Wu_ Supplemental Fig2 SiRev-erb - + Rev-erb GSK3

  3. GENESDEV/2009/125252_Wu_ Supplemental Fig3 A 3 PCDNA3.1 Rev-eb * 2 Fold Repression 1 0 Reporter: hPGC1-luc Rev-erb: B 2 PCDNA3.1 Rev-eb * Fold Repression 1 0 Rev-erb hPGC1-luc: WT RREpm RREdm RREp/dm

  4. GENESDEV/2009/125252_Wu_ Supplemental Fig4 2.0 SiControl SiRev-eb 1.5 1.0 ChIP enrichment 0.5 0 Ab: HDAC3 Hsp90

  5. GENESDEV/2009/125252_Wu_ Supplemental Fig5 A shRNA - + HDAC3 b-actin B siRNA - + NCoR b-actin

  6. GENESDEV/2009/125252_Wu_ Supplemental Fig6 A 3 * 2 PGC1 mRNA 1 0 Succinylacetone(mM):0 1 2.5 5 B 5 mRNA level DMSO 4 SA+DMSO SA+Heme 3 * * 2 1 0 PGC1 Bmal1 C Dex 1uM ETOH + + + + + Heme PGC1a Rev-erba b-actin

  7. GENESDEV/2009/125252_Wu_ Supplemental Fig7 Control-3T3 Cells 1.5 1.0 Respiration-driven Oxygen Consumption Rate 0.5 0 DMSO Hemin (2.5M)

  8. GENESDEV/2009/125252_Wu_ Supplemental Fig8 1.5 Rev-erb mRNA level 1.0 0.5 0 Day1 Day3 Day5

  9. GENESDEV/2009/125252_Wu_ Supplemental Fig9 A 12 10 8 * S (%) 6 * 4 2 0 Control-3T3 REV-3T31 REV-3T32 B 100 80 * * 60 G1(%) 40 20 0 Control-3T3 REV-3T31 REV-3T32

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