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Center for Advancing Longitudinal Drug Abuse Research (CALDAR)

Integrated Substance Abuse Programs. Center for Advancing Longitudinal Drug Abuse Research (CALDAR). Funded by The National Institute on Drug Abuse September 2005 - August 2010. Center Overview. Purpose CALDAR Overarching Theme Conceptual Framework Specific aims Structure

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Center for Advancing Longitudinal Drug Abuse Research (CALDAR)

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  1. Integrated Substance Abuse Programs Center for Advancing Longitudinal Drug Abuse Research (CALDAR) Funded by The National Institute on Drug Abuse September 2005 - August 2010

  2. Center Overview Purpose • CALDAR Overarching Theme • Conceptual Framework • Specific aims Structure • Organizational Chart • Three Cores • Projects Products Year 1 Cross-project analyses Other activities

  3. CALDAR Overarching Theme Development and application of rigorous scientific approaches for advancing longitudinal research on drug abuse and its interplay with HIV infection, drug treatment, and other service systems.

  4. Why Is This Theme Important? • Disconnect in • Chronicity of the disorder and short-term/discrete observation/approach • Controlled studies and real world applications • Methodological challenges • Non/experimental observation • Multiple and interactive causes and effects • Data quality • Human subject issues • Longitudinal/multilevel statistical models

  5. Conceptual Framework

  6. Examples of Key Substantive Issues • How chronic drug use patterns evolve and interact with service systems? • Long-term disease management: • How much treatment is needed for individuals whose problems are chronic? • What/how treatment should be if the previous one was unsuccessful? • Is there a threshold required for positive effects of treatment to emerge? • What effects are observable across multiple treatment episodes and different levels of care? • Health disparity

  7. Specific Aims • Increase knowledge of longitudinal patterns of drug addiction and their interplay with HIV infection, drug treatment, and other service systems. • Enhance the quality and efficiency of research conducted by Center-supported projects by providing centralized support to serve common project functions.

  8. Specific Aims, continued • Provide opportunities for scientific collaboration and cross-project analyses, stimulating conceptual development and integration, and advancing improved research methodologies and statistical approaches. • Enhance the relevance and application of longitudinal research on drug use by facilitating dissemination of integrated project findings to a variety of communities

  9. Organizational Chart

  10. Three Cores • Coordination & Integration (C&I): provides overall leadership for the Center projects and for administration and coordination across Cores • Research Support & Development (RS&D): enhances the conceptualization of and methodological approaches to longitudinal research. • Statistical Support & Data Management (SS&DM): provides support in statistics and data management

  11. Research Development Core • Conceptual development and integration workgroup • Database acquisition workgroup • Regulatory affairs workgroup • Community advisory board

  12. RS&D Workgroups

  13. Statistical Support & Data Management Core • Consulting/training/technical assistance • Data acquisition & management • Analytic strategies • Analytic support to cross-project analyses • Standards for data quality/documentation • Cross-walks for databases

  14. Aims Related to longitudinal analysis…. • Consultation • Education • Analysis • Data accessibility/comparability

  15. Consultation • Answer questions by CALDAR researchers, e.g. • Data acquisition and management of longitudinal data sets • Choice of analytic methods for longitudinal analysis (HLM, mixed models, growth models, GEE, SEM…) • Setting up analyses • Interpretation of results • Compare methods • Create guidelines and examples for analysis • Develop algorithms for power analysis • Web links to other stat resources

  16. Education • Workshops on stat methods & related topics, by CALDAR staff and guest researchers • Workshop on longitudinal applications to be proposed for CPDD • Summer Institute—analysis (2007)

  17. Analysis • Cross-project analyses, e.g. • Long-term drug use and cessation (trajectories) • Drug treatment effects over time • Interplay with criminal justice • Drug users with mental health disorder

  18. Data Accessibility/Comparability • Develop standards for documentation, quality assurance • Develop crosswalks for CALDAR data sets • Enhance ISAP data mgt. capabilities

  19. SSDMC Structure • L. Brecht, Core Director • D. Huang, Core Assoc. Director & Sr. Statistician • To-be-named/hired (partial FTEs): • Sr. statistician • Statistician/data manager • Research & admin assistants • Consultants • Bengt Muthen • Linda Collins • Chi-Ping Chou

  20. 41 Longitudinal Studies • 10 active ISAP/UCLA projects • 8 external collaborators’ active projects • 9 longitudinal studies under review • 18 recently completed projects • 13 archived projects

  21. ISAP/UCLA Active Projects • L. A. County Evaluation System: An Outcomes Reporting Program (LACES) • Evaluation of California Substance Abuse Treatment Facility (SATF) • Substance Abuse and Crime Prevention Act (SACPA) Evaluation • Evaluation of Female Offender Treatment and Employment Program (FOTEP) • Pacific Coast Research Center of the NIDA CJ-DATS • Treatment System Impact and Outcomes of Proposition 36 (TSI) • HBV Prevention for Homeless At-risk for HBV/HCV/HIV • Course of Problems in Adolescent Drug Treatment Intakes • Integrated Drug and Medical Care-Cost and Effectiveness • Motivational Intervention with Drug-using Facial Injury Patient

  22. Center Products • Serve as a national resource on longitudinal drug abuse research • Develop and make widely available training and educational program materials (e.g., workshops, seminars, website) • Four cross-project analyses per year • Two journal special issues • Publications and grant applications

  23. Centralized Support • Common instruments/measures • Administrative records acquisition • Human subjects • Analytic support

  24. Cross-project Analyses • Priority Areas: • Drug use/HIV • Treatment • CJS • Mental health • First year • Subsequent years, prioritized by: • Multiple projects/databases • Multiple observations • Health services

  25. First Year Cross-project Analyses • Nine archived datasets/projects • Natural History Interview and Addiction Severity Index measures • Administrative records • Analyses • Long-term drug use and cessation • Drug treatment effects over time • Interplay with criminal justice • Drug users with mental health disorders or HIV

  26. First year cross-study analyses • Methamphetamine Natural History (Brecht/Anglin) • Multi-site Methamphetamine Follow-up (Marinelli-Casey/Rawson) • 33-year Heroin Follow-up (Hser/Anglin) • 12-year Cocaine Follow-up (Hser/Anglin/Stark/Rawson/Paredes) • Treatment Utilization & Evaluation (Hser/Longshore/Anglin) • Long-term Impact of Drug Treatment on Outcome & Cost (Weisner) • Integrated Drug & Medical Care (Weisner) • Dual Diagnosis (Grella/Anglin/Hser) • Long-term Course of Treatment & Untreated Alcohol Abuse (Moos)

  27. Cross-projects Analyses(challenges) • Comparability across projects • Measures • Assessment time points and periods • Data sources • Analytic strategies for causal inferences

  28. Growth Model with Time-Invariant & Time-Varying Covariates

  29. Drug use Growth Mixture Model

  30. Other activities • Consulting/training/technical assistance • Internal • External, via Website • Educational workshop • CPDD • R13 application • Dissemination • CPDD presentations • Review articles • Other conference presentations

  31. Committees

  32. Center meetings • External • Scientific advisory board • Community advisory board • Internal • Executive committee/project committee • Research core workgroups • Dissemination committee • Training development committee

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