1 / 29

Quiz 3 review | September 25, 2013

Quiz 3 review | September 25, 2013. Quiz 3 Review. Autoimmune diseases Immunodeficiencies Transfusion Transplantation. Quiz 3 Review. Autoimmune diseases. Lupus. Typical patient: young woman with butterfly rash Symptoms unpredictable (relapsing/remitting)

gavivi
Download Presentation

Quiz 3 review | September 25, 2013

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Quiz 3 review | September 25, 2013

  2. Quiz 3 Review • Autoimmune diseases • Immunodeficiencies • Transfusion • Transplantation

  3. Quiz 3 Review • Autoimmune diseases

  4. Lupus • Typical patient: young woman with butterfly rash • Symptoms unpredictable (relapsing/remitting) • Multisystem (skin, kidneys, joints, heart) • Antinuclear antibodies Things You Must Know

  5. Lupus: butterfly rash

  6. Rheumatoid Arthritis • Symmetric, mostly small-joint arthritis • Systemic symptoms (skin, heart, vessels, lungs) • Rheumatoid factor • Cytokines (especially TNF) cause damage Things You Must Know

  7. Rheumatoid arthritis joint deformities

  8. Rheumatoid nodules

  9. Sjögren Syndrome • Inflammatory disease of salivary and lacrimal glands • Dry eyes, dry mouth • T cells react against some Ag (self? viral?) in gland; gland gets destroyed • Increased risk of lymphoma Things You Must Know

  10. Sjögren syndrome: salivary gland enlargement

  11. Scleroderma (Systemic Sclerosis) • Excessive fibrosis throughout body: skin, viscera • Claw hands, mask-like face • Microvascular disease also present • Diffuse and limited types Things You Must Know

  12. Systemic sclerosis: claw hands

  13. Systemic sclerosis: restricted mouth opening

  14. Quiz 3 Review • Autoimmune diseases • Immunodeficiencies

  15. Immune Diseases Outline

  16. Quiz 3 Review • Autoimmune diseases • Immunodeficiencies • Transfusion

  17. What are the products? • Whole blood • Red cells • Platelets • Granulocytes • Cryoprecipitate • Fresh frozen plasma

  18. FORWARD TYPE anti-A antibodies AHG patient red cells (type A) Forward typing is done using both anti-A and anti-B antibodies!

  19. REVERSE TYPE reagent red cells (type B) AHG patient serum (with anti-B Ab) Reverse typing is done using both type A and type B reagent cells!

  20. CROSSMATCH donor red cells AHG patient serum

  21. What can go wrong? • Transfusion reactions • hemolytic • non-hemolytic • Other complications • infections • circulatory overload • iron overload • graft-versus-host disease

  22. Quiz 3 Review • Autoimmune diseases • Immunodeficiencies • Transfusion • Transplantation

  23. Histocompatibility • Histocompatible: antigenically similar to the host • Histoincompatible: antigenically different from the host • MHC antigens are the most important • ABO antigens are also important • Minor histocompatibility antigens are less important

  24. HLA genes are inherited as sets! ♂ ♀ parents a/b c/d four possible haplotype combinations of children a/d b/c a/c b/d

  25. HLA alleles A B C DR DQ DP a 1 7 w3 2 1 1 b 2 8 w2 3 2 2 haplotypes c 3 44 w4 4 1 3 d 11 35 w1 7 3 4 HLA genes are polymorphic!

  26. number of mismatches Class I Class II 100 50 graft survival, % 3 6 12 time after transplant, months

More Related