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输血相关性移植物抗宿主病 (TA-GVHD) PowerPoint PPT Presentation


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辐照血液的临床应用 卫生部血液安全研究重点实验室 创始人、首任主任国家卫生标准委员会血液标准专业委员会 顾问 中国输血协会 顾问 中国输血协会专家委员会 主任委员 浙江省输血协会 理事长 严力行 教授. 输血相关性移植物抗宿主病 (TA-GVHD). 免疫缺损或免疫抑制的患者 不能清除输入血液中具有免疫活性淋巴细胞 在体内植活、增殖 将患者的组织器官识别为非己物质,进行免疫攻击、破坏

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输血相关性移植物抗宿主病 (TA-GVHD)

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Ta gvhd


Ta gvhd

(TA-GVHD)


Ta gvhd

  • 0.010.1

  • 8090


Pt gvhd

PT-GVHD

  • 0.01%0.1%1/8741/71741/16641/3144

  • 0.1%2.0%

  • 15%20%(1995)

  • 0.28%4/1439Transfusion 1998,38:117-1118

  • 2%4/200200013153-155


Ta gvhd

TA-GVHD


Ta gvhd

(1)

(2)5-

(3)

(4)

(5)

(6)

(7)


Ta gvhd

:


Ta gvhd

1

2,/

3


Ta gvhd

T


Ta gvhd

5.4X109L104kgTA-GVHD


Ta gvhd

  • 2.0X109LTA-GVHD


Ta gvhd

TA-GVHD()()


Ta gvhd

HLA

TA-GVHD 1/283501/277001/4750


Cd 8 nk

CD8NK

  • CD+8NK

  • IL-1IL-2TNF


Ta gvhd

  • 10-14d2-30d


Ta gvhd

  • 1-3>90%


Ta gvhd


Ta gvhd

1

2

3


Ta gvhd

DNA12 PCR


Ta gvhd1

TA-GVHD


Ta gvhd

(1)


Ta gvhd

(2)

TA-GVHD


Ta gvhd

TA-GVHD


Ta gvhd2

TA-GVHD

  • DNA


Ta gvhd

  • DNA


Ta gvhd

30-40


Ta gvhd

  • 104kg


Ta gvhd

1

2-3-6

3III


Ta gvhd


Ta gvhd

  • Gy1Gy=100cGy


Ta gvhd


Ta gvhd

  • 137Cs(60Cor

  • 25-30GY60Co 137 Cs

  • 30GY


Ta gvhd

  • (15-25Gy)


Ta gvhd

(T)


Ta gvhd

(3T-TdR)T(LDA)25GyT


Ta gvhd

3


Ta gvhd

TA-GVHD TA-GVHD


Ta gvhd


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