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Temporal Changes in Functional Gene Group Expression Occur Early in Alzheimer`s Disease Progression

Temporal Changes in Functional Gene Group Expression Occur Early in Alzheimer`s Disease Progression. Shahar Barbash And Prof Hermona Soreq. Research question. Disease processes. Early events. Disease progression. Late events. Which events are late and which events are early?.

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Temporal Changes in Functional Gene Group Expression Occur Early in Alzheimer`s Disease Progression

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  1. Temporal Changes in Functional Gene Group Expression Occur Early in Alzheimer`s Disease Progression ShaharBarbashAnd Prof HermonaSoreq

  2. Research question Disease processes Early events Disease progression Late events Which events are late and which events are early? Barbash & Soreq

  3. Research question What would be a relevant disease event - single key transcripts or gene groups? 1 Which events are late and which events are early? 2 Barbash & Soreq

  4. Analyzed Data Sets Hip Incipient, 20<MMSE<25 Moderate, 15<MMSE<20 Severe, MMSE<15 Hip, EC, PVC Barbash & Soreq

  5. Analysis Approach Small number of large changes Large number of small changes Barbash & Soreq

  6. What would be a relevant disease event – single transcripts or gene groups? 1 Barbash & Soreq

  7. What is a Relevant Disease Event? IGD: Inter-group Dissimilarity LCM: Laser-captured Micro- dissection Barbash & Soreq

  8. Cognitive State Identifies Gradual Shifts in: cell type and sub-cellular specific transcripts biological processes Barbash & Soreq

  9. Gene groups reflect hippocampal alterations in AD better than single genes What is a relevant disease event? 1 Change in gene group expression. Which are late events and which are early events? 2 Barbash & Soreq

  10. Different Hippocampcal Processes Show Distinct AD Dynamics Barbash & Soreq

  11. Conclusions • Gene groups reflect hippocampal alterations in AD better than single genes • Some processes are altered early while some are altered late in the disease Barbash & Soreq

  12. Acknowledgments PhD Supervisor: Prof Hermona Soreq Lab members: Dr. David Greenberg Dr. Estelle R. Bennett Keren Ailon Mor Hanan Geula Hanin Nir Waiskopf Lilach Soreq Yael Goll Uriya Bekenstein Nadav Yayon The Eric Roland Center for Neurodegen​erative Diseases‏

  13. End Barbash & Soreq

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  16. Distribution comparisons • Global expression ratio between AD and control. • Down regulated functional group. • Up regulated functional group. • Tightly regulated functional group. Kolmogorov-Smirnov (KS) Barbash & Soreq

  17. Barbash & Soreq

  18. AD involves alterations in gene groupsbut not single genes Barbash & Soreq

  19. Cognitive measure identified gradual shifts in microRNAs population mirRor:Friedman Y et al, Bioinformatics,2010 Barbash & Soreq

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