Anatomy and Physiology

1. Anatomy and Physiology Katie Mackey Period 2 September 5th 2013

2. 1)Define Anatomy and Physiology and describe their subdivisions • Anatomy: This is the study of the structure of the body parts and their relationship to each other. • Cytology: study of the cells • Histology: study of the tissues • Developmental anatomy: study of changes in structure • Embryology: study of the changes up to birth • Pathologic anatomy: study of the changes due to disease and abnormal structures • Radiographic anatomy: study of the body using x-rays • Regional anatomy: study of the structures associated with the hand or neck • Systemic anatomy: study of the body system by each system • Surgical anatomy: study of the structures and landmarks of the body which is useful in surgery • Physiology: This is the study of the functions of the body parts. • Neurophysiology: study of the functional properties of nerve cells • Endocrinology: study of hormones and how they control body functions • Cardiovascular physiology: study of the functions of the heart and blood vessels • Immunology: study of how the body defends itself against disease • Respiratory physiology: study of the functions of the lungs and air passageways • Renal physiology: study of the functions of the kidneys • Exercise physiology: study of the functions of the changes in cells and organs as a result of muscular activity • Pathophysiology: study of the functional changes associated with aging and disease

3. 2) Name Different levels of structural organization that make up the human body and explain their relationship. • Chemical Level • This is the basic level and includes atoms and how they combine to form molecules. The two essential molecules are DNA and glucose. • Cellular Level • Molecules combine to form cells. The three main cells are muscle, nerve and epithelial cells. • Tissue Level • Tissues are groups of cells that work together to perform functions. The four main tissues are connective, nervous, muscle and epithelial. • Organ Level • This level is when tissues join together; two or more tissues joined together form a structure that has a specific function and shape. • System Level • This level consists of two or more organs that work together for one purpose. An example is the digestive system, many organs working together. • Organismal Level • This is all the organs working together to create a living individual.

4. 3)List the 11 organs of the body, identify their components and briefly explain the major functions of each system. • Skeletal System • Components – bones and cartilage • Functions – provides support and structure, also stores calcium and other minerals • Muscular System • Components –skeletal muscle, tendons and ligaments • Functions – provides movement and can help generate heat • Integumentary System • Components – consists of skin, nails, hair, and sweat glands • Functions – provides protection from outside hazards, maintains body heat and provides sensory information • Nervous System • Components – consists of brain, spinal chord, and all the nerves in the body • Functions – interprets sensory information, directs immediate responses and coordinates other organ systems activities • Endocrine System • Components –testes, ovaries, adrenal glands, pituitary glands, pancreas and the thyroid gland • Functions – his adjusts metabolic activity and regulates hormones during development

5. #3 Continued • Circulatory/Cardiovascular System • Components – this consists of the blood, blood vessels and the heart • Functions – distributes blood, water, oxygen, waste products and other nutrients through the body • Lymphatic System • Components – consists of the spleen, thymus, tonsils, and lymph nodes • Functions – helps the body defend itself against disease and infection • Respiratory System • Components – this is the lungs, trachea, larynx, sinuses, bronchi and nasal cavities • Functions - provides the blood stream with oxygen and removes carbon dioxide • Digestive System • Components – tongue, teeth, stomach, small and large intestines, liver, gallbladder, pancreas, esophagus and pharynx • Functions – breaks down the food and absorbs its nutrients • Urinary System • Components – ureters, urethra, kidneys and bladder • Functions – rids the body of waste • Reproductive System • Components – uterus, ovaries, vagina, clitoris, labia, mammary glands, penis, testes, scrotum, and epididymis • Functions – produce sperm and eggs and help the body to carry and nurture a child

6. 4) List the Functional Characteristics necessary to maintain life in humans Movement Responsiveness Digestion Metabolism Excretion Reproduction Growth

7. 5) Define Homeostasis and explain its significance • Homeostasis- This is the tendency of a system to maintain internal stability. • Maintenance of internal environments set limits • This is a dynamic equilibrium not a set rate • Without homeostasis there could be no life because failure of homeostasis leads to disease • This keeps your temperature steady not too high or too low, it keeps the blood flow even, and your heartbeat even, also it keeps the amount of chemicals and nutrients in your body at a correct amount

8. 6) Describe how negative and positive feedback maintain body homeostasis The two balance each other out to maintain homeostasis.

9. 7) Describe the anatomical position Anatomical Position- This is a standard position of the body. It is standing erect, facing directly forward, feet pointed forward and slightly apart, and arms hanging down at the sides with palms facing forward. This position is used as a reference to describe sites or motions of various parts of the body.

10. 8) Use correct anatomical terms to describe body directions, regions and body planes or sections Anterior: In front of, front Posterior: After, behind, following, toward the rear Distal: Away from, farther from the origin Proximal: Near, closer to the origin Dorsal: Near the upper surface, toward the back Ventral: Toward the bottom, toward the belly Superior: Above, over Inferior: Below, under Lateral: Toward the side, away from the mid-line Medial: Toward the mid-line, middle, away from the side Rostral: Toward the front Caudal: Toward the back, toward the tail Cranial: located near the head Frontal or Coronal Plane- divides the anterior and posterior parts of the body Sagittal Plane- divides the right and left sides of the body Transverse plane- divides the superior and inferior parts of the body

11. 9) Locate and name the major body cavities and their subdivisions and list major organs contained within them

12. 10) Name the serous membranes and indicate their common functions • Visceral Pleura • This covers the outside of the lungs • Parietal Pleura • This lines the inside of the lungs • Parietal Peritoneum • This lines the inside of the abdominal cavity • Visceral Peritoneum • This lines the outside of the abdominal cavity • Visceral Pericardium • This lines the outside of the heart • Parietal Pericardium • This lines the inside of the heart

13. 11) Name the nine regions or four quadrants of the abdominopelvic cavity and list the organs they contain. 4 Quadrants • Left upper • Part of stomach, spleen, small and large intestines • Right upper • Liver, gallbladder, part of small and large intestines and stomach • Left lower • Part of large and small intestine • Right lower • Appendix, cecum, small and large intestine

14. #11 Continued 9 Regions • Left Hypochondriac • Spleen and part of stomach • Right Hypochondriac • Liver and gallbladder • Epigastric Region • Liver and part of stomach • Left Lumbar Region • Left kidney, part of small intestine and part of colon • Right illiac • Cecum, right ovary, fallopian tube and appendix • Right lumbar region • Right kidney and part of the colon • Umbillical region • The umbilicus, part of the colon and small intestine • Left illiac • Part of the colon, left ovary, and fallopian tubes • Hypogastric/ Pubic region • The uterus (in females) and bladder

15. 12) Describe major energy forms There are many forms of energy but the two major forms are Kinetic and Potential. Kinetic Energy This is the energy in a moving object or mass. Ex) wind energy that is produced by wind turbines Potential Energy This is the stored energy an object may have. Ex) a ball being held at the top of a hill has potential energy because when the ball is released it will roll down the hill producing kinetic energy

16. 13) Define chemical element and list the four elements that form the bulk of body matter Chemical element- A substance which cannot be broken down or changed by chemical means. Oxygen Hydrogen Carbon Nitrogen Are the four most abundant elements found in the human body.

17. 14) Compare solutions, colloids and suspensions

18. 15) Compare and contrast polar and non-polar compounds.

19. 16) Define three major types of chemical reactions: synthesis, decomposition, and exchange. Comment on the nature of oxidation reduction reactions and their importance. Synthesis- two elements come together to form one compound. Decomposition- one single compound breaks apart into the elements that form it. Exchange- one element in each compound switch to form two new compounds. Oxidation Reduction Reactions is and gain and loss of electrons. Each one counts as half of a reaction.

20. 17) Explain why chemical reactions in the body are often irreversible Chemical Reactions are often irreversible because … • Many chemical reactions that take place in the body are open systems, this means different parts of the reaction can escape. To reverse a chemical reaction it needs to be in a close system. • Also the energy that would fuel the reverse reaction is used up while completing the first reaction.

21. 18) Explain the importance of water and salts to body homeostasis When this balance is maintained this means that the kidneys are functioning properly and removing bodily waste as they should.

22. 19) Define acid, base and explain the concept of pH Acid : • ionic compounds that break apart in water to form hydrogen ions (H+) • Has a pH less than 7 • the more H+ the stronger it is, meaning a lower number on the pH scale • Proton donors because in chemical reactions they give the protons to bases Base : • Ionic compounds that break apart in water to from hydroxide ions (OH-) • Has a pH greater than 7, most bases are called alkaline • Proton acceptors because they receive protons in chemical reactions from acids pH : This is the measure of the concentration of hydrogen ions in a solution. The more hydrogen ions the lower the pH is and the more acidic it is. The lower the concentration of hydrogen ions the higher the pH is and more basic it is.

23. 20) Describe the general mechanism of enzyme activity General Enzyme activity • Enzymes speed up reactions but are very specific so they only work in one reaction. • They can be used multiple times. • Their shape determines their function like in the lock and key analogy. • They only stop working when they are denatured.

24. 21) List the three major regions of a generalized cell and indicate the function of each Nucleus or control center, directs cell activity and is necessary for reproduction. The nucleus contains genetic material (DNA), which carries instructions for synthesis of proteins. Plasma membrane is the selective barrier to the movement of substances into and out of the cell. It is composed of a bi-lipid layer containing proteins. The water-impermeable lipid portion forms the basic membrane structure. The proteins (many of which are glycoproteins) act as enzymes or carriers in membrane transport. Cytoplasm is where most cellular activities occur. This contains the all the organelles.

25. 22) Describe the chemical composition of the plasma membrane and relate it to membrane functions The cell membrane is a phospholipid bilayer. • It consists of hydrophilic polar phosphate heads pointed outward and hydrophobic nonpolar tails (fatty acids) pointed inward. • The membrane can attract water and other polar substances. • With the help of receptors the membrane regulates what goes in and out of the cells. • The Hydrophilic heads also interact with other cells.

26. 23) Compare the structure and function of tight junctions, desmosomes and gap junctions Tight Junctions: These seal cell membranes together to eliminate space between cells. They hold cells together so they can work as one and they regulate the transfer of substances between cells. Desmosomes: These connect to adjacent cells and hold them together, the part that attaches to the cells are cadherins or adhesive proteins. The cytoskeletal filaments inside of the cytoplasm connect to a cytoplasmic plaque. Gap Junctions: These are small passageways connecting cells where small substances can pass through.

27. 24) Relate plasma membrane structure to active and passive transport mechanisms. Differentiate between these transport processes relative to energy source, substances transported, direction, and mechanism

28. 25) Describe the role of the glycocalyx when cells interact with their environment Glycocalyx is the slime layer or capsule that surrounds the cell and protects the cell from dangers of the environment, helps the cell to adhere to many different environments and contains and hold nutrients that the cell may need to survive.

29. 26) Discuss the structure and function of the mitochondria Structure • Organelle stored in the cytoplasm • Have an oblong shape with two membranes • They have their own set of DNA Function • Produce energy for the cell using food molecules • Generates ATP, which is the energy that cells use

30. 27) Discuss the structure and function of ribosomes, the endoplasmic reticulum and the Golgi apparatus including functional interrelationships among these organelles

31. 28) Compare the functions of lysosomes and peroxisomes

32. 29) Describe the process of DNA replication DNA Replication The enzyme helicase splits and parental DNA strands apart with ATP that breaks the hydrogen bonds between the base pairs. RNA primase adds a short sequence of RNA to the template strands. The RNA primer allows the DNA polymerase III to start the synthesis of the new strands. The replication process occurs in a 5prime to 3prime direction. The leading strand is replicated continuously and the lagging strand is replicated using many okazaki fragments. The okazaki fragments are then sealed with ligase. DNA polymerase I then removes all the RNA primers and replaces it with DNA. At the end of this you are left with two daughter strands of DNA. Then polymerase proofreads for any mistakes.

33. 30) Name two phases of protein synthesis and describe the roles of DNA, mRNA, tRNA and rRNA. Compare triplets, codons and anticodons. rRNA is ribosomal RNA. This is the part of a ribosome that perfroms protein synthesis. Codons – These are a sequence of three nucleotides that code for amino acids. Triplets – These are the same as condons and they are called this because they are triplets of nucleotides. Anticodons – These are the condons base pairs.

34. 31) List several structural and functional characteristics of epithelial tissue.

35. 32) Name, classify and describe various types of epithelia, also indicate their chief functions and locations. • simple squamous: This type is composed of a single layer of flattened, scale- or plate-like cells. It is quite common in the body. The large body cavities and heart, blood vessels and lymph vessels are typically lined by a simple squamous epithelium. The nuclei of the epithelial cells are often flattened and egg-shaped, and they are located close to the center of the cells. • simple cuboidal: Cells appear cuboidal in sections perpendicular to the surface of the epithelium. Viewed from the surface of the epithelium they look rather like small polygons. Simple cuboidal epithelium occurs in small excretory ducts of many glands, the follicles of the thyroid gland, the tubules of the kidney and on the surface of the ovaries. • simple columnar: The cells forming a simple columnar epithelium are taller than they are wide. The nuclei of cells within the epithelium are usually located at the same height within the cells - often close to the base of the cells. • pseudostratified-highly modified: These line the respiratory passages and they clear dust and the particles from the airways.

36. #32 Continued • stratified squamous: These cells protect the cells beneath them. They are found on the skin, throat, vagina and mouth. • stratified cuboidal: These cells line the ducts of mammary, sweat glands and the pancreas. They protect other cells. • stratified columnar: These cells protect other cells by secreting fluids for lubrication of the body cavities. They are found in parts of the pharynx, the male urethra and vas deferens. • transitional epitheliums: These are found in the urinary tracts and they expand and contract to protect it.

37. 33) Define gland. Differentiate between exocrine and endocrine glands and multicellular and unicellular glands. Gland: a cell or group of cells that produce a secretion Exocrine Gland: They have ducts aimed toward the surface of the body. Endocrine Gland: They are the glands where hormones are produced. Multicellular Gland: They have much more complex ducts and secretory units than unicellular. Unicellular Gland: These glands are simple and found in the epithelial linings of respiratory and intestinal tracts.

38. 34) Describe the types of connective tissue found in the body and indicate their characteristic functions. Loose Connective Tissue: This tissue connects the epithelia to the tissues beneath it. Adipose Tissue: This stores food and insulates organs. Cartilage: This provides shock absorption for impact and holds bones together. Fibrous Connective Tissue: This is ligaments which connect bone to bone and tendons which connect bone to muscle. Bone: Bones provide structure and support to the body. Blood: Blood clots open wounds so that not much blood is lost.

39. 35) Describe the structure and function of cutaneous, mucous and serous membranes.

40. 36) Outline the process of tissue repair involved in normal healing of a superficial wound. • The Cell Cycle • Interphase • G1 The cells grows • DNA replication occurs • G2 molecules needed for division are produced II. Mitosis • Prophase is when the nucleolus disappears and the nuclear membranes disintegrates • Metaphase is when the chromosomes line up in the middle of the cell • Anaphase is when sister chromosomes are pulled to polar ends of the cell • Telophase is when nuclear membranes reform around the new sets of chromosomes III. Cytokinesis • The cytoplasm splits to form two new cells IV. The body repeats until the wound is healed

41. 37) Indicate the embryonic origin of each tissue class. Epithelial Class is derived from all three germ layers. The mesoderm, ectoderm and endoderm. Connective Class is derived from the mesoderm and ectoderm. Muscular Class is derived from the mesoderm and some from the ectoderm. Nervous Class is derived from the ectoderm germ layer. Endoderm is the inner germ layers Ectoderm is the outer germ layers Mesoderm is the middle germ layers

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