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B. Target specific screening – Target prioritization

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Cpds 10 6 s to few. A. Whole cell screening – Target Identification. Cpds 10 6 s to few. Genes 1000s to few. Select developable compounds Confirm antibacterial activity. Determine mode of action: Generate resistant mutants Genome re-sequencing Mechanistic screens. Preclinical candidate

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Cpds 106s to few

A. Whole cell screening – Target Identification

Cpds 106s to few

Genes 1000s to few

  • Select developable compounds
  • Confirm antibacterial activity
  • Determine mode of action:
  • Generate resistant mutants
  • Genome re-sequencing
  • Mechanistic screens
  • Preclinical candidate
  • selection
  • Cpd
  • series & Target
  • Whole cell antibacterial assays
  • HTS / focused screens
  • Screen for antibacterial activity

Assay develop. &

Compound screens

Med. Chem. & Biology

Computational Biol. & Microbiology

B. Target specific screening – Target prioritization

Genes 1000s to few

  • Gene expression
  • Gene essentiality
  • Spectrum / specificity
  • Tractability
  • Known mode of action
  • Expert scoring
  • Select developable compounds
  • Screen for antibacterial activity
  • Preclinical candidate
  • selection
  • Cpd
  • series & Target
  • Configure assays
  • HTS or focused screens
  • Lab validation
  • Select for screening
  • Top
  • Target list

Assay develop. &

Compound screens

Med. Chem. & Biology

Computational Biol. & Microbiology

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