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B. Target specific screening – Target prioritization PowerPoint PPT Presentation


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Cpds 10 6 s to few. A. Whole cell screening – Target Identification. Cpds 10 6 s to few. Genes 1000s to few. Select developable compounds Confirm antibacterial activity. Determine mode of action: Generate resistant mutants Genome re-sequencing Mechanistic screens. Preclinical candidate

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B. Target specific screening – Target prioritization

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B target specific screening target prioritization

Cpds 106s to few

A. Whole cell screening – Target Identification

Cpds 106s to few

Genes 1000s to few

  • Select developable compounds

  • Confirm antibacterial activity

  • Determine mode of action:

  • Generate resistant mutants

  • Genome re-sequencing

  • Mechanistic screens

  • Preclinical candidate

  • selection

  • Cpd

  • series & Target

  • Whole cell antibacterial assays

  • HTS / focused screens

  • Screen for antibacterial activity

Assay develop. &

Compound screens

Med. Chem. & Biology

Computational Biol. & Microbiology

B. Target specific screening – Target prioritization

Genes 1000s to few

  • Gene expression

  • Gene essentiality

  • Spectrum / specificity

  • Tractability

  • Known mode of action

  • Expert scoring

  • Select developable compounds

  • Screen for antibacterial activity

  • Preclinical candidate

  • selection

  • Cpd

  • series & Target

  • Configure assays

  • HTS or focused screens

  • Lab validation

  • Select for screening

  • Top

  • Target list

Assay develop. &

Compound screens

Med. Chem. & Biology

Computational Biol. & Microbiology


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