Cpds 10
Download
1 / 1

B. Target specific screening – Target prioritization - PowerPoint PPT Presentation


  • 97 Views
  • Uploaded on

Cpds 10 6 s to few. A. Whole cell screening – Target Identification. Cpds 10 6 s to few. Genes 1000s to few. Select developable compounds Confirm antibacterial activity. Determine mode of action: Generate resistant mutants Genome re-sequencing Mechanistic screens. Preclinical candidate

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about ' B. Target specific screening – Target prioritization' - coral


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript

Cpds 106s to few

A. Whole cell screening – Target Identification

Cpds 106s to few

Genes 1000s to few

  • Select developable compounds

  • Confirm antibacterial activity

  • Determine mode of action:

  • Generate resistant mutants

  • Genome re-sequencing

  • Mechanistic screens

  • Preclinical candidate

  • selection

  • Cpd

  • series & Target

  • Whole cell antibacterial assays

  • HTS / focused screens

  • Screen for antibacterial activity

Assay develop. &

Compound screens

Med. Chem. & Biology

Computational Biol. & Microbiology

B. Target specific screening – Target prioritization

Genes 1000s to few

  • Gene expression

  • Gene essentiality

  • Spectrum / specificity

  • Tractability

  • Known mode of action

  • Expert scoring

  • Select developable compounds

  • Screen for antibacterial activity

  • Preclinical candidate

  • selection

  • Cpd

  • series & Target

  • Configure assays

  • HTS or focused screens

  • Lab validation

  • Select for screening

  • Top

  • Target list

Assay develop. &

Compound screens

Med. Chem. & Biology

Computational Biol. & Microbiology


ad