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9. 1 肿瘤与癌症 癌 ( cancer ) 是一群不受生长调控而繁殖的细胞,也称恶性肿瘤。良性肿瘤则是一群仅局限在自己的正常位置,且不侵染周围其它组织和器官的细胞。 PowerPoint PPT Presentation


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9 疾病与人类健康. 9. 1 肿瘤与癌症 癌 ( cancer ) 是一群不受生长调控而繁殖的细胞,也称恶性肿瘤。良性肿瘤则是一群仅局限在自己的正常位置,且不侵染周围其它组织和器官的细胞。. 图 9-1 肿瘤组织示意图. 癌基因 ( oncogene ) 可分为两大类: 一类是 病毒癌基因 ( viral oncogene , V-onc ), 编码病毒癌基因的主要有 DNA 病毒和 RNA 病毒。. DNA 病毒 包括乙型肝炎病毒、 SV40 和多瘤病毒、乳头瘤病毒、腺病毒、疱疹病毒和痘病毒。

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9. 1 肿瘤与癌症 癌 ( cancer ) 是一群不受生长调控而繁殖的细胞,也称恶性肿瘤。良性肿瘤则是一群仅局限在自己的正常位置,且不侵染周围其它组织和器官的细胞。

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9

9. 1

cancer


9-1


oncogene

viral oncogeneV-oncDNARNA


DNASV40

RNAretrovirus onc


C-onc


9.1.1

Rous1910RNA


6-9kbRNAgagenvenvgag


9-2


9-3


RNADNADNADNADNA

DNAprovirusmRNA



9-4 C-myc


V-onc

onc


9. 1. 2

()


9-7 Aflatoxin


3

erbBneufmsmassrc

mossisfps

mycetsjunmyb


6

GTP


9. 1. 3


8-8


1

ras2.1104p21T24 DNAHa-rasNlH/3T3DNA


Hs242Ha-rasp2161

p21


9-9 ras


2LTR

LTRlong terminal repeatLTR

LTRc-myc 5c-myc


3

c-myc8q24IgH14q32Ig22q12Igk2p11

Burkittc-mycIgHIgkIgIgc-mycIgc-myc


abl922bcr


9-10 abl


45BurkittC-mycLTR

5


9. 1. 4

1


gene territoryDNAgene territorial effect


c-myc8c-mycBurkittc-mycc-myc


c-myc515kbc-myc3kbc-myc

c-myc


2

3


SSVV-rasPDGF SrcV-erbEGF


3


p53p53p53


4


9-11


8.2HIV

HIVAIDSRetroviridae1983MontaginerGalloHIV


HIV I45%

HIV II75%8-4

HIVHIV I


HIVTB

HIVHIV


8.2.1 HIV

100nmgp41gp120p24p18RNA


8-12 HIV Igp120gp41MACANCRT


8.2.2 HIV

1.HIV

HIVRNARNA9.7kbRNA5m7G5GmpNp3(A)

5LTRgagpropolenv3LTR


HIV I3HIVTatRev

HIV I46


8-13 HIV I


2. HIV

HIV3gag5.5104(p55)HIVp17p24p15P24p17HIVCA(MA)p15RNA(NC)p9p7


Polp66p32

polgagprop22HIV

env8.81041.6105HIVgp160gp120gp41


gp120CD4GGPCR

gp41TMHIV


8-14 HIV ICD4


3.HIV

1V3301-324gp41616-632724-751

2TTT2T1105-117C1421-436C4T308-3223Tgp41


3CD4423-427C4gp120


8.2.3 HIV

HIVRNARNADNADNADNA


mRNARNA


8-15 HIV I


8.2.4 HIV

HIVHIVHIV,HIV

70%2-41-2HIV


HIVHIVPGLAPC


HIV

HIVgp120CD4

TCD4gp120


HIVgp120CD4T


8.2.5

HIV

HIV8-7


8-21 a.DNAb.


8.3 HBV

hepatitis virusHAVHBVHCVHDVHEV5


RNARNA

RNAHBV

(A)RNA


8.3.1

1986DNA1990


HBV42nm

27nmDNADNA


8-22 HBV


8.3.2

DNA

L3.2kbS50%-80%5240bp


115TTCAC-CTCTGC-318421590DR1DR2


8-23 HBVayw

X

,II

S

PreS1


HBV

1SS226SHBS108-115S155S23SS2MHBSSS1S2LHBS


SHBS22nm70%-90%


2P25323/4SCX

P3/DNARNaseHP9.5105


3C639HBcAgN19CEHBeAg2.2104HBeAg


4XX154X


8.3.3 HBV

DNA


8-24 HBV


8.4

8.4.1

1990ADAT510%ADA


ex vivoin vivo

ex vivo


in vivo

DNA


8. 4. 2


1

DNA

4.5kblacZHSV-1UL44CXba IHSVUL44HSV


2


3

DNARNADNA


4

1


2

kbkb


gal 4VP16/gal 4 DNA


8-26


PR-LBDRU486RU486RU486RU486PR-LBDVP16gal 4 DNAgal 4


3


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