9
This presentation is the property of its rightful owner.
Sponsored Links
1 / 92

9. 1 肿瘤与癌症 癌 ( cancer ) 是一群不受生长调控而繁殖的细胞,也称恶性肿瘤。良性肿瘤则是一群仅局限在自己的正常位置,且不侵染周围其它组织和器官的细胞。 PowerPoint PPT Presentation


  • 52 Views
  • Uploaded on
  • Presentation posted in: General

9 疾病与人类健康. 9. 1 肿瘤与癌症 癌 ( cancer ) 是一群不受生长调控而繁殖的细胞,也称恶性肿瘤。良性肿瘤则是一群仅局限在自己的正常位置,且不侵染周围其它组织和器官的细胞。. 图 9-1 肿瘤组织示意图. 癌基因 ( oncogene ) 可分为两大类: 一类是 病毒癌基因 ( viral oncogene , V-onc ), 编码病毒癌基因的主要有 DNA 病毒和 RNA 病毒。. DNA 病毒 包括乙型肝炎病毒、 SV40 和多瘤病毒、乳头瘤病毒、腺病毒、疱疹病毒和痘病毒。

Download Presentation

9. 1 肿瘤与癌症 癌 ( cancer ) 是一群不受生长调控而繁殖的细胞,也称恶性肿瘤。良性肿瘤则是一群仅局限在自己的正常位置,且不侵染周围其它组织和器官的细胞。

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -

Presentation Transcript


9 1 cancer

9

9. 1

cancer


9 1 cancer

9-1


9 1 cancer

oncogene

viral oncogeneV-oncDNARNA


9 1 cancer

DNASV40

RNAretrovirus onc


9 1 cancer

C-onc


9 1 cancer

9.1.1

Rous1910RNA


9 1 cancer

6-9kbRNAgagenvenvgag


9 1 cancer

9-2


9 1 cancer

9-3


9 1 cancer

RNADNADNADNADNA

DNAprovirusmRNA


9 1 cancer


9 1 cancer

9-4 C-myc


9 1 cancer

V-onc

onc


9 1 cancer

9. 1. 2

()


9 1 cancer

9-7 Aflatoxin


9 1 cancer

3

erbBneufmsmassrc

mossisfps

mycetsjunmyb


9 1 cancer

6

GTP


9 1 cancer

9. 1. 3


9 1 cancer

8-8


9 1 cancer

1

ras2.1104p21T24 DNAHa-rasNlH/3T3DNA


9 1 cancer

Hs242Ha-rasp2161

p21


9 1 cancer

9-9 ras


9 1 cancer

2LTR

LTRlong terminal repeatLTR

LTRc-myc 5c-myc


9 1 cancer

3

c-myc8q24IgH14q32Ig22q12Igk2p11

Burkittc-mycIgHIgkIgIgc-mycIgc-myc


9 1 cancer

abl922bcr


9 1 cancer

9-10 abl


9 1 cancer

45BurkittC-mycLTR

5


9 1 cancer

9. 1. 4

1


9 1 cancer

gene territoryDNAgene territorial effect


9 1 cancer

c-myc8c-mycBurkittc-mycc-myc


9 1 cancer

c-myc515kbc-myc3kbc-myc

c-myc


9 1 cancer

2

3


9 1 cancer

SSVV-rasPDGF SrcV-erbEGF


9 1 cancer

3


9 1 cancer

p53p53p53


9 1 cancer

4


9 1 cancer

9-11


9 1 cancer

8.2HIV

HIVAIDSRetroviridae1983MontaginerGalloHIV


9 1 cancer

HIV I45%

HIV II75%8-4

HIVHIV I


9 1 cancer

HIVTB

HIVHIV


9 1 cancer

8.2.1 HIV

100nmgp41gp120p24p18RNA


9 1 cancer

8-12 HIV Igp120gp41MACANCRT


9 1 cancer

8.2.2 HIV

1.HIV

HIVRNARNA9.7kbRNA5m7G5GmpNp3(A)

5LTRgagpropolenv3LTR


9 1 cancer

HIV I3HIVTatRev

HIV I46


9 1 cancer

8-13 HIV I


9 1 cancer

2. HIV

HIV3gag5.5104(p55)HIVp17p24p15P24p17HIVCA(MA)p15RNA(NC)p9p7


9 1 cancer

Polp66p32

polgagprop22HIV

env8.81041.6105HIVgp160gp120gp41


9 1 cancer

gp120CD4GGPCR

gp41TMHIV


9 1 cancer

8-14 HIV ICD4


9 1 cancer

3.HIV

1V3301-324gp41616-632724-751

2TTT2T1105-117C1421-436C4T308-3223Tgp41


9 1 cancer

3CD4423-427C4gp120


9 1 cancer

8.2.3 HIV

HIVRNARNADNADNADNA


9 1 cancer

mRNARNA


9 1 cancer

8-15 HIV I


9 1 cancer

8.2.4 HIV

HIVHIVHIV,HIV

70%2-41-2HIV


9 1 cancer

HIVHIVPGLAPC


9 1 cancer

HIV

HIVgp120CD4

TCD4gp120


9 1 cancer

HIVgp120CD4T


9 1 cancer

8.2.5

HIV

HIV8-7


9 1 cancer

8-21 a.DNAb.


9 1 cancer

8.3 HBV

hepatitis virusHAVHBVHCVHDVHEV5


9 1 cancer

RNARNA

RNAHBV

(A)RNA


9 1 cancer

8.3.1

1986DNA1990


9 1 cancer

HBV42nm

27nmDNADNA


9 1 cancer

8-22 HBV


9 1 cancer

8.3.2

DNA

L3.2kbS50%-80%5240bp


9 1 cancer

115TTCAC-CTCTGC-318421590DR1DR2


9 1 cancer

8-23 HBVayw

X

,II

S

PreS1


9 1 cancer

HBV

1SS226SHBS108-115S155S23SS2MHBSSS1S2LHBS


9 1 cancer

SHBS22nm70%-90%


9 1 cancer

2P25323/4SCX

P3/DNARNaseHP9.5105


9 1 cancer

3C639HBcAgN19CEHBeAg2.2104HBeAg


9 1 cancer

4XX154X


9 1 cancer

8.3.3 HBV

DNA


9 1 cancer

8-24 HBV


9 1 cancer

8.4

8.4.1

1990ADAT510%ADA


9 1 cancer

ex vivoin vivo

ex vivo


9 1 cancer

in vivo

DNA


9 1 cancer

8. 4. 2


9 1 cancer

1

DNA

4.5kblacZHSV-1UL44CXba IHSVUL44HSV


9 1 cancer

2


9 1 cancer

3

DNARNADNA


9 1 cancer

4

1


9 1 cancer

2

kbkb


9 1 cancer

gal 4VP16/gal 4 DNA


9 1 cancer

8-26


9 1 cancer

PR-LBDRU486RU486RU486RU486PR-LBDVP16gal 4 DNAgal 4


9 1 cancer

3


  • Login