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TGF b 1 - + + + + - + + + + +

A. BxPC-3 HeLa. MEK1 inhibitor + +. a V b 6 antibody + + . TGF b 1 RII antibody + + + . TGF b 1 - + + + + - + + + + +. p130 Cas. SOS1/2. pp125 FAK. HeLa. BxPC-3. +. -. latent TGF- b 1. B. C. -. +. mature TGF- b 1. p125 FAK.

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TGF b 1 - + + + + - + + + + +

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  1. A BxPC-3 HeLa MEK1 inhibitor + + aVb6 antibody + + TGFb1 RII antibody + + + TGFb1 - + + + + - + + + + + p130Cas SOS1/2 pp125FAK HeLa BxPC-3 + - latent TGF-b1 B C - + mature TGF-b1 p125FAK latent TGF-b1 SMAD4 mature TGF-b1

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