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TGF- β Receptor II and Gastric Cancer . Demi Dabor-Alloh. TGF- β Receptor II is a trans-membrane serine/threonine kinase. TGF β signalling regulates many cell processes. including : Growth Inhibition Cell Migration Invasion Epithelial – Mesenchymal Transition

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Tgf receptor ii and gastric cancer

TGF-βReceptor II and Gastric Cancer

Demi Dabor-Alloh


Tgf receptor ii is a trans membrane serine threonine kinase
TGF-β Receptor II is a trans-membrane serine/threonine kinase


Tgf signalling regulates many cell processes
TGF β signalling regulates many cell processes

  • including:

    • Growth Inhibition

    • Cell Migration

    • Invasion

    • Epithelial – Mesenchymal Transition

    • Extracellular Matrix Remodelling

    • Immune - suppression


Knocking out TGF-β receptor II caused embryonic lethality and defects of yolk sac haematopoiesis and vasculogenesis


Gastric c ancer is the second most frequent cause of cancer death in the world after lung cancer
Gastric cancer is the second most frequent cause of cancer death in the world after lung cancer.


Some p atients with gastric cancer have mutations that truncate the tgf rii protein
Some patients with gastric cancer have mutations that truncate the TGF-βRII protein


The tgf paradox it has cytostatic effects vs tumour favouring effects
The TGF-βParadox: it has Cytostatic effects vs. tumour favouring effects


Surgery is the primary treatment for gastric cancer
Surgery is the primary treatment for gastric cancer

Endoscopic Mucosal Resection

Total Gastrectomy

http://www.hopkins-gi.org


Works cited
Works Cited

Oshima, M., Oshima, H., Taketo, M.M, 1996. TGF-β Receptor Type II Deficiency Results in Defects of Yolk Sac Hematopoesis and Vasculogenesis. Developmental Biology, 179, pp297 – 302.

Yang, H.K., Kang S.H., Kim, Y.S., et al, 1999. Truncation of the TGF-β type II receptor gene results in insensitivity to TGF-β in human gastric cancer cells. Oncogene, 18, pp2213 – 2219.

Akhurst, R.J., Derynck R, 2001. TGF-βsignilling in cancer – a double-edged sword. Trends in Cell Biology, 11 (11), pp44 – 49.

Bachman, K.E., Park, B.H, 2005. Duel nature of TGF-β signalling: tumor suppressor vs. tumor promoter. Current Opinion in Oncology, 17, pp49 – 54.

Akhurst, R.J., Hata, A, 2012. Targeting the TGF-β signalling pathway in disease. Nature, 11, pp790 – 807.

Narayan, S., Thangasamy, T., Balusu, R, Transforming Growth Factor – Beta Receptor Signalling in Cancer, 2005. Frontiers in Bioscience, 10, pp1135 – 1145.

Jakowlew, S, 2006. Transforming growth factor- βin cancer and metastasis. Cancer Metastasis Review, 25, pp435 – 457.

Mishra, L., Shetty, K., Tang,Y., et al, 2005. The role of TGF- βand Wntsignaling in gastrointestinal stem cells and cancer. Oncogene, 24, pp5775 – 5789.

de Caestecker, M.P., Piek, E., Roberts, A.B, 2000. Role of Transforming Growth Factor-βSignaling in Cancer. Journal of the National Cancer Institute, 92 (1), pp388 – 402.

Becker, K.F., Keller, G, 2010. Gastric Cancer, Encyclopaedia of Life Sciences.


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