Improving Breast Biopsy using IVUS probes

1. Improving Breast Biopsyusing IVUS probes Client: Dr. Kelcz Team: Megan Buroker Kevin Johnson Advisor: Prof. Justin Williams Noelle Simatic Joe Zechlinski

3. Problem Statement • Goal • To improve biopsy yield by local imaging during MRI and Ultrasound guided stereotatic biopsy procedure. • Motivation • During biopsy procedures small tumors are often covered up by the biopsy needle yielding procedures with low specificity.

4. Guided Core Biopsy First visit • Initial mammographic/MR image • Positive diagnosis—suspicious lesions Second visit • Second MR image—insertion of plastic clip • Third MR image—check placement • Needle Insertion • Exact location never verified • Perform biopsy Results • Pathological analysis

6. Design Alternative 1 Optical Fluorescence • Prof. Nimmi Ramanujam • Photons excite tissue • Molecules emit frequency shifted photons • Fiberoptics record and transmit IR waves • Characteristic tissue response • NADH, FAD, and collagen

7. Design Alternatives 2 & 3Intravascular Ultrasonic Probes • Used to Image Arteries • Consist of Catheter & Ultrasonic Probe • 2-3 mm in diameter • Allow cross-sectional imaging of arteries • Depend on reflection of imaging area • Image 1-2 cm around probe • Waves 20-30Mhz

8. Design Alternative 2 Ultrasonic Biopsy Needle • Create a biopsy needle with a built in probe • Allows for 360 degree imaging • Would require a multi-transducer array • Needs to be sterile • Requires redesign of IVUS probe • Could be modified to incorporate 3D ultrasonic micro arrays in the near future

9. Design Alternative 3Catheter Based IVUS Probe • Use existing IVUS probes • Insert probe between scans • Allow for limited view outside • Use either rotational IVUS or multi-transducer type • No new materials needed

10. Design Comparison FiberopticIntegrated IVUSCatheter IVUS Price 2 0 10 Measurement 8 10 5 MRI Compatibility 10 7 7 Ease of Use 7 10 7 Ethics of use 2 9 9 Total 29 36 38

11. Future Work • Testing • Phantoms • Real specimens • Possible re-build of IVUS probe into needle • Rotational vs. multi-transducer models in catheter based measurement

12. Questions?