Chromosome 8
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Chromosome 8. By: Taylor Thorne. General Info. 146 million base pairs Chromosome 8 contains 1247 genes – 2 genes not placed About 4.5% to 5% of the chromosome is sequenced Size: One of the largest genes … 9 th largest Chromosomes X,1,2,3,4,5,6, and 7 are larger then 8. EYA1.

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Chromosome 8

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Chromosome 8

Chromosome 8

By: Taylor Thorne


General info

General Info

  • 146 million base pairs

  • Chromosome 8 contains 1247 genes– 2 genes not placed

  • About 4.5% to 5% of the chromosome is sequenced

  • Size: One of the largest genes… 9th largest

    • Chromosomes X,1,2,3,4,5,6, and 7 are larger then 8


Chromosome 8

EYA1

  • Name: Eyes absent homolog 1 (drosophila)

  • Location:8q13.3

  • Mutations:

    • Branchiootorenal syndrome

      • disrupts the development of tissues in the neck and causes malformations of the ears and kidneys

    • Anterior segment anomalies and cataract

      • Eye problems

    • Otofaciocervical syndrome

      • Abnormalities in the ears, neck, and face


Chromosome 8

WRN

  • Name: Werner Syndrome RecQ helicase-like

  • Location: 8p12

  • Mutations:

    • Werner syndrome

      • Accelerated or premature aging

      • Located at 8p12-p11.2


Chromosome 8

St18

  • Name: suppression of tumorigenicity 18

  • Location: 8q11.23

  • Mutations:

    • Breast carcinoma

    • Zinc finger protien


Chromosome 8

HR

  • Name: Hairless homolog (mouse)

  • Location: 8p21.2

  • Mutations:

    • Alopecia universalis

      • Condition that causes round patches of hair loss

    • Atrichia with papular lesions

      • A rare syndrome characterized by the loss of hair soon after birth and the eventual development of a popular rash that covers all areas of skin.

    • Hypotrichosis, Marie Unna type

      • Hair grows in when born but begins to fall out by adolesence


Linked genes

Linked Genes

  • C8orf74 is linked to FAM86B1

    • chromosome 8 open reading frame 74 linked to family with sequence similarity 86, member B1 (both linked to 8p23.1)

  • RPLP1P9 is linked to GRS

    • ribosomal protein linked to glutathione reductase


Linked genes1

Linked genes

  • Nicotinic Receptor gene

    • Due to introgressed chromosome 8

  • Perfect Pitch

    • In those if European ancestry

  • Cancer

    • Linked on NRG1 (neuregulin-1)

    • Especially breast cancer

Introgressed: the movement of a gene from one species into the gene pool of another by backcrossing an interspecific hybrid with one of its parents


Linked genes2

Linked Genes

  • Also linked to

    • Schizophrenia

    • Cataracts

    • Hair loss


Chromosome 8 with genes

Chromosome 8 with Genes


Chromosome 8

Dyads are duplicated chromosomes


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