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Chromosome

Supplemental Figure 1. Tumor samples. Normal samples. Chromosome. Supplemental Figure 2. B. A. Percent. Number of protein altering mutations. Samples. Supplemental Figure 3. PIK3CA. N202Y. E545K. T313R. p85 binding domain. Ras binding domain. C2 domain. Helical domain.

jermaine-lindsay
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Chromosome

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  1. Supplemental Figure 1 Tumor samples Normal samples Chromosome

  2. Supplemental Figure 2 B A Percent Number of protein altering mutations Samples

  3. Supplemental Figure 3 PIK3CA N202Y E545K T313R p85 binding domain Ras binding domain C2 domain Helical domain Kinase domain V317- **Y155H PTEN S287* Phos- phatase domain C2 domain

  4. Rev. Supplemental Figure 4 SCLC 042 PIK3CA(Vf*: 46.7%) genome_mut_syntax: g.3:178919119A>T aa_mut_syntax: p.N202Y (Substitution-Missense) SCLC 038 Rev. PIK3CACOSMICid: 764 (Vf*: 60.7%) genome_mut_syntax: g.3:178936091G>A aa_mut_syntax: p.E545K (Substitution-Missense) SCLC 058 ROS1(Vf*: 41.2%) genome_mut_syntax: g.6:117641077C>T aa_mut_syntax: p.V1965A (Substitution-Missense) SCLC 018 Rev. ROS1(Vf*: 11.5%) genome_mut_syntax: g.6:117631325C>A aa_mut_syntax: p.R2118I (Substitution-Missense) SCLC 024 KIT(Vf*: 60.0%) genome_mut_syntax: g.4:55589771_3 ACG del aa_mut_syntax: p.Y418del (Deletion-In frame)

  5. Supplemental Figure 5 A B Chromosome Chromosome GISTICq score GISTICq score

  6. Supplemental Figure 6

  7. Supplemental Figure 7 A B C

  8. Supplemental Figure 8 A B C PIK3CA p-AKT AKT p-S6RP S6RP GAPDH siNC #1 #2 #3 siPIK3CA

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