Total Synthesis of Cribrostatin IV and ET-743

Sep 19, 2014

380 likes | 571 Views

Total Synthesis of Cribrostatin IV and ET-743. Literature Meeting Presented by Nancy Labbé-Giguère January 30 th , 2006 Danishefvsky, S. et al , J. Am. Chem. Soc. 2005 , 127 , 4596-4598. D-amino acid. What is the structure of Fremy Salt? Mechanism of the reaction?. X.

Share Presentation

Embed Code

Link

danishefvsky
selective oxidation
substrate unstable
literature meeting
mildly basic conditions
nancy labb gigu

airell

Download Presentation

Total Synthesis of Cribrostatin IV and ET-743

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

Total Synthesis of Cribrostatin IV and ET-743 Literature Meeting Presented by Nancy Labbé-Giguère January 30th, 2006 Danishefvsky, S. et al, J. Am. Chem. Soc.2005, 127, 4596-4598.

D-amino acid

What is the structure of Fremy Salt? Mechanism of the reaction?

X • Substrate unstable to mildly basic conditions. • - Ketone was attacked by nucleophile. Cleavage of the β-dicarbonyl bond was observed.

PIFA ?? For the selective oxidation of ring A, see: Conant, J. B.; Fieser, L. F. J. Am. Chem. Soc.1924, 46, 1858.

Organic Synthesis: Total Synthesis of Target Molecules

Organic Synthesis: Total Synthesis of Target Molecules. Strategies & Tactics. Classification of Organic Synthesis. Linear Synthesis : tedious, inefficient but could be simple ex.) DNA, Peptide Synthesizer.

1.95k views • 62 slides

Total Synthesis of (-)-Conophylline and (-)-Conophyllidine

Total Synthesis of (-)-Conophylline and (-)-Conophyllidine. Tohru Fukuyama* @ University of Tokyo. Angew. Chem. Int. Ed. 2011, 50, 4884 –4887. Song jin 2011-06-25 Gong Group Meeting. ＊ (-)-Conophylline , isolated from Tabernaemontana divaricata( 狗牙花 ) in 1992.

475 views • 19 slides

Total Synthesis of (+)-Biotin

Total Synthesis of (+)-Biotin. Hoffmann-La Roche J. Am. Chem. Soc. 1982 , 104 , 6460-6462. Presented by Derek Ahneman. Hoffmann-La Roche, Inc. Swiss global health care company Founded by Fritz Hoffmann-La Roche in 1896 Headquartered in Basel, Switzerland

1.3k views • 7 slides

Total Synthesis of (+)- Haplophytine

Total Synthesis of (+)- Haplophytine. Olivier René Prof. Keith Fagnou Prof. Louis Barriault. Discovery of (+)- Haplophytine. The Mexican flower Haplophyton cimicidum : An efficient insecticide valued by Aztecs. Haplophyton cimicidum. Source: www.fireflyforest.com.

1.14k views • 56 slides

Total Synthesis of (+)- Cortistatin A

Malcolm P. Huestis Supervisor: Keith Fagnou. Total Synthesis of (+)- Cortistatin A. Marine Sponge Corticium simplex (22 mg from 1.5 kg organism). -Selectively inhibits angiogenesis. -IC 50 = 1.8 nM.

953 views • 55 slides

Total Synthesis of (+)- Saxitoxin

Total Synthesis of (+)- Saxitoxin. Ye- Geun Song CHEM 635 May 15 th , 2012 Fleming, J. J.; Du Bois, J. J. Am. Chem . Soc. 2006 , 128 , 3926. Saxitoxin. A neurotoxin naturally produced by certain species of marine dinoflagellates (plankton) and cyanobacteria (green algae).

363 views • 11 slides

Total Synthesis of Bryostatin 1

Total Synthesis of Bryostatin 1. Brittany Wheeler Chemistry Department University of Maryland. J. Am. Chem. Soc. Keck, G. E.; Poudel , Y. B.; Cummins, T. J.; Rudra , A.; Covel , J.A. 2011, 133, 744-747. Gary E. Keck. Professor at the University of Utah, Salt Lake City, Utah.

540 views • 16 slides

Total synthesis of (-)Quinocarcin

Total synthesis of (-)Quinocarcin. Mounuo Cheng 20091115. DX-52-1 R=CN Quinocarcinol R=H. Quinocarcin. terazomine. quinocarcinamide. quinocarcinamide. Jieping Zhu Jacs 2008,130, 7148-7152. Jieping Zhu Jacs 2008,130, 7148-7152. Catalytic enantioselective enolate alkylation under PTC.

543 views • 23 slides

Total Synthesis of (±)- Longifolene

Total Synthesis of (±)- Longifolene. Yiyun Peng March 4th, 2013. W. Oppolzer, T. Godel, J. Am. Chem. Soc. 1978, 100, 2583 – 2584. Professor Wolfgang Oppolzer. Biography: 1937 Born in Vienna, Austria 1960 Diploma at the University of Vienna

2.08k views • 6 slides

Total Synthesis of (±)-Indolizomycin

Total Synthesis of (±)-Indolizomycin. A presentation by Guillaume Pelletier November 22 th 2012. Structural and biological analysis.

1.32k views • 23 slides

Total Synthesis of Rapamycin

Total Synthesis of Rapamycin. Isolation and Structure Determination: Vézina, C.; Kudelski, A.; Sehgal, S. N. J. Antibiotics 1975 , 28 , 721. Swindells, D. C. N.; White, P. S.; Findlay, J. A. Can. J. Chem. 1978 , 56 , 2491. Findlay, J. A.; Radics, L. Can. J. Chem. 1981 , 59 , 49.

826 views • 45 slides

Total Synthesis Of (±)-Stenine

Total Synthesis Of (±)-Stenine. John D. Ginn and Albert Padwa Org. Lett . 2002 , 4(9), 1515-1517. Presented by. SRINIVASA RAO CHINTALA. Efforts toward the Total Synthesis of Stenine. 1990: D. J. Hart ( The Ohio State University ) 1995: P. Wipf ( University Of Pittsburgh )

292 views • 9 slides

Total Synthesis of (+)- Fastigiatine

Total Synthesis of (+)- Fastigiatine. Gretchen Peters February 10 , 2011. Shair Research Group. Total synthesis and chemical biology Focus of syntheses: “naturally occurring complex molecules that challenge the state-of-the-art of organic synthesis”

429 views • 14 slides

Total Synthesis of (+) Plicamine

Total Synthesis of (+) Plicamine. Ley et al, ACIE ( 2002 ) 41 , 2194. Bryan Klebon May 8, 2012. Steven Ley. BP Professor of Organic Chemistry, University of Cambridge Completed over 130 netural product synthesises

363 views • 12 slides

Total Synthesis of ( - )-Quinocarcin

Total Synthesis of ( - )-Quinocarcin. 李楠 2009.04.20. Stoltz. J. Am. Chem. Soc. , 2008 , 130 (51), 17270-17271 Myers. J. Am. Chem. Soc. , 2005 , 127 (48), 16796-16797 Zhu. J. Am. Chem. Soc. , 2008 , 130 (22), 7148-7152. inhibition of lung cancer activity against lymphocytic leukemia etc.

745 views • 24 slides

Total Synthesis of Brevenal

Total Synthesis of Brevenal. Jon D. Rainier Department of Chemistry, University of Utah. J. Am. Chem. Soc . 2011, 133, 3208–3216. Dinoflagellate-derived marine ladder toxin Interesting pentacyclic structure Fused ether architectures.

390 views • 19 slides

Total Synthesis of (+)-Discodermolide

Total Synthesis of (+)-Discodermolide. CHEM635 Kelsey Roberts Group B February 19, 2013. Patterson, I*; Florence, G. J.; Gerlach, K.; Scott, J. P. Agnew. Chem. Int. Ed. 2000 , 39, 377-380. Ian Paterson. Born in 1954 in Dundee, Scottland B.S. in Chemistry from U of Saint Andrews, 1976

373 views • 12 slides

Stereocontrolled Total Synthesis of ( + )-Vinblastine

Stereocontrolled Total Synthesis of ( + )-Vinblastine. Satoshi Yokoshima , Toshihiro Ueda, Satoshi Kobayashi, Ayato Sato, Takeshi Kuboyama , Hidetoshi Tokuyama, and Tohru Fukuyama Presented By William Reid 2/26/13. ( + )-Vinblastine. Isolated from Catharanthus roseus

560 views • 17 slides

Total Synthesis of (−)- Lepenine

Total Synthesis of (−)- Lepenine. Yiyun Peng 5/6/2014 doi.org/10.1021/ja503023h |J. Am. Chem. Soc. XXXX, XXX, XXX− XXX Yoshitake Nishiyama , Yuki Han- ya , Satoshi Yokoshima , and Tohru Fukuyama. Tohru Fukuyama’s Correction Crisis. Tohru Fukuyama’s Correction Crisis. Background.

548 views • 10 slides

Total Synthesis of Aplyviolene

Total Synthesis of Aplyviolene. M . J. Schnermann and L. E. Overman , J. Am. Chem. Soc. 2011 , 133 , 16425-16427. Total Synthesis of Aplyviolene. ] B. Sullivan and D. J. Faulkner, J. Org. Chem. 1984 , 49 , 3204-3206. Isolated from the marine sponge Dendrilla sp.

335 views • 9 slides

Total Synthesis of Isoschizogamine

Total Synthesis of Isoschizogamine. Guo Rui 2012.11.23. Introduction. Contents. Total Synthesis of (±)Isoschizogamine. Retrosynthetic Analysis of (±) Isoschizogamine. Total Synthesis of (±)Isoschizogamine. Total Synthesis of (±)Isoschizogamine. Total Synthesis of (±)Isoschizogamine.

597 views • 22 slides

Total Synthesis of (+) Plicamine

132 views • 12 slides

More Related