African trypanosomiasis Trypanosoma brucei - PowerPoint PPT Presentation

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African trypanosomiasis Trypanosoma brucei. Salivarian trypanosome groups. Trypanosoma vivax – Old and New World of large mammals – Mechanical transmission using many vectors Trypanosoma congolense – Old World of large mammals– Mouthpart development in Glossina

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African trypanosomiasis Trypanosoma brucei

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African trypanosomiasis trypanosoma brucei l.jpg

African trypanosomiasisTrypanosoma brucei


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Salivarian trypanosome groups

Trypanosoma vivax – Old and New World of large mammals –

Mechanical transmission using many vectors

Trypanosoma congolense – Old World of large mammals–

Mouthpart development in Glossina

Trypanosoma brucei/evansi –

brucei group includes: T. brucei brucei –nagana in cattle

T. brucei gambiense – chronic or West

African sleeping sickness

T. brucei rhodesiense – acute or East

African sleeping sickness

All have full development in Glossina

evansi group includes: T. evansi – mechanical transmission in

many vectors including

vampire bats

T. equinum – mechanically transmitted

by horse flies

T. equiperdum – sexually transmitted


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African trypanosomiasisTrypomastigote morphology


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African trypanosomiasisKinetoplast DNA changes


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African trypanosomiasisReservoir hosts

gazelle

gerenuk

impala

oryx


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African trypanosomiasis - Distribution

West African = Trypanosoma gambiense

East African = Trypanosoma rhodesiense


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African trypanosomiasisResistant and susceptible cattle

N’dama

Zebu


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African trypanosomiasisThe tsetse fly


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African trypanosomiasisLife cycle


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African trypanosomiasisAntigenic variation


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Immune response overview


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African trypanosomiasisDisease


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African trypanosomiasisDiagnosis


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African trypanosomiasisTreatment

Suramin - Pentamidine

(early)

Melarsoprol

(late)

DFMO

Aventis Pharm & WHO


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African trypanosomiasisPrevention and Control


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