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Hematology - PowerPoint PPT Presentation

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Hematology . Jan Bazner-Chandler CPNP, CNS, MSN, RN. Blood. Blood is the fluid of life Blood is composed of: Plasma RBC WBC Platelets. Plasma. Plasma consists of: 90% water. 10 % solutes: albumin, electrolytes and proteins.

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Jan Bazner-Chandler



  • Blood is the fluid of life

  • Blood is composed of:

    • Plasma

    • RBC

    • WBC

    • Platelets


  • Plasma consists of:

    • 90% water.

    • 10 % solutes: albumin, electrolytes and proteins.

    • Proteins consist of clotting factors, globulins, circulating antibodies and fibrinogen.

Red blood cells
Red Blood Cells

  • RBC’s travel through the body delivering oxygen and removing waste.

  • RBC’s are red because they contain a protein chemical called hemoglobin which is bright red in color.

  • Hemoglobin contains iron, making it an excellent vehicle for transporting oxygen and carbon dioxide.

Rbc s

Average life cycle is 120 days.

The bones are continually producing new cells.


White blood cells
White Blood Cells

  • The battling blood cells.

  • The white blood cells are continually on the look out for signs of disease.

  • When a germ appears the WBC will:

    • Produce protective antibodies.

    • Surround it and devour the bacteria.

Wbc s

  • WBC life span is from a few days to a few weeks.

  • WBC’s will increase when fighting infection.


Platelets are irregularly-shaped, colorless bodies that are present in blood.

Their sticky surface lets them form clots to stop bleeding.


Blood values
Blood Values present in blood.

  • CBC with differential and platelet count.

    • Hgb:

      • Normal levels are 11 to 16 g / dl

      • Panic levels are:

        • Less than 5 g / dl

        • More than 20 g / dl

Hematocrit present in blood.

  • Normal hematocrit levels are 35 to 44%.

    • Panic levels:

      • Hmct less than 15 %

      • Hmct greater than 60%

Hemoglobin and hematocrit
Hemoglobin and Hematocrit present in blood.

  • Can be used as a simple blood test to screen for anemia.

  • The CBC with differential would be used to help diagnose a specific disorder.

  • A bone marrow aspiration would be the most conclusive in determining cause of anemia – aplastic / leukemia.

Bone marrow
Bone Marrow present in blood.

Bone marrow is the spongy substance found in the center of the bones.

  • It manufactures bone marrow stem cells, which in turn produce blood cells.

    • Red blood cells – carry oxygen to tissue

    • Platelets – help blood to clot

    • White blood cells – fight infection

Bone marrow transplant
Bone Marrow Transplant present in blood.

  • Donor is placed under anesthesia.

  • Marrow is aspirated out of the iliac crest.

  • Marrow is filtered and treated to remove bits of bone and other unwanted cells and debris, transferred to a blood bag, and is infused into the patient’s blood just like at transfusion.

Bone marrow aspiration
Bone Marrow Aspiration present in blood.

Treatment modalities
Treatment Modalities present in blood.

  • Transfusion:

    • Packed red blood cells – anemia

    • Platelets – platelet dysfunction

    • Fresh frozen plasma – coagulation factors

Blood transfusions
Blood Transfusions present in blood.

  • 3 types of transfusion reactions

    • Hemolytic

    • Allergic

    • Febrile

Hemolytic reaction
Hemolytic Reaction present in blood.

  • Refers to an immune response against transfused blood cells.

  • Antigens, on the surface of red blood cells, are recognized as “foreign proteins” and can stimulate B lymphocytes to produce antibodies to the red blood cell antigens.

Hemolytic reaction1
Hemolytic reaction present in blood.

  • Flank pain

  • Fever

  • Chills

  • Bloody urine

  • Rash

  • Low blood pressure

  • Dizziness / fainting

Nursing management
Nursing Management present in blood.

  • Stop the blood transfusion.

  • Start normal saline infusion.

  • Take vital signs with blood pressure

  • Call the MD

  • Obtain blood sample and urine specimen.

  • Return blood to blood bank.

  • Document

Febrile reaction
Febrile Reaction present in blood.

  • Often occurs after multiple blood transfusions.

  • Symptoms:fever, chills, and diaphoresis.

  • Interventions:

    • Slow transfusion and administer antipyretic.

    • Administer antipyretic prior to administration.

Allergic reaction
Allergic Reaction present in blood.

  • Symptoms: rash, urticaria, respiratory distress, or anaphylaxis.

  • Interventions:

    • administer antihistamine before transfusion

    • Physician may order washed rbc’s

Hematologic conditions
Hematologic Conditions present in blood.

Alteration in hematologic status
Alteration in Hematologic Status present in blood.

  • Disorders of hemostasis or clotting factors

  • Structural or quantitative abnormalities in the hemoglobin.

  • Anemias

  • Aplastic Anemia

Genetic implications
Genetic Implications present in blood.

  • The following have a genetic link: implications for genetic screening and fetal diagnosis

    • Sickle cell anemia

    • Thalassemia

    • Hemophilia

Bleeding disorders
Bleeding Disorders present in blood.

  • Three types Hemophilia: males only

    • Type A most common – factor VIII deficiency

    • Type B - lack of factor IX (Christmas Disease)

    • Type C – lack of factor XI

      Von Willebrand Disease – 1% of population – men or women – prolonged bleeding time

Hemophilia type a
Hemophilia Type A present in blood.

  • Hemophilia type A is the deficiency of clotting factor VIII.

    • A serious blood disorder

    • Affects 1 in 10,000 males in the US

    • Autoimmune disorder with lowered level of clotting factor

    • All races and socio economic groups affected equally

Hemophilia present in blood.

  • Hemophilia is a sex-linked hereditary bleeding disorder

  • Transmitted on the X chromosome

  • Female is the carrier

  • Women do not suffer from the disease itself

Historical perspective
Historical Perspective present in blood.

  • First recorded case in Talmud Jewish text by an Arab physician – documentation of two brothers with bleeding after circumcision.

  • Queen Victoria is carrier and spread the disease through the male English royalty.

Goals of care
Goals of Care present in blood.

  • Goals of care:

    • Provide factor VIII (IX) to aid blood in clotting.

    • To decrease transmission of infectious agents in blood products; hepatitis & AIDS.

    • Future: gene therapy to increase production of clotting factor.

Symptoms present in blood.

  • Circumcision may produce prolonged bleeding.

  • As child matures and becomes more active the incidence of bleeding due to trauma increases

Symptoms present in blood.

  • May be mild, moderate or severe

  • Bleeding into joint spaces, hemarthrosis

  • Most dangerous bleed would be intracranial.

Diagnosis present in blood.

  • Presenting symptoms

  • Prolonged activated aPTT and decreased levels of factor VIII or IX.

  • Genetic testing to identify carriers

Treatment present in blood.

  • Products used to treat hemophilia are:

    • Fresh frozen plasma and cryoprecipitate which are from single blood donors and require special freezing.

    • Second generation of factor VIII are made with animal or human proteins.

Nursing diagnoses
Nursing Diagnoses present in blood.

  • Risk for injury

  • Pain with bleed especially into a joint

  • Impaired physical mobility

  • Knowledge deficit regarding disease and management of disease

Nursing interventions
Nursing interventions present in blood.

  • No rectal temps.

  • Replace the factor as ordered by physician.

  • Manage pain utilizing analgesics as ordered.

  • Maintaining joint integrity during acute phase: immobilization, elevation, ice.

  • Physical therapy to prevent flexion contraction and to strengthen muscles and joints.

  • Provide opportunities for normal growth and development.

Teaching present in blood.

  • Avoid aspirin which prolongs bleeding time in people with normal levels of factor VIII.

  • A fresh bleeding episode can start if the clot becomes dislodged.

  • Natural reactions in the body cause the clot that is no longer needed to “break down. This process occurs 5 days after the initial clot is formed.

Family education
Family Education present in blood.

  • Medic-Alert bracelet

  • Injury prevention appropriate for age

  • Signs and symptoms of internal bleeding or hemarthrosis

  • Dental checkups

  • Medication administration

Long term complications
Long Term Complications present in blood.

  • 20% develop neutralizing antibodies that make replacement products less effective.

  • Gene therapy providing continuous production of the deficient clotting factor could be the next major advance in hemophilia treatment.

Disseminated intravascular coagulation or dic
Disseminated Intravascular Coagulation or DIC present in blood.

  • DIC is an acquired coagulopathy that is characterized by both thrombosis and hemorrhage.

  • DIC is not a primary disorder but occurs as a result of a variety of alterations in health.

Assessment present in blood.

  • The most obvious clinical feature of DIC is bleeding.

  • Renal involvement = hematuria, oliguria, and anuria.

  • Pulmonary involvement = hemoptysis, tachypnea, dyspnea and chest pain.

  • Cutaneous involvement = petechiae, ecchymosis, jaundice, acrocyanosis and gangrene.

Management of dic
Management of DIC present in blood.

  • Treatment of the precipitating disorder.

  • Supportive care with administration of platelet concentration and fresh frozen plasma and coagulation factors.

  • Administration of heparin (controversial in children).

  • Heparin potentates anti-thrombin III which inhibits thrombin and further development of thrombosis.

Nursing diagnoses1
Nursing Diagnoses present in blood.

  • Altered tissue perfusion

  • Risk for injury

  • Anxiety

Nursing interventions1
Nursing Interventions present in blood.

  • Rigorous ongoing assessment of all body systems

  • Monitor bleeding

  • No rectal temps

  • Avoid trauma to delicate tissue areas

  • All injections sites and IV sites need to be treated like an arterial stick.

Prognosis present in blood.

  • Depends on the underlying disorder and the severity of the DIC.

ITP present in blood.

  • Idiopathic thrombocytopenic purpura

    • Idiopathic = cause is unknown

    • Thrombocytopenic = blood does not have enough platelets

    • Purpura = excessive bleeding / bruising

Immune thrombocytopenic purpura
Immune Thrombocytopenic Purpura present in blood.

  • Antibodies destroy platelets

  • Antibodies see platelets as bacteria and work to eliminate them

  • ITP is preceded by a viral illness

    • URI

    • Varicella / measles vaccine

    • Mononucleosis

    • Flu

Symptoms present in blood.

  • Random purpura

  • Epistaxis, hematuria, hematemesis, and menorrhagia

  • Petechiae and hemorrhagic bullae in mouth

Diagnostic tests
Diagnostic Tests present in blood.

  • Low platelet count

  • Peripheral blood smear

  • Antiplatelet antibodies

    Normal platelet count: 150,000 to 400,000

Management present in blood.

  • IV gamma globulin to block antibody production, reduce autoimmune problem

  • Corticosteroids to reduce inflammatory process

  • IV anti-D to stimulate platelet production

Sickle cell anemia
Sickle Cell Anemia present in blood.

  • Autosomal recessive disorder

  • Defect in hemoglobin molecule

  • Cells become sickle shaped and rigid

  • Lose ability to adapt shape to surroundings.

  • Sickling may be triggered by fever and emotional or physical stress

Pathophysiology present in blood.

  • When exposed to diminished levels of oxygen, the hemoglobin in the RBC develops a sickle or crescent shape; the cells are rigid and obstruct capillary blood flow, leading to congestion and tissue hypoxia; clinically, this hypoxia causes additional sickling and extensive infarctions.

Whaley & Wong Text present in blood.

Crescent shaped cells
Crescent Shaped Cells present in blood.

Body systems affected by ss
Body Systems Affected by SS present in blood.

  • Brain: CVA – paralysis - death

  • Eyes: retinopathy – blindness

  • Lungs: pneumonia

  • Abdomen: pain, hepatomegaly, splenomegaly (medical emergency due to possible rupture

  • Skeletal: joint pain, bone pain – osteomyelitis

  • Skin: chronic ulcers – poor wound healing

Vaso occlusive crisis
Vaso-occlusive Crisis present in blood.

Stasis of blood with clumping of cell in the microcirculation, ischemia, and infarction

  • Most common type of crisis; painful

  • Signs include fever, pain, tissue engorgement

Splenic sequestration
Splenic Sequestration present in blood.

  • Life-threatening / death within hours

  • Pooling of blood in the spleen

  • Signs include profound anemia, hypovolemia, and shock

  • Abdominal distention, pallor, dyspnea, tachycardia, and hypotension

Aplastic crisis
Aplastic Crisis present in blood.

  • Diminished production and increased destruction of red blood cells

  • Triggered by viral infection or depletion of folic acid

  • Signs include profound anemia, pallor

Nursing diagnoses2
Nursing Diagnoses present in blood.

  • Altered tissue perfusion

  • Pain

  • Risk for infection

  • Knowledge deficit regarding disease process

Nursing management hospital
Nursing Management - Hospital present in blood.

  • Increase tissue perfusion

    • Oxygen

    • Blood transfusion if ordered

    • Bed rest

  • Pain management

  • Hydration

    • IV fluids as ordered

    • Oral intake of fluids

Nursing management1
Nursing Management present in blood.

  • Adequate nutrition

  • Emotional Support

  • Discharge instructions

    • Information about disease management

    • Daily folic acid

    • Control of triggers

    • Prophylactic antibiotics

    • Immunizations / Pneumococcal

Patient education
Patient Education present in blood.

  • Necessity of following plan of care

  • Signs and symptoms of impending crisis.

  • Signs and symptoms of infection

  • Preventing hypoxia from physical and emotional stress

  • Proving adequate rest

Beta thalassemia
Beta-Thalassemia present in blood.

  • Hereditary / autosomal defect

  • Genetic defect on chromosome 11

  • Mediterranean descent

  • Defect in the beta globin gene

  • Beta globin chains are required for synthesis of hemoglobin A

Rbc characteristics

Microcytosis = small in size present in blood.

Hypochromia = decrease hemoglobin

Poikilocytosis = abnormal shape

RBC Characteristics

Treatment prognosis
Treatment / Prognosis present in blood.

  • Supportive

  • Blood transfusions as needed

  • Bone marrow transplant

Poor prognosis / death within 1st year due to septicemia or

heart failure.

Iron deficiency anemia
Iron Deficiency Anemia present in blood.

  • Most common nutritional deficiency

  • Depletion of iron stores

Abnormal laboratory values
Abnormal Laboratory Values present in blood.

  • Hemoglobin levels less than 8 g/dL

  • Decreased levels of Serum Iron or Total Iron Binding or Serum Ferritin

  • Microcytic and hypochromic red blood cells

IDA present in blood.

  • Occurs in children experiencing:

    • Rapid physical growth

    • Low iron intake

    • Inadequate iron absorption

    • Loss of blood

Symptoms present in blood.

  • Associated with low oxygenation of tissue:

    • Pallor

    • Fatigue

    • Shortness or breath

    • Irritability

    • Intolerance of physical work / exercise

Management present in blood.

  • Iron supplementation

    • Given in a.m. on an empty stomach

    • To avoid staining of teeth, give using a syringe, dropper or straw

    • Instruct caretaker that child may have dark-colored stools

Management present in blood.

  • Nutritional counseling

  • Infants younger than 12 months should be on formula until around 12 months of age

  • Infants 12 months or older

    • Decrease intake of milk

    • Introduce solid foods

  • Children: iron fortified cereals, foods, meat, green leafy vegetables

  • Teenagers: reduce junk food

Aplastic anemia
Aplastic Anemia present in blood.

  • Acquired or inherited

  • Normal production of blood cells in the bone marrow is absent or decreased.

  • A marked decrease in RBC’s, WBC’s and platelets.

Causes present in blood.

  • Exposure to drugs

  • Exposure to chemicals

  • Exposure to toxins

  • Infection

  • Idiopathic in nature

Blood characteristics

Neutophil less than 500 present in blood.

Platelet less than 20,000

Hemoglobin less than 7

Reticulocytes 1%

Nursing Diagnosis?

Blood Characteristics

Bone marrow reveals hypo-cellular and fatty marrow.

Management present in blood.

  • Immunosuppressive therapy

    • Antithymocyte globulin

      • Administered IV over 4 days

      • Response seen within 3 months

  • Bone Marrow Transplant

Hyper bilirubinemia
Hyper-bilirubinemia present in blood.

Hyperbilirubinemia present in blood.

  • Many babies have some jaundice. When they are a few days old, their skin slowly begins to turn yellow. The yellow color comes from the color of bilirubin. When red blood cells die, they break down and bilirubin is left. The red blood cells break down and make bilirubin. In newborns, the liver may not be developed enough to get rid of so much bilirubin at once. So, if too many red blood cells die at the same time, the baby can become very yellow or may even look orange. The yellow color does not hurt the baby's skin, but the bilirubin goes to the brain as well as to the skin. That can lead to brain damage.

Signs and symptoms
Signs and symptoms present in blood.

  • Very yellow or orange skin tones (beginning at the head and spreading to the toes)

  • Increased sleepiness, so much that it is hard to wake the baby

  • High-pitched cry 

  • Poor sucking or nursing 

  • Weakness, limpness, or floppiness

Photo therapy
Photo Therapy present in blood.

Fiberoptic blanket
Fiberoptic Blanket present in blood.

Nursing interventions2
Nursing Interventions present in blood.

  • Monitor bilirubin levels

  • Assess activity level – muscle tone – infant reflexes

  • Encourage po intake: May need to supplement with formula if inadequate breastfeeding

  • Weight daily to assess hydration status

  • Monitor stools – amount and number

  • Cover eyes while under bili-lights

  • Facilitate parent - infant bonding

    Loss of moro or startle reflex can indicate possible brain damage due to Kernicterus