TGF-β Superfamily - PowerPoint PPT Presentation

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TGF-β Superfamily

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  1. TGF-β Superfamily Transforming growth factor-β(TGF-β) is the founding member of a large superfamily of secreted polypeptide growth factors, which additionally includes activins, nodal, bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and others. From early development and continuously throughout adult life, TGF-β members carry out pivotal functions by regulating biological events ranging from gastrulation and organ morphogenesis to homeostatic tissue turnover. Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release. Identified in 1986, activin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual cycle. Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis, metabolism, homeostasis, immune response, wound repair, and endocrine function. https://www.creative-diagnostics.com/tgf-b-superfamily.htm