The pathways of oxidative phosphorylation
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The Pathways of Oxidative Phosphorylation. By A- aron L. and Jay-Crisp. Whole Show. The Pathway of Electron Transport. The electron transport chain is a collection of molecules embedded in the inner membrane of the mitochondria in Eukaryotic cells. Most components in a chain are protein

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The pathways of oxidative phosphorylation

The Pathways of OxidativePhosphorylation

By A-aron L. and Jay-Crisp



The pathway of electron transport
The Pathway of Electron Transport

  • The electron transport chain is a collection of molecules embedded in the inner membrane of the mitochondria in Eukaryotic cells.

    • Most components in a chain are protein

    • Exists in multi-protein complexes Number 1-4

  • Bound to these proteins are prosthetic groups and these are non-protein components essential for catalytic enzymes.


Atp molecular mill
ATP Molecular Mill

  • H+ Ions flowing down their gradient enter a half channel in a stator, which is anchored in the membrane.

  • H+ Ions enter binding sites within a rotor, changing the shape of each subunit so that the rotor spins within the membrane.

  • Each H+ Ion makes one complete turn before leaving the rotor and passing through a second half channel in the stator into the mitochondrial matrix.

  • Spinning of the rotor causes as internal rod to spin as well. This rod extends like a stalk into the knob below it, which is held stationary by part of the stator.

  • Turning of the rod activates catalytic sites in the knob that produce ATP from ADB and P


Yo dog what s the pathway to e trans
Yo Dog, What’s the Pathway to E-Trans.

  • Most of the remaining electron carriers between ubiquinone and oxygen are proteins call Cytochromes.

    • Prosthetic group, called a heme group

      • Has an Iron Atom that accepts and donates electrons.

  • The electron transport chain has several types of cytochromes each a different protein with a slightly different electron carrying heme group.

  • The electron transport chain does not produce ATP directly

    • Breaks down larger molecules in a Nine Fold Process until they becomes small enough, producing ATP as a product and H2O as a Bi-Product which then leads to CHEMIOSIS



Chemiosmosis1
Chemiosmosis

  • Populating the inner membrane of the mitochondrion or the prokaryotic plasma membrane are many copies of a protein complex, Called ATP Synthase

    • The enzyme that makes ATP from ADP and Inorganic Phosphate

    • ADP+ P = ATP


Chemiosmosis and oxidative phosphorylation
Chemiosmosis and Oxidative Phosphorylation

  • There is an electrochemical gradient across the cristae

  • Two Parts:

    • Difference in charge

    • Difference in Concentration


Electrochemical gradient
Electrochemical Gradient

The diffusion gradient of an ion, which is affected by both the concentration difference of an ion across a membrane and the ions tendency to move relative to the membrane potential….


Chemiosmosis and oxidative phosphorylation1
Chemiosmosis and Oxidative Phosphorylation

  • The Inner membrane is impermeable to protons.

  • The protons are forced through special proton channels that are coupled with ATP synthase


Chemiosmosis and oxidative phosphorylation2
Chemiosmosis and Oxidative Phosphorylation

  • The electrochemical gradient produces a proton-motive force (PMF) that moves the protons through this ATPase complex.

  • Each time a proton comes through the ATPase complex, the free energy of the electrochemical gradient is reduced and this energy is used to create ATP from ADP + P in the matrix.


Who found this out
Who found this out?

  • Peter Mitchell found all this out in 1961 and coined the term chemiosmosis because the energy that drives ATP production comes from the osmosis of protons. It took a long time for his theory to be accepted. He finally got his Nobel Prize in 1978.


Here yur gur
Here yur GUR!!!