nrneph.2009.67-pf1

Oct 13, 2014

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Figure 1 Renal survival of patients in our study with pauci-immune crescentic glomerulonephritis with and without ANCAs. Permission obtained from the American Society of Nephrology  Chen, M. et al. Antineutrophil cytoplasmic autoantibody negative pauci-immune crescentic glomerulonephritis.

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nrneph.2009.67-pf1

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Figure 1 Renal survival of patients in our study with pauci-immune crescentic glomerulonephritis with and without ANCAs Permission obtained from the American Society of Nephrology  Chen, M. et al. Antineutrophil cytoplasmic autoantibody negative pauci-immune crescentic glomerulonephritis. J. Am. Soc. Nephrol. 18, 599–605 (2007) Chen M et al. (2009)ANCA-negative pauci-immune crescentic glomerulonephritisNat Rev Nephrol doi:10.1038/nrneph.2009.67

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Figure 2 Features of subclinical or indolent ABMR, which is typically diagnosed in protocol biopsies performed at 3 months or 1 year after transplantation in kidney transplant recipients who have preformed DSAs and are receiving potent immunosuppressive conditioning.

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nrneph.2013.22-pt1

Table 1 Studies in rats showing the involvement of vasopressin and V2Rs in CKDs, albuminuria and hypertension. Bankir, L. et al. (2013) Vasopressin: a novel target for the prevention and retardation of kidney disease? Nat. Rev. Nephrol. doi:10.1038/nrneph.2013.22.

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nrneph.2014.91-pf3

Figure 3 TLRs, NLRs and the NLRP3 inflammasome drive host defence and tissue repair mechanisms by the clearance of pathogens and cell debris and by regulation of repair pathways. Leemans, J. C. et al. (2014) Pattern recognition receptors and the inflammasome in kidney disease

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ncponc1183-pf1

Figure 1 Radiographic changes to melanoma metastases in the brain with administration of CTLA-4 blockade. Hodi FS et al . (2008) CTLA-4 blockade with ipilimumab induces significant clinical benefit in a female with melanoma metastases to the CNS Nat Clin Pract Oncol doi:10.1038/ncponc1183.

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nrneph.2013.110-pf1

Figure 1 Mechanisms by which aldosterone and/or MR activation induce oxidative stress, inflammation, and fibrosis. Brown, N. J. (2013) Contribution of aldosterone to cardiovascular and renal inflammation and fibrosis Nat. Rev. Nephrol. doi:10.1038/nrneph.2013.110.

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Figure 1 World map indicating developing countries as classified by World Bank criteria in color and relating latitude by geographic regions to skin ability to synthesize vitamin D as estimated from information provided in an article by Tavera-Mendoza and White.

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nrneph.2012.196-pf3

Figure 3 Comparison of a mild case and severe case of STEC-HUS treated at the University Hospital in Hamburg–Eppendorf during the German outbreak in 2011. Trachtman, H. et al . (2012) Renal and neurological involvement in typical Shiga toxin-associated HUS

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Figure 1 Whole-body positron emission tomography scan showing a small glucose-avid lesion in the pelvis just superior to the bladder in the region of the left adnexa. Santillan A and Bristow RE (2006) Paraneoplastic cerebellar degeneration in a woman with ovarian cancer

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Figure 1 CT scan of tumor progression showing enlarged right laterocervical lymph nodes (white arrows) and laryngeal tumor (black arrows). Ares C and Allal AS (2005) Long-term complete remission of laryngeal Kaposi's sarcoma after palliative

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Figure 1 The products of two genes are required to reconstitute basic telomerase activity; the RNA component, hTR, which includes the template for synthesis of telomere DNA, and the protein catalytic component, hTERT, which has reverse transcriptase activity.

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ncpgasthep0096-pf1

FIGURE 1 Localization of potential relevant molecular targets in irritable bowel syndrome with the specific classes of agents discussed in this Review. Cremonini F and Talley NJ (2005) Treatments targeting putative mechanisms in irritable bowel syndrome

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Figure 1 Postpartum contrast-enhanced helical chest CT scan showing an enlarged internal mammary lymph node (white arrow). Matthew S Katz et al . (2005) Palpable right breast mass in a pregnant woman . Nat Clin Pract Oncol 2 : 218 – 221 10.1038/ncponc0135.

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ncprheum0173-pf1

Figure 1 Minor salivary gland biopsy, stained with hematoxylin-eosin, from a patient with Sj ö gren's syndrome. Nordmark G et al. (2006) Mechanisms of Disease: primary Sj ö gren's syndrome and the type I interferon system Nat Clin Pract Rheumatol 2: 26 2 – 269 doi:10.1038/ ncprheum0173.

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Figure 1 Combination treatment schema for patients with rectal cancer enrolled in a clinical trial. Willett CG et al . (2007) Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer Nat Clin Pract Oncol 4 : 316 –321 doi:10.1038/ncponc0813.

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Figure 1 Results of cardiac function tests in the phase III trial of lapatinib plus capecitabine for metastatic breast cancer. Permission obtained from Geyer CE et al . (2006) Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med 355: 2733–2743.

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Figure 1 Schematic of oncolytic virotherapy mechanism of action: viral replication, cell killing, virus release and spread within cancer tissue but not normal tissues.

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nrneph.2012.214-pt1

Table 1 Evidence supporting the role of complement dysregulation and the benefit of C5 blockade in aHUS and C3G. Zuber, J. et al. (2012) Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies Nat. Rev. Nephrol. doi:10.1038/nrneph.2012.214.

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nrneph.2012.214-pt2

Table 2 Clinical and genetic characteristics of 24 off-trial patients treated with eculizumab for overt aHUS. Zuber, J. et al. (2012) Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies Nat. Rev. Nephrol. doi:10.1038/nrneph.2012.214.

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ncpneuro0658-pf1

Figure 1 Images of the case patient with an interstitial deletion of 5q22 encompassing the APC (adenomatous polyposis coli) gene, taken at 22 years of age. Heald B et al. (2007) Familial adenomatous polyposis in a patient with unexplained mental retardation

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ncpneph0301-pf1

Figure 1 The principal source of renal dopamine is circulating L -DOPA, which is freely filtered by the glomerulus.

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nrrheum.2014.167 pf1

Figure 1 Infection with JC virus is at first asymptomatic and presumably occurs at an early age by oral route. Calabrese, L. H. et al. (2014) Sorting out the risks in progressive multifocal leukoencephalopathy Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2014.167.

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nrneph.2012.213 pf2

Figure 2 Activation of C3 convertase is involved in both complement-mediated and immune-complex-mediated MPGN. Bomback, A. S. & Appel, G. B. (2012) Pathogenesis of the C3 glomerulopathies and reclassification of MPGN Nat. Rev. Nephrol. doi:10.1038/nrneph.2012.213.

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