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REU Research Program Cancer and Nanoparticle research Dr. J. c. Chiao

By: Michael Lau mlau7@hotmail.com. REU Research Program Cancer and Nanoparticle research Dr. J. c. Chiao. Overview. The traditional cancer treatments tend to be harmful for the body: chemotherapy, surgery, etc.

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REU Research Program Cancer and Nanoparticle research Dr. J. c. Chiao

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  1. By: Michael Lau mlau7@hotmail.com REU Research ProgramCancer and Nanoparticle researchDr. J. c. Chiao

  2. Overview • The traditional cancer treatments tend to be harmful for the body: chemotherapy, surgery, etc. • We are conducting experiments that work with different kinds of nanoparticles in breast cancer cells (MDAMB) and prostate cancer cells (PC-3). • The technique of microfluidics is used so that the control and variable experiments can be carried out with a small amount of resources. UT Arlington REU Program Midterm

  3. The PDMS device UT Arlington REU Program Midterm

  4. Nanoparticle Compatibility • How well did the cells thrive along with the nanoparticles? • Did the cells migrate across the channels? • Do the nanoparticles affect cell growth? UT Arlington REU Program Midterm

  5. Nanoparticle- Gold X100 UT Arlington REU Program Midterm

  6. Nanoparticles - Iron X100 UT Arlington REU Program Midterm

  7. Nanoparticles - Nickel X100 UT Arlington REU Program Midterm

  8. Nanoparticles - Comparison UT Arlington REU Program Midterm

  9. Example of Cell Migration UT Arlington REU Program Midterm

  10. Conclusion from Experiment • The cytotoxicity of gold and iron are at reasonable levels so that the cells will not lyse and die. (Good for experimentation) • However, the nickel NPs are cytotoxic, which makes the cells curl up and lyse. (Bad for experimentation) UT Arlington REU Program Midterm

  11. Possible Future Research • Certain cancer cells metastasize in specific areas. We would test to see how different tissues act as chemo-attractants to different cancer types (stemmed into another experiment). • Use magnets to see if magnetic fields affect migration across the channels. • Coating the nanoparticles with polymers so that drug molecule attachment could be possible (PEG). UT Arlington REU Program Midterm

  12. Side Project: Bacteria • Contamination in the experiment leads to a novel experiment. UT Arlington REU Program Midterm

  13. “Gating” UT Arlington REU Program Midterm

  14. “Gating” Process UT Arlington REU Program Midterm

  15. Applications • Possible creation of a nano-filter for bacteria. • A prevention of fluid dynamics or “backflow” in microfluidics. • Bacteria + nanoparticles results in…? UT Arlington REU Program Midterm

  16. Back Flow UT Arlington REU Program Midterm

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