1 / 37

Amyloidosis

AMYLOIDOSIS . Amyloid is a pathologic proteinaceous substance, deposited between cells in various tissues and organs of the body in a wide variety of clinical settings.Amyloidosis is not a single disease; rather it is a group of diseases having in common the deposition of similar-appearing proteins

zach
Download Presentation

Amyloidosis

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

    1. Amyloidosis Dr Hisham Alkhalidi

    2. AMYLOIDOSIS Amyloid is a pathologic proteinaceous substance, deposited between cells in various tissues and organs of the body in a wide variety of clinical settings. Amyloidosis is not a single disease; rather it is a group of diseases having in common the deposition of similar-appearing proteins.

    3. AMYLOIDOSIS It is a condition associated with a number of inherited and inflammatory disorders in which extracellular deposits of fibrillar proteins are responsible for tissue damage and functional compromise. These abnormal fibrils are produced by the aggregation of misfolded proteins (which are soluble in their normal folded configuration).

    4. The fibrillar deposits bind a wide variety of: Proteoglycans Glycosaminoglycans Plasma proteins, notably serum amyloid P component (SAP) - Approximately 95% of the amyloid material consists of fibril proteins The remaining 5% is P component and other glycoproteins. Chemical Nature of Amyloid

More Related