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Definitions (according to different sources). Amyloidosis is a systemic disease, characterized by deposition of specific fibrillar protein, localizing perireticularly or around the collagen fibers, that leads to affected organs impairment.Amyloidosis is a disorder of protein metabolism, which may be either acquired or hereditary, characterized by extracellular deposition of abnormal protein fibrils.Amyloidosis is a clinical disorder caused by extracellular deposition of insoluble abnormal fibr9440

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