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Genomic Information Impact on Behavior: Risks vs. Benefits

Explore the influence of personal genomic data on behavior, addressing benefits, risks, regulations, and related medical factors. Anecdotes and studies provide insights into behavior changes, anxiety levels, and societal perceptions. Analyze the importance of individual genetic testing and its impact on health choices.

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Genomic Information Impact on Behavior: Risks vs. Benefits

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  1. Does knowing personal genomic information change behavior? Nate Cira Gene 210 6/5/2012

  2. Importance • Are there benefits to testing? • Are there risks from testing? • Should people be tested? • Should tests be regulated? • Relation to other medical risk factors?

  3. Class Related Anecdotes • Robin Starr • Breast cancer • Rosalind Chuang • Denial and Insistence • Steve Quake • Statins

  4. Single Alleles • 35 article review • Including colorectal cancer, Alzheimer’s, breast and ovarian cancer • Short term distress and anxiety • Slightly increased screening • Perceived risk increases then returns to noncarrier by a year Heskaet al. Genetics in Medicine. 2008

  5. Scripps Study Navigenics test 6 month follow-up ~2000 surveyed Large dropout Blosset al. NEJM 2011

  6. Keyan’s survey • Initial 210 class • Found better learning in those genotyped • Submitted for publication

  7. This year’s survey: Population • Population • 19 responses • 16 were genotyped/3 were not • 9 female/10 male

  8. Behavior: Exercise

  9. Behavior: Diet

  10. Behavior

  11. Outlook: Non-health

  12. Outlook: Health

  13. Outlook: Anxiety

  14. Sharing

  15. Anticipation

  16. Engagement

  17. Pressure

  18. Genotyping

  19. Conclusions • Sample size • Self-reporting • Short term • Links between gender and anxiety • Representative? • Other medical risk factors?

  20. Questions ?

  21. Thoughts • Bias against improved health and exercise • Might in future insist on extra testing • Small sample size • Self reporting • All people changing anxiety were female

  22. 'Does knowing personal genomic information change behavior?' - Why is this question important - Studies on single alleles (BRCA, ect.) - Scripps study and associated literature - Keyan's survey - Anecdotes from Robin, and Steve Quake - Results from my survey - Summary and concluding remarks

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