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Does knowing personal genomic information change behavior?

Does knowing personal genomic information change behavior?. Nate Cira Gene 210 6/5/2012. Importance. Are there benefits to testing? Are there risks from testing? Should people be tested? Should tests be regulated? Relation to other medical risk factors?. Class Related Anecdotes.

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Does knowing personal genomic information change behavior?

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  1. Does knowing personal genomic information change behavior? Nate Cira Gene 210 6/5/2012

  2. Importance • Are there benefits to testing? • Are there risks from testing? • Should people be tested? • Should tests be regulated? • Relation to other medical risk factors?

  3. Class Related Anecdotes • Robin Starr • Breast cancer • Rosalind Chuang • Denial and Insistence • Steve Quake • Statins

  4. Single Alleles • 35 article review • Including colorectal cancer, Alzheimer’s, breast and ovarian cancer • Short term distress and anxiety • Slightly increased screening • Perceived risk increases then returns to noncarrier by a year Heskaet al. Genetics in Medicine. 2008

  5. Scripps Study Navigenics test 6 month follow-up ~2000 surveyed Large dropout Blosset al. NEJM 2011

  6. Keyan’s survey • Initial 210 class • Found better learning in those genotyped • Submitted for publication

  7. This year’s survey: Population • Population • 19 responses • 16 were genotyped/3 were not • 9 female/10 male

  8. Behavior: Exercise

  9. Behavior: Diet

  10. Behavior

  11. Outlook: Non-health

  12. Outlook: Health

  13. Outlook: Anxiety

  14. Sharing

  15. Anticipation

  16. Engagement

  17. Pressure

  18. Genotyping

  19. Conclusions • Sample size • Self-reporting • Short term • Links between gender and anxiety • Representative? • Other medical risk factors?

  20. Questions ?

  21. Thoughts • Bias against improved health and exercise • Might in future insist on extra testing • Small sample size • Self reporting • All people changing anxiety were female

  22. 'Does knowing personal genomic information change behavior?' - Why is this question important - Studies on single alleles (BRCA, ect.) - Scripps study and associated literature - Keyan's survey - Anecdotes from Robin, and Steve Quake - Results from my survey - Summary and concluding remarks

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