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Course outline. Bioseparations engineeringIntroduction to membranes and membrane processesBioseparation using ultrafiltrationBioseparation using adsorptive membranesSpecial topics. . Course material. Handouts (for sections 1 and 5)Suggested Text: Protein Bioseparation Using Ultrafiltration Theory Applications and new Developments, R. Ghosh, Imperial College Press (2003) ISBN: 1860943179 (for sections 1, 2 and 3)Review papers (for section 4).
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1. ChE 742Membrane Based Bioseparations Instructor:
Dr. Raja Ghosh
JHE-250A
Ext. 27415
Email: rghosh@mcmaster.ca
9 lectures + 2-3 tutorials
Mondays 1:30-3:30 JHE 265
2. Course outline Bioseparations engineering
Introduction to membranes and membrane processes
Bioseparation using ultrafiltration
Bioseparation using adsorptive membranes
Special topics
3. Assessment method One written examination at the end of the course (60% marks)
80% numerical problems + 20% theory questions
Open book/open notes exam
Any type of calculator can be used in the exam
Term paper: (20% marks)
Presentation based on term paper: (5% marks)
Assignments 3@5%: 15%
4. Bioseparations engineering1 lecture Introduction
Biological products
Bioseparation requirements
Economic importance of bioseparations engineering
Strategies for bioseparation
Bioseparation methods
5. Introduction to membranes and membrane processes2 lectures Membrane material and chemistry
Membrane structure and morphology
Membrane characterization
Driving force in membrane separation processes
Membrane processes that separate primarily based on size
Membrane processes that separate based on principles other than size
Membrane devices
Modes of operation.
6. Bioseparation using ultrafiltration4 lectures Introduction to ultrafiltration; applications; advantages over competing technologies; permeate flux and membrane transport models; membrane fouling; critical flux concept; concentration polarization; enhancement of permeate flux; transport of proteins and other biological macromolecules through membranes; membrane rejection and sieving coefficients; selectivity of separation; protein concentration processes; protein clarification processes; protein desalting and diafiltration; protein fractionation processes; modes of operation; challenges and new developments.
7. Bioseparation using adsorptive membranes1 lecture Introduction
Advantages of using adsorptive membranes
Membrane material
Separation chemistries
Devices
Applications
Challenges and new developments.