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ChE 742 Membrane Based Bioseparations

Course outline. Bioseparations engineeringIntroduction to membranes and membrane processesBioseparation using ultrafiltrationBioseparation using adsorptive membranesSpecial topics. . Course material. Handouts (for sections 1 and 5)Suggested Text: Protein Bioseparation Using Ultrafiltration Theory Applications and new Developments, R. Ghosh, Imperial College Press (2003) ISBN: 1860943179 (for sections 1, 2 and 3)Review papers (for section 4).

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ChE 742 Membrane Based Bioseparations

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    1. ChE 742 Membrane Based Bioseparations Instructor: Dr. Raja Ghosh JHE-250A Ext. 27415 Email: rghosh@mcmaster.ca 9 lectures + 2-3 tutorials Mondays 1:30-3:30 JHE 265

    2. Course outline Bioseparations engineering Introduction to membranes and membrane processes Bioseparation using ultrafiltration Bioseparation using adsorptive membranes Special topics

    3. Assessment method One written examination at the end of the course (60% marks) 80% numerical problems + 20% theory questions Open book/open notes exam Any type of calculator can be used in the exam Term paper: (20% marks) Presentation based on term paper: (5% marks) Assignments 3@5%: 15%

    4. Bioseparations engineering 1 lecture Introduction Biological products Bioseparation requirements Economic importance of bioseparations engineering Strategies for bioseparation Bioseparation methods

    5. Introduction to membranes and membrane processes 2 lectures Membrane material and chemistry Membrane structure and morphology Membrane characterization Driving force in membrane separation processes Membrane processes that separate primarily based on size Membrane processes that separate based on principles other than size Membrane devices Modes of operation.

    6. Bioseparation using ultrafiltration 4 lectures Introduction to ultrafiltration; applications; advantages over competing technologies; permeate flux and membrane transport models; membrane fouling; critical flux concept; concentration polarization; enhancement of permeate flux; transport of proteins and other biological macromolecules through membranes; membrane rejection and sieving coefficients; selectivity of separation; protein concentration processes; protein clarification processes; protein desalting and diafiltration; protein fractionation processes; modes of operation; challenges and new developments.

    7. Bioseparation using adsorptive membranes 1 lecture Introduction Advantages of using adsorptive membranes Membrane material Separation chemistries Devices Applications Challenges and new developments.

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