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Body composition assessment in chronic kidney disease

Body composition assessment in chronic kidney disease. Jamie Macdonald. Five levels of body composition. Whole body Tissue Cellular Molecular Atomic. Why measure body composition in CKD?.

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Body composition assessment in chronic kidney disease

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  1. Body composition assessment in chronic kidney disease Jamie Macdonald

  2. Five levels of body composition • Whole body • Tissue • Cellular • Molecular • Atomic

  3. Why measure body composition in CKD? • Muscle wasting is linked with morbidity (Ikizler et al., 1999) and mortality (Kato et al., 2003) • Obesity is also associated with outcome (Kalantar-Zadeh et al., 2005)

  4. Effects of body composition on functional capacity Data are Pearson’s r correlation coefficients. *, p < 0.001. Macdonald et al., 2004

  5. Body composition in CKD Macdonald et al., 2004

  6. Whole body level • Something is better than nothing! • Weight • BMI • Interpret results with caution! • Muscle or fat? (Beddhu et al., 2003) • Reverse epidemiology? (Kalantar-Zadeh et al., 2005) • Scales must be calibrated frequently • Remove shoes, wear minimal clothing I don’t believe it!!!

  7. Traditional techniques • Blood biochemistry • Serum pre/albumin • CRP • SGA • Anthropometry • Skin folds • Circumferences • Creatinine kinetics

  8. DXA

  9. Bioelectrical impedance Macdonald et al., in submission

  10. Rikli & Jessie Jones, Human Kinetics, 2000 Monitoring progress: functional capacity

  11. Future techniques • Near infra-red spectroscopy (Kalantar-Zadeh et al., 1999) • Bioelectrical impedance • Spectroscopy (Kaysen et al., 2005) • Segmental spectroscopy (Zhu et al., 2006) • Raw electrical data (KDOQI) • Ultrasound(Mercer et al., 2005)

  12. Thank you

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