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Key Insights on Tandem Mass Spectrometry for Newborn Screening — Session II Overview

This session summary by Dr. John E. Sherwin from the California Department of Health highlights crucial aspects of tandem mass spectrometry (TMS) in newborn screening. It emphasizes the importance of clear reporting, establishing reference ranges from appropriate cohorts, and the significance of analyte ratios such as Phe/Tyr and C8/C10. Effective communication is underscored as essential for quality assurance. The session covers the necessity of detailed documentation, plans for internal and external quality control, and the need for educating users on report interpretation.

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Key Insights on Tandem Mass Spectrometry for Newborn Screening — Session II Overview

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  1. Tandem Mass Spectrometry in Newborn Screening Summary of Session II John E. Sherwin, Ph.D. California Department of Health

  2. Reporting is Communication • Report should include a reference range • Range should be from an appropriate cohort • As appropriate ratios of analytes should be used e.g. Phe/Tyr or C8/C10 • Study age, weight, prematurity for effect on the data • Good Communication is an essential

  3. Quality Assurance • Have a plan and use it • Both internal and external QC are essential • Internal QC will help with Accuracy/Precision • External QC will help relate your program to others

  4. Other Considerations • Quality Control & Quality Assurance Plans • Corrective Action is a crucial part of the plan • Document, Document, Document

  5. Summary • Develop appropriate Reports • Educate users on interpretation of your Reports • Establish a Quality Assurance Plan and adhere to it • Communicate Well with Community

  6. Tandem Mass Spectrometry in Newborn Screening - Resources • CDC/APHL NBS QA Program • CLIA QA Requirements-Subpart K • Association of Public Health Laboratories • National Newborn Screening & Genetics Resource Center • Training – Laboratory & Follow up • Listserv’s – general NBS, also MS Users Group • Dr. Brad Therrell, 512-454-6419, therrell@uthscsa.edu

  7. Questions?

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