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Comprehensive Guide to Tandem Mass Spectrometry in Newborn Screening

This session summary covers essential aspects of tandem mass spectrometry for newborn screening, including instrument performance, method validation, quality assurance, routine operations, and available resources. Key topics such as training, communication, and data handling are emphasized to ensure accurate and reliable screening results.

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Comprehensive Guide to Tandem Mass Spectrometry in Newborn Screening

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  1. Tandem Mass Spectrometry in Newborn Screening Summary of Session I Bill Becker, DO MPH Ohio Department of Health

  2. Getting Started • Planning – space, equipment, training • Importance of a clinical perspective • State’s Advisory Committee/Council • Educational materials • Parents & providers • Good Communication

  3. Instrument Performance • Training, Training, & More Training • Understand instrument performance • “soup to nuts” • Optimize variables • Understand the things that impact “run time” • Internal Standards

  4. Method Validation • Linearity • Precision – inter and intra-assay • Accuracy/Precision • Target CV’s suggested

  5. Other Considerations • Interferences & Sources of Contamination • Establishing Analyte Cutoffs • Quality Control & Quality Assurance Plans • Document, Document, Document

  6. Routine Operations • Maintenance • Tuning Solution • Reagent & I.S. Preparation • Preparation of Samples & Controls • Analysis & Data Handling

  7. Summary • Plan Ahead • Train & Educate • Rigorous Method Validation • Establish a Quality Assurance Plan • Communicate Well with Community

  8. Tandem Mass Spectrometry in Newborn Screening - Resources • CDC NBS QA Program • Association of Public Health Laboratories • National Newborn Screening & Genetics Resource Center • Training – Laboratory & Follow up • Listserv’s – general NBS, also MS Users Group • Dr Brad Therrell, 512-454-6419, therrell@uthscsa.edu

  9. Questions?

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