Second Messengers and Signal Transduction. Tim Bloom, Ph.D. 104A Hall of Science 893-1712. Overview. Signal transduction- a concept Second messengers Characteristics Examples Benefits . Signal Transduction. Intra cellular communication Detection of extracellular event
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Tim Bloom, Ph.D.
104A Hall of Science
G protein-coupled receptorSignaling Examples
-cAMP Signaling Path
Agonist for internal calcium channel
Multiple effects through Ca++-binding proteins
Targets PKC (a kinase)
PKC requires Ca++ and DAG
Mimicked by phorbol esters (tumorogenic)Phospholipase C as Effector
IP3 & DAG