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Understanding MHC II Alleles Heterozygosity & T-cell Lineage in Immunology

This text delves into the genetic complexity of MHC II alleles and T-cell lineage rearrangement processes in immunology. It discusses conflicting information regarding HLA heterozygous expression and provides insights into the specific rearrangement order and outcomes in T-cell development.

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Understanding MHC II Alleles Heterozygosity & T-cell Lineage in Immunology

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  1. Heterozygous for all alleles in MHC II DRA-m or p DRB1-m DRA-m or p DRB1-p DRA-m or p DRB3,4, or 5 m DRA-m or p DRB3,4, or 5 p DQA-m DQB-m DQA-p DQB-p DQA-m DQB-p DQA-p DQB-m DPA-m DPB-m DPA-p DPB-p DPA-m DPB-p DPA-p DPB-m Makes 12 (and some 16) “HLA heterozygous individuals can express up to six class I and eight class II” - quote in Ch 3 conflicts with Figure A3.9 and my calculations

  2. T cell lineage (Chapter 5) Rearrangement order Outcome   and  are rearranged ---> cell   and  are rearranged ---> cell   and  are rearranged ---> cell   and  are rearranged ---> cell   and  are rearranged ---> cell   rearranged ( rearranged&excised) ---> cell   and  are rearranged ---> cell   and  are rearranged ---> cell   and  are rearranged ---> cell   and  are rearranged ---> cell   rearranged ( rearranged&excised) ---> cell

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